Reactome | SOD3 [extracellular region]

SOD3 [extracellular region]

Stable Identifier

R-HSA-3299690

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Extracellular superoxide dismutase [Cu-Zn], SODE_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q9Y2W7 KCNIP3

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        NFE2L2 regulating anti-oxidant/detoxification enzymes (Homo sapiens)
        
        NFE2L2 dependent SOD3 expression (Homo sapiens)
        
        SOD3 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P08294 SOD3

Gene Names

SOD3

Chain

signal peptide:1-18, chain:19-240

Reference Genes

BioGPS Gene:6649 SOD3

COSMIC (genes):SOD3 SOD3

CTD Gene:6649 SOD3

dbSNP Gene:6649 SOD3

ENSEMBL:ENSG00000109610 SOD3

HGNC:11181 SOD3

KEGG:hsa:6649 SOD3

Monarch:6649 SOD3

NCBI Gene:6649 SOD3

OMIM:185490 SOD3

UCSC:P08294 SOD3

Reference Transcript

RefSeq:NM_003102.2 SOD3

Other Identifiers

11718428_x_at

11756726_a_at

16965519

205236_PM_x_at

205236_x_at

2721637

2721638

2721639

2721640

2721641

2721642

2721643

6649

692_s_at

8094372

A_23_P254741

GE79237

GO:0001666

GO:0003013

GO:0003824

GO:0004784

GO:0005507

GO:0005515

GO:0005576

GO:0005615

GO:0005794

GO:0005796

GO:0006801

GO:0006979

GO:0008201

GO:0016209

GO:0016491

GO:0019430

GO:0030312

GO:0031012

GO:0043226

GO:0046688

GO:0046872

GO:0060090

GO:0062023

GO:0070062

GO:0097746

GO:0098754

HMNXSV003013861

ILMN_1690034

J02947_s_at

PH_hs_0000326

TC04000173.hg

g4507150_3p_at

Participates

as an output of

NFE2L2 dependent SOD3 expression (Homo sapiens)

as a member of

SOD3 (cleaved and uncleaved) [extracellular region] (Homo sapiens)

Other forms of this molecule

SOD3 (19-227) [extracellular region]

SOD3 [Golgi lumen]

Inferred To

Homologues of SOD3 [extracellular region] (Dictyostelium discoideum)

sod3 [extracellular region] (Xenopus tropicalis)

SOD3 [extracellular region] (Bos taurus)

SOD3 [extracellular region] (Canis familiaris)

SOD3 [extracellular region] (Dictyostelium discoideum)

SOD3 [extracellular region] (Gallus gallus)

SOD3 [extracellular region] (Mus musculus)

SOD3 [extracellular region] (Rattus norvegicus)

SOD3 [extracellular region] (Saccharomyces cerevisiae)

SOD3 [extracellular region] (Schizosaccharomyces pombe)

SOD3 [extracellular region] (Sus scrofa)

sod3a [extracellular region] (Danio rerio)

Cross References

ENSEMBL

ENST00000382120, ENSP00000371554

OpenTargets

ENSG00000109610

IntEnz

1.15.1.1

HPA

ENSG00000109610-SOD3

ZINC - Substances

SODE_HUMAN

ZINC target

P08294

PRO

P08294

Pharos - Targets

P08294

HMDB Protein

HMDBP03151

PDB

2JLP

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
IntAct:EBI-23653849 CCSB ORF ID			0.556	3
UniProt:Q96EQ0 SGTB			0.556	3
UniProt:Q9NZI2-2 Q9NZI22-1			0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:Q9Y2W7 KCNIP3	2	KCNIP3 [plasma membrane] (R-HSA-5577044) KCNIP3 [nucleoplasm] (R-HSA-9640052)	0.556	6
UniProt:Q12797-6 ASPH			0.556	3