Reactome | MCRS1 [nucleoplasm]

MCRS1 [nucleoplasm]

Stable Identifier

R-HSA-3321849

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Microspherule protein 1, MCRS1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O94972 TRIM37

Expand all

External Reference Information

External Reference

UniProt:Q96EZ8 MCRS1

Gene Names

MCRS1, INO80Q, MSP58

Chain

chain:1-462

Reference Genes

BioGPS Gene:10445 MCRS1

COSMIC (genes):MCRS1 MCRS1

CTD Gene:10445 MCRS1

dbSNP Gene:10445 MCRS1

ENSEMBL:ENSG00000187778 MCRS1

HGNC:6960 MCRS1

KEGG:hsa:10445 MCRS1

Monarch:10445 MCRS1

NCBI Gene:10445 MCRS1

OMIM:609504 MCRS1

UCSC:Q96EZ8 MCRS1

Reference Transcript

Other Identifiers

10445

11718162_a_at

16764348

202556_PM_s_at

202556_s_at

33898_at

3453904

3453905

3453906

3453907

3453908

3453909

3453910

3453911

3453912

3453913

3453914

3453915

3453916

3453917

3453918

3453920

3453921

3453922

3453923

3453924

3453925

3453926

3453927

3453928

3453929

3453930

3453933

3453934

3453935

3453936

3453937

7963064

A_23_P48237

GE81623

GO:0000123

GO:0000723

GO:0002151

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0006275

GO:0006281

GO:0006282

GO:0006310

GO:0006325

GO:0006338

GO:0006355

GO:0008266

GO:0010521

GO:0030425

GO:0031011

GO:0032200

GO:0033044

GO:0034046

GO:0036211

GO:0043204

GO:0043226

GO:0044545

GO:0045739

GO:0045893

GO:0045944

GO:0045995

GO:0051726

GO:0060382

GO:0071339

GO:0098772

GO:1904357

GO:1904507

GO:1904751

HMNXSV003025875

ILMN_1713147

ILMN_1784227

PH_hs_0002226

TC12001478.hg

TC12002870.hg

g5453693_3p_a_at

Participates

as a component of

as an input of

Formation of the NSL complex (Homo sapiens)

Inferred To

Mcrs1 [nucleoplasm] (Mus musculus)

Mcrs1 [nucleoplasm] (Rattus norvegicus)

MCRS1 [nucleoplasm] (Bos taurus)

MCRS1 [nucleoplasm] (Canis familiaris)

MCRS1 [nucleoplasm] (Gallus gallus)

MCRS1 [nucleoplasm] (Sus scrofa)

mcrs1 [nucleoplasm] (Xenopus tropicalis)

Rcd5 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

XP_016874178.1, XP_005268629.1, NP_001265270.1, NP_001012300.1, NP_006328.2, XP_016874179.1

OpenTargets

ENSG00000187778

ENSEMBL

ENST00000546244, ENSP00000349640, ENSP00000444982, ENST00000357123, ENST00000343810, ENSP00000448056, ENSP00000345358, ENST00000550165

HPA

ENSG00000187778-MCRS1

PRO

Q96EZ8

Pharos - Targets

Q96EZ8

Interactors (126)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y3C0 WASC3			0.879	13
UniProt:Q8NBZ0 INO80E	1	INO80E [nucleoplasm] (R-HSA-5689552)	0.845	11
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.793	11
UniProt:Q8N6Y0 USBP1			0.718	6
UniProt:O15209 ZBT22			0.718	6
UniProt:Q9Y2W2 WBP11	1	WBP11 [nucleoplasm] (R-HSA-8867887)	0.696	5
UniProt:Q86WP2 GPBP1			0.696	5
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.671	4
UniProt:Q9BQD3 KXDL1			0.666	4
UniProt:Q96S65 CSRN1			0.666	4
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.666	4
UniProt:O94972 TRIM37	1	TRIM37 [cytosol] (R-HSA-976049)	0.666	4
UniProt:P57055 DSCR6			0.666	4
UniProt:P51116 FXR2			0.666	4
UniProt:Q2T9L4 INSY1			0.666	4
UniProt:Q13422 IKZF1			0.666	4
UniProt:Q9C0F1 CEP44			0.666	6
UniProt:Q8TBK6 ZCH10			0.666	4
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.643	3
UniProt:Q96CN9 GCC1	1	GCC1 [cytosol] (R-HSA-6813877)	0.621	3
UniProt:Q9D1P2	1	KAT8 [nucleoplasm] (R-MMU-3321802)	0.564	2
UniProt:Q6NT76 HMBX1			0.556	8
UniProt:O60759 CYTIP			0.556	3
UniProt:Q92764 KRT35	1	KRT35 [cytosol] (R-HSA-6809595)	0.556	3
UniProt:P38432 COIL			0.556	3
UniProt:Q86TJ2-3 Q86TJ23			0.556	3
UniProt:P19237 TNNI1	1	TNNI1 [cytosol] (R-HSA-390539)	0.556	3
UniProt:Q8TD31-3 CCHCR1			0.556	3
UniProt:P51114-2 FXR1			0.556	3
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.556	3
UniProt:Q8N137 CNTRB			0.556	3
UniProt:A7MD48 SRRM4			0.556	3
UniProt:Q9BYR9 KRTAP2-4	1	KRTAP2-4 [cytosol] (R-HSA-6809951)	0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:Q53TS8 CTSRT			0.556	3
UniProt:Q96KB5 TOPK			0.556	3
UniProt:Q9HCU9 BRMS1	1	BRMS1 [nucleoplasm] (R-HSA-4650034)	0.556	3
UniProt:O60861-1 GAS7			0.556	3
UniProt:Q14919 DRAP1	1	DRAP1 [nucleoplasm] (R-HSA-1226029)	0.556	3
UniProt:Q8IZU1 FAM9A			0.556	3
UniProt:O43586 PSTPIP1	1	PSTPIP1 [cytosol] (R-HSA-879220)	0.556	3
UniProt:Q86VR2 RETR3			0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q8N302 AGGF1	2	AGGF(1-290)-RAF1(279-648) fusion [cytosol] (R-HSA-6802255) AGGF(1-290)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802507)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q9H0E9-2 BRD8			0.556	3
UniProt:Q5PSV4 BRM1L			0.556	5
UniProt:Q8NA61-2 CBY2			0.556	3
UniProt:Q86TI0 TBC1D1	2	TBC1D1 [cytoplasmic vesicle membrane] (R-HSA-1454718) p-S237-TBC1D1 [cytosol] (R-HSA-1454673)	0.556	3
UniProt:P45984 MAPK9	3	MAPK9 [cytosol] (R-HSA-450355) p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319)	0.556	3
UniProt:Q6PEW1 ZCH12			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.556	3
UniProt:P10276 RARA	3	RARA [nucleoplasm] (R-HSA-446164) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830)	0.556	3
UniProt:O75971-2 SNAPC5			0.556	3
UniProt:Q15276 RABEP1	1	RABEP1 [early endosome membrane] (R-HSA-2029004)	0.556	3
IntAct:EBI-16435328 CCSB ORF ID			0.556	3
UniProt:Q96KQ4 PPP1R13B	1	PPP1R13B [nucleoplasm] (R-HSA-6799775)	0.556	3
UniProt:Q01664 TFAP4			0.556	3
UniProt:Q9H2S9 IKZF4			0.556	3
UniProt:Q9H3D4 TP63	1	TP63 [nucleoplasm] (R-HSA-2997585)	0.556	3
UniProt:Q13422-7 IKZF1			0.556	3
UniProt:Q15025 TNIP1	1	TNIP1 [cytosol] (R-HSA-5690853)	0.556	3
UniProt:Q8IYE1 CCD13			0.556	6
UniProt:Q9Y250 LZTS1			0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
IntAct:EBI-23710320 CCSB ORF ID			0.556	3
UniProt:Q96KN3 PKNX2			0.556	3
UniProt:Q02446 SP4			0.556	3
UniProt:Q96GN5 CDA7L			0.556	6
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:Q8TC99 FNDC8			0.556	3
UniProt:Q9BYV9 BACH2			0.556	3
UniProt:Q9H257-2 CARD9			0.556	3
UniProt:Q4G0R1 Q4G0R1			0.556	3
UniProt:O95251 KAT7	1	KAT7 [nucleoplasm] (R-HSA-3321823)	0.556	3
UniProt:Q5T5X7 BEND3			0.556	3
UniProt:Q8N344 MIER2			0.556	5
UniProt:O95810 CAVN2			0.556	3
UniProt:O75420 GGYF1			0.556	3
UniProt:P01112 HRAS	20	S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912) proHRAS [cytosol] (R-HSA-9647765) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS [plasma membrane] (R-HSA-62717) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G13R [plasma membrane] (R-HSA-6802368)	0.556	3
UniProt:Q9H4L5 OSBPL3	1	OSBPL3 [cytosol] (R-HSA-8867532)	0.556	3
UniProt:Q96ED9-2 HOOK2			0.556	3
IntAct:EBI-22395812 CCSB ORF ID			0.556	3
UniProt:P17098 ZNF8			0.556	3
UniProt:P41227 NAA10			0.556	3
IntAct:EBI-23624784 CCSB ORF ID			0.556	3
UniProt:Q96N16 JKIP1			0.556	3
UniProt:Q9UID6 ZN639			0.556	3
UniProt:Q8N8K9 K1958			0.556	3
UniProt:P51946 CCNH	1	CCNH [nucleoplasm] (R-HSA-69220)	0.556	3
UniProt:P43360 MAGA6			0.556	3
UniProt:Q6ZUT1 NKAP1			0.556	6
UniProt:Q96B23 ARK2N			0.556	5
UniProt:A1L4K1 FSD2			0.556	3
UniProt:Q8WWF3 SSMM1			0.556	3
UniProt:Q15154-3 PCM1			0.556	3
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:P50548 ERF	3	p-T526-ERF [nucleoplasm] (R-HSA-3209166) p-T526-ERF [cytosol] (R-HSA-3209167) ERF [nucleoplasm] (R-HSA-2534321)	0.556	3
UniProt:Q9Y2T1 AXIN2	4	AXIN2 [cytosol] (R-HSA-3640821) ub-AXIN2 [cytosol] (R-HSA-4641131) RibC-AXIN2 [cytosol] (R-HSA-3640842) Ub-RibC-AXIN2 [cytosol] (R-HSA-3640859)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:Q68CJ9 CREB3L3	10	CREB3L3(1-?) [nucleoplasm] (R-HSA-6784629) CREB3L3(1-?) [cytosol] (R-HSA-6784654) CREB3L3 [endoplasmic reticulum membrane] (R-HSA-6784669) CREB3L3(?-461) [endoplasmic reticulum membrane] (R-HSA-6784710) CREB3L3 [Golgi membrane] (R-HSA-8874144) CREB3L3(365-461) [Golgi membrane] (R-HSA-8874130) CREB3L3(1-364) [Golgi membrane] (R-HSA-8874158) CREB3L3(1-323) [cytosol] (R-HSA-8874214) CREB3L3(1-323) [nucleoplasm] (R-HSA-8874217) CREB3L3(324-364) [Golgi membrane] (R-HSA-8874183)	0.556	3
UniProt:Q9H2G4 TSPYL2	1	TSPYL2 [nucleoplasm] (R-HSA-535540)	0.556	5
UniProt:P55081 MFAP1	1	MFAP1 [nucleoplasm] (R-HSA-2396419)	0.556	3
UniProt:P98170 XIAP	3	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366)	0.556	3
UniProt:Q7Z3K6-2 MIER3			0.556	3
UniProt:Q7RTU4 BHA09			0.556	3
UniProt:P50221 MEOX1			0.556	3
UniProt:O14492-2 O144922			0.556	3
UniProt:Q63ZY3 KANK2			0.556	3
UniProt:Q8WV44 TRIM41	1	TRIM41 [cytosol] (R-HSA-5688975)	0.556	3
UniProt:O60447 EVI5			0.556	3
UniProt:P17027 ZNF23	1	ZNF23 [nucleoplasm] (R-HSA-1027395)	0.556	3
UniProt:P0C1Z6 TFPT	1	TFPT [nucleoplasm] (R-HSA-5689542)	0.527	2
UniProt:Q9ULG1 INO80	1	INO80 [nucleoplasm] (R-HSA-5688910)	0.527	2
UniProt:Q6PI98 INO80C	1	INO80C [nucleoplasm] (R-HSA-5689605)	0.527	2
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.527	2
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.527	4
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.527	3
UniProt:Q8IXK0 PHC2	1	PHC2 [nucleoplasm] (R-HSA-389112)	0.508	2

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