Reactome | BRPF1 [nucleoplasm]

BRPF1 [nucleoplasm]

Stable Identifier

R-HSA-3318466

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Peregrin, BRPF1_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Acetylation (Homo sapiens)
        
        AKT phosphorylates KAT6A (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        BRPF1, (BRPF2, 3) [nucleoplasm] (Homo sapiens)
        
        BRPF1 [nucleoplasm] (Homo sapiens)
        
        p-T369-KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        BRPF1, (BRPF2, 3) [nucleoplasm] (Homo sapiens)
        
        BRPF1 [nucleoplasm] (Homo sapiens)
        
        KAT6A acetylates TP53 (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        BRPF1, (BRPF2, 3) [nucleoplasm] (Homo sapiens)
        
        BRPF1 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        BRPF1, (BRPF2, 3) [nucleoplasm] (Homo sapiens)
        
        BRPF1 [nucleoplasm] (Homo sapiens)
        
        KAT6A and PML bind TP53 (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        BRPF1, (BRPF2, 3) [nucleoplasm] (Homo sapiens)
        
        BRPF1 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        BRPF1, (BRPF2, 3) [nucleoplasm] (Homo sapiens)
        
        BRPF1 [nucleoplasm] (Homo sapiens)
        
        MTA2-NuRD complex deacetylates TP53 (Homo sapiens)
        
        BRD7:Ac-K382,p-S15,S20-TP53:EP300, KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        BRPF1, (BRPF2, 3) [nucleoplasm] (Homo sapiens)
        
        BRPF1 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,p-S15,S20-TP53, BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        BRPF1, (BRPF2, 3) [nucleoplasm] (Homo sapiens)
        
        BRPF1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P55201 BRPF1

Gene Names

BRPF1, BR140

Chain

chain:1-1214

Reference Genes

BioGPS Gene:7862 BRPF1

COSMIC (genes):BRPF1 BRPF1

CTD Gene:7862 BRPF1

dbSNP Gene:7862 BRPF1

ENSEMBL:ENSG00000156983 BRPF1

HGNC:14255 BRPF1

KEGG:hsa:7862 BRPF1

Monarch:7862 BRPF1

NCBI Gene:7862 BRPF1

OMIM:602410 BRPF1

UCSC:P55201 BRPF1

Reference Transcript

Other Identifiers

11722643_a_at

16937309

204481_PM_at

204481_at

2609871

2609872

2609873

2609874

2609875

2609876

2609877

2609878

2609879

2609881

2609883

2609884

2609885

2609886

2609887

2609888

2609889

2609890

2609892

2609893

2609894

2609895

2609896

2609898

2609899

2609901

2609903

2609905

2609906

2609907

41103_at

7862

8077595

A_14_P116257

A_14_P200081

A_23_P250948

GE58139

GO:0000123

GO:0003677

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005886

GO:0006325

GO:0006338

GO:0006355

GO:0006357

GO:0010698

GO:0016740

GO:0043226

GO:0043995

GO:0043996

GO:0043997

GO:0045893

GO:0046872

GO:0050793

GO:0070776

GO:0098772

GO:0140096

GO:1903706

HMNXSV003019931

HMNXSV003031388

ILMN_1669308

ILMN_2365549

M91585_at

PH_hs_0030861

TC03000041.hg

g4757865_3p_at

Participates

as a member of

BRPF1, (BRPF2, 3) [nucleoplasm] (Homo sapiens)

Inferred To

lin-49 [nucleoplasm] (Caenorhabditis elegans)

Brpf1 [nucleoplasm] (Mus musculus)

Brpf1 [nucleoplasm] (Rattus norvegicus)

nto1 [nucleoplasm] (Schizosaccharomyces pombe)

BRPF1 [nucleoplasm] (Bos taurus)

BRPF1 [nucleoplasm] (Canis familiaris)

BRPF1 [nucleoplasm] (Dictyostelium discoideum)

BRPF1 [nucleoplasm] (Drosophila melanogaster)

BRPF1 [nucleoplasm] (Gallus gallus)

BRPF1 [nucleoplasm] (Sus scrofa)

brpf1 [nucleoplasm] (Danio rerio)

brpf1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_004625.2, NP_001003694.1, NP_001305978.1, NP_001305979.1

Guide to Pharmacology - Targets

2730

OpenTargets

ENSG00000156983

ENSEMBL

ENSP00000402485, ENSP00000508256, ENST00000383829, ENST00000684199, ENST00000684333, ENST00000433861, ENSP00000507469, ENSP00000506921, ENST00000683743, ENSP00000373340

HPA

ENSG00000156983-BRPF1

ZINC - Substances

BRPF1_HUMAN

ZINC target

P55201

PRO

P55201

Pharos - Targets

P55201

ZINC - Predictions - Purchasable

BRPF1_HUMAN

PDB

5C87, 5E3G, 5EPS, 2RS9, 5OV8, 6U04, 5E3D, 5O4S, 5O4T, 5ETD, 2X4Y, 5OWB, 5FG4, 2X4X, 3L42, 5MWH, 5EWH, 5MWG, 5O5H, 5O5F, 4QYL, 5O5A, 5D7X, 5MWZ, 5ERC, 5G4R, 3MO8, 5FFY, 2X35, 5DYA, 5EWD, 5C89, 5C85, 5EPR, 5C7N, 5O55, 5EQ1, 5EV9, 5EVA, 5T4U, 5T4V, 5EWV, 5EWW, 5C6S, 5OWA, 2X4W, 5FG5, 5OWE, 5EM3, 7C4I, 5DY7, 4UYE, 5DYC, 4LC2, 4QYD, 5ETB, 5G4S, 5MYG, 5FFW, 2D9E, 5FFV, 6EKQ, 5EWC

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62805 H4C1	17	HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) HIST1H4A [extracellular region] (R-HSA-977569) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531)	0.558	8