p-S423,S425-SMAD3 D258N [cytosol]

Stable Identifier
R-HSA-3315470
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
p-Ser423,Ser425-SMAD3 Asp258Asn
p-S423,S425-SMAD3 D258N [cytosol] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
23139211 SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer

Mouradov, D, Jorissen, RN, Jones, IT, Tsui, C, Palmieri, M, Sieber, OM, Ward, RL, Fleming, NI, Mariadason, JM, Sakthianandeswaren, A, Lipton, L, Moore, J, Ruszkiewicz, AR, Busam, D, Christie, M, McLaughlin, S, Gibbs, P, Zhu, HJ, Strausberg, RL, Day, F, Li, S, Burgess, AW, Hawkins, NJ, Desai, J, Zhao, Q

Cancer Res. 2013
External Reference Information
External Reference
Gene Names
SMAD3, MADH3
Chain
initiator methionine:, chain:2-425
Other Identifiers
11718265_a_at
11718266_s_at
11726549_a_at
11751185_a_at
11754091_s_at
1433_g_at
1454_at
1950_s_at
205396_PM_at
205396_at
205397_PM_x_at
205397_x_at
205398_PM_s_at
205398_s_at
218284_PM_at
218284_at
3598960
3598961
3598977
3598984
3598992
3598993
3598994
3598995
3598997
3598999
3599014
3599016
3599023
3599028
3599029
3599030
3599031
3599032
3599033
3599034
3599035
3599036
3599037
3599038
3599039
3599040
3599041
3599042
38944_at
4088
44841_at
44986_s_at
51059_at
58763_at
65983_at
7984364
A_14_P107358
A_23_P48936
GE56446
GE79350
GO:0000122
GO:0000165
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001217
GO:0001222
GO:0001223
GO:0001228
GO:0001501
GO:0001649
GO:0001657
GO:0001666
GO:0001701
GO:0001707
GO:0001756
GO:0001889
GO:0001947
GO:0002076
GO:0002376
GO:0002520
GO:0003012
GO:0003013
GO:0003677
GO:0003682
GO:0003690
GO:0003700
GO:0005160
GO:0005515
GO:0005518
GO:0005634
GO:0005635
GO:0005637
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006357
GO:0006886
GO:0006913
GO:0006919
GO:0006954
GO:0006955
GO:0007010
GO:0007155
GO:0007179
GO:0007254
GO:0007369
GO:0007492
GO:0008013
GO:0008270
GO:0008285
GO:0009653
GO:0009880
GO:0010628
GO:0010629
GO:0010718
GO:0012501
GO:0016202
GO:0016922
GO:0017015
GO:0017151
GO:0019899
GO:0019901
GO:0019902
GO:0023019
GO:0023052
GO:0030154
GO:0030163
GO:0030198
GO:0030308
GO:0030325
GO:0030335
GO:0030501
GO:0030878
GO:0031047
GO:0031053
GO:0031490
GO:0031625
GO:0031962
GO:0032332
GO:0032731
GO:0032810
GO:0032909
GO:0032916
GO:0032924
GO:0033689
GO:0034330
GO:0035259
GO:0038092
GO:0042060
GO:0042110
GO:0042177
GO:0042307
GO:0042802
GO:0042803
GO:0043066
GO:0043130
GO:0043226
GO:0043235
GO:0043425
GO:0043565
GO:0045216
GO:0045429
GO:0045599
GO:0045668
GO:0045893
GO:0045944
GO:0046872
GO:0048340
GO:0048589
GO:0048617
GO:0048701
GO:0048856
GO:0048870
GO:0050678
GO:0050728
GO:0050776
GO:0050821
GO:0050927
GO:0051091
GO:0051481
GO:0051496
GO:0051894
GO:0060039
GO:0060290
GO:0060395
GO:0061045
GO:0061629
GO:0061767
GO:0070306
GO:0070410
GO:0070411
GO:0070412
GO:0071141
GO:0071144
GO:0071333
GO:0071560
GO:0090263
GO:0097191
GO:0098586
GO:0140110
GO:0140297
GO:1901203
GO:1902893
GO:1902894
GO:1902895
GO:1903243
GO:1990776
GO:1990841
HMNXSV003022522
Hs.211578.0.S3_3p_at
ILMN_1682738
PH_hs_0032513
PH_hs_0039929
TC15000622.hg
TC15002251.hg
U68019_at
g1673576_3p_s_at
g5174512_3p_s_at
g7661691_3p_at
Participates
Other forms of this molecule
Modified Residues
Name
L-aspartic acid 258 replaced with L-asparagine
Coordinate
258
PsiMod
A protein modification that effectively removes or replaces an L-aspartic acid.
A protein modification that effectively converts a source amino acid residue to an L-asparagine.
Name
O-phospho-L-serine at 423
Coordinate
423
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 425
Coordinate
425
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
large intestine cancer DOID:5672 malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
Interactors (71)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q13485 SMAD4  20 0.98 35
 UniProt:P12755 SKI  1 0.837 11
 UniProt:O95405 ZFYVE9      0.821 7
 UniProt:Q9H2G9 BLZF1  1 0.805 9
 UniProt:Q9H0M0 WWP1  1 0.805 9
 UniProt:Q9HAU4 SMURF2  2 0.799 8
 UniProt:O00308 WWP2  1 0.779 7
 UniProt:P50222 MEOX2      0.718 6
 UniProt:Q13573 SNW1  1 0.69 5
 UniProt:Q15796 SMAD2  20 0.678 3
 UniProt:O75593 FOXH1  1 0.675 4
 UniProt:Q9Y2U8 LEMD3  4 0.669 4
 UniProt:O43524 FOXO3  11 0.667 5
 UniProt:Q08117 TLE5  1 0.666 4
 UniProt:Q8N5R6 CCD33      0.666 4
 UniProt:P84022 SMAD3  20 0.656 3
 UniProt:Q64729  3 0.576 6
 UniProt:Q9BZ29 DOCK9  1 0.576 3
 UniProt:Q93009 USP7  2 0.573 2
 UniProt:P10070 GLI2  11 0.558 4
 UniProt:P46934-3 NEDD4      0.556 3
 UniProt:P17612 PRKACA  4 0.556 3
 UniProt:Q06481-5 APLP2      0.556 3
 UniProt:P48730-2 CSNK1D      0.556 3
 UniProt:P29466-3 CASP1      0.556 3
 UniProt:Q86YD7 F90A1      0.556 3
 UniProt:Q8N684-3 CPSF7      0.556 3
 UniProt:P0C264 SBK3      0.556 3
 UniProt:Q8IXK0-5 PHC2      0.556 3
 UniProt:E9PSE9 E9PSE9      0.556 3
 UniProt:P27986-2 PIK3R1      0.556 3
 IntAct:EBI-16439879 CCSB ORF ID      0.556 3
 UniProt:Q08117-2 TLE5      0.556 3
 UniProt:O43186 CRX      0.556 3
 UniProt:Q15583 TGIF1  1 0.556 3
 UniProt:Q96PZ7 CSMD1      0.556 3
 UniProt:Q8WXH2 JPH3      0.556 3
 UniProt:Q8WW24 TEKT4      0.556 3
 UniProt:Q8N684 CPSF7  2 0.556 3
 UniProt:P05067 APP  20 0.556 3
 UniProt:Q9UQM7 CAMK2A  6 0.556 3
 UniProt:Q8IXK0 PHC2  1 0.556 3
 IntAct:EBI-10171584 80125      0.556 3
 UniProt:Q6NX45 ZNF774  1 0.556 3
 UniProt:P20618 PSMB1  7 0.556 3
 UniProt:P15822 ZEP1      0.553 2
 UniProt:P06428 VE6      0.547 2
 UniProt:O15397 IPO8  2 0.544 2
 UniProt:Q99836 MYD88  8 0.543 3
 UniProt:Q13501 SQSTM1  7 0.543 3
 UniProt:Q9GZZ8 LACRT      0.527 2
 UniProt:P51141 Dvl1  4 0.527 2
 UniProt:Q9NYA4 MTMR4  2 0.524 2
 UniProt:P98082 DAB2  3 0.524 3
 UniProt:Q99814 EPAS1 (HIF2A)  5 0.519 2
 UniProt:Q9BZL4 PP12C      0.508 2
 UniProt:Q9H2X0 CHRD      0.508 2
 UniProt:Q96EP0 RNF31  1 0.508 2
 UniProt:Q9Y3Q8 T22D4      0.508 2
 UniProt:Q5D1E8 ZC3H12A  1 0.508 2
 UniProt:Q16822 PCK2  1 0.508 2
 UniProt:Q9BYW2 SETD2  1 0.508 2
 UniProt:Q01543 FLI1  1 0.508 3
 UniProt:P17844 DDX5  4 0.499 2
 UniProt:Q05066 SRY  1 0.499 3
 UniProt:P06930 VE6      0.488 2
 UniProt:P36801 VE6      0.488 2
 UniProt:P23142 FBLN1  1 0.488 2
 UniProt:Q93062-3 RBPMS      0.488 2
 UniProt:Q16665 HIF1A  7 0.463 6
 UniProt:Q9NZH6 IL37  6 0.463 2
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