Reactome | GSTK1 dimer transfers GS from GSH to CDNB

GSTK1 dimer transfers GS from GSH to CDNB

Stable Identifier

R-HSA-3301943

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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GSTK1 dimer transfers GS from GSH to CDNB

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Glutathione S-transferase Kappa isozyme (GSTK1) is widely expressed in human tissues and exists as a dimer in mitochondria and peroxisomes. It has high activity towards aryl halides such as the model substrate 1-chloro-2,4-dinitrobenzene (CDNB) to which it can conjugate with glutathionate (GS-) from glutathione (GSH) (Morel et al. 2004). Mouse, rat and human possess only one GST Kappa isozyme.

Literature References

PubMed ID	Title	Journal	Year
14742434	Gene and protein characterization of the human glutathione S-transferase kappa and evidence for a peroxisomal localization Petit, E, Coles, B, Theret, N, Rauch, C, Piton, A, Morel, F, Guillouzo, A	J. Biol. Chem.	2004