Reactome | ACTB [nucleoplasm]

ACTB [nucleoplasm]

Stable Identifier

R-HSA-3321990

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

beta-actin, cytoplasmic actin 1

Icon

Locations in the PathwayBrowser for interactor UniProt:P23528 CFL1

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External Reference Information

External Reference

UniProt:P60709 ACTB

Gene Names

ACTB

Chain

chain:1-375, initiator methionine:, chain:2-375

Reference Genes

BioGPS Gene:60 ACTB

COSMIC (genes):ACTB ACTB

CTD Gene:60 ACTB

dbSNP Gene:60 ACTB

ENSEMBL:ENSG00000075624 ACTB

ENSEMBL_homo_sapiens_GENE:ENSG00000075624.17 ACTB

HGNC:132 ACTB

KEGG Gene (Homo sapiens):60 ACTB

Monarch:60 ACTB

NCBI Gene:60 ACTB

OMIM:102630 ACTB

Reference Transcript

RefSeq:NM_001101.3 ACTB

Other Identifiers

11720754_x_at

11752865_x_at

11756071_x_at

200801_PM_x_at

200801_x_at

213867_PM_x_at

213867_x_at

224594_PM_x_at

224594_x_at

2419182

2457900

2457901

2816906

2816908

2963900

3036925

3036926

3036927

3036928

3036930

3036933

3036934

3036935

3036937

3036938

3036939

3036940

3036941

3036942

3036944

3036945

32318_s_at

3712504

3975446

64355_s_at

8137979

AFFX-HSAC07/X00351_3_at

AFFX-HSAC07/X00351_5_at

AFFX-HSAC07/X00351_M_at

A_23_P135769

A_23_P31323

A_24_P226554

GE545663

GO:0000079

GO:0000166

GO:0000278

GO:0000776

GO:0000785

GO:0000786

GO:0001738

GO:0002376

GO:0003677

GO:0003824

GO:0005198

GO:0005200

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005903

GO:0005911

GO:0005912

GO:0005925

GO:0006281

GO:0006310

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006357

GO:0007010

GO:0007059

GO:0007155

GO:0007163

GO:0007409

GO:0008092

GO:0008284

GO:0012501

GO:0015629

GO:0016020

GO:0016192

GO:0016363

GO:0016514

GO:0016586

GO:0016787

GO:0019894

GO:0019901

GO:0021762

GO:0022898

GO:0030027

GO:0030071

GO:0030154

GO:0030424

GO:0030863

GO:0030957

GO:0031492

GO:0031982

GO:0032091

GO:0032991

GO:0034330

GO:0034333

GO:0035060

GO:0035267

GO:0035633

GO:0036211

GO:0036464

GO:0042060

GO:0042802

GO:0042981

GO:0043226

GO:0043296

GO:0044305

GO:0045176

GO:0045202

GO:0045582

GO:0045596

GO:0045597

GO:0045663

GO:0045893

GO:0048156

GO:0048856

GO:0048870

GO:0050998

GO:0051621

GO:0051623

GO:0051726

GO:0055085

GO:0070062

GO:0070160

GO:0070316

GO:0070527

GO:0071564

GO:0071565

GO:0071896

GO:0072562

GO:0072659

GO:0072749

GO:0097433

GO:0098685

GO:0098793

GO:0098871

GO:0098973

GO:0098974

GO:0098978

GO:0140092

GO:0140288

GO:0150111

GO:1900242

GO:1902459

GO:1903076

GO:1905168

GO:1990904

GO:2000045

GO:2000779

GO:2000781

GO:2000819

HMNXSV003033669

HMNXSV003057774

Hs.288061.2.A1_3p_s_at

ILMN_1777296

ILMN_2038777

ILMN_2152131

M10277_s_at

PH_hs_0030148

TC07001120.hg

TC07002772.hg

TC07002773.hg

X00351_f_at

g12408251_3p_s_at

g5016088_3p_x_at

Participates

as an output of

B-WICH complex binds rDNA promoter (Homo sapiens)

as a component of

Other forms of this molecule

Unfolded ACTB [cytosol]

ACTB [cytosol]

ACTB [lysosomal membrane]

ACTB [plasma membrane]

Inferred To

ACTB [nucleoplasm] (Bos taurus)

ACTB [nucleoplasm] (Canis familiaris)

ACTB [nucleoplasm] (Gallus gallus)

ACTB [nucleoplasm] (Sus scrofa)

act26 [nucleoplasm] (Dictyostelium discoideum)

actba [nucleoplasm] (Danio rerio)

Act5C [nucleoplasm] (Drosophila melanogaster)

actg1 [nucleoplasm] (Xenopus tropicalis)

Actb [nucleoplasm] (Mus musculus)

Actb [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001092.1

OpenTargets

ENSG00000075624

GeneCards

P60709

HPA

ENSG00000075624-ACTB

Ensembl

ENSP00000495995, ENST00000674681, ENSP00000494750, ENST00000642480, ENSP00000494269, ENSP00000501862, ENST00000646664, ENSP00000502821, ENST00000493945, ENSG00000075624, ENST00000675515

PRO

P60709

Pharos - Targets

P60709

Orphanet

17409

PDB

7Y8R, 6LTJ, 7AS4, 8OI8, 6V62, 8VRK, 8RTT, 6OX4, 6NBW, 7QJ6, 7P1H, 6V63, 6ICV, 6OX5, 7VDV, 8X1C, 7W28, 3J82, 8RTY, 6MBK, 6OX0, 8DNH, 6ANU, 3BYH, 8OID, 6ICT, 7QJ9, 7W29, 8VRD, 6MBJ, 6OX1, 8RU2, 6WK1, 7ZTC, 7ZTD, 8COG, 6OX2, 6WK2, 3LUE, 6MBL, 8VRJ, 8X19, 6OX3, 3D2U, 8X15

Interactors (82)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB [nucleoplasm] (R-HSA-3321990) ACTB [cytosol] (R-HSA-201861) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [plasma membrane] (R-HSA-196016)	0.955	16
UniProt:P63261 ACTG1	3	ACTG1 [cytosol] (R-HSA-201858) ACTG1 [lysosomal membrane] (R-HSA-196169) ACTG1 [plasma membrane] (R-HSA-196044)	0.951	16
UniProt:P23528 CFL1	3	CFL1 [cytosol] (R-HSA-350751) p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [extracellular region] (R-HSA-350747)	0.933	11
UniProt:Q9Y281 COF2			0.913	11
UniProt:P60981 DEST			0.904	10
UniProt:P40123 CAP2	1	CAP2 [cytosol] (R-HSA-428863)	0.818	9
UniProt:Q96HA8 NTAQ1			0.742	6
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.731	6
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.723	6
UniProt:P07737 PFN1	2	PFN1 [cytosol] (R-HSA-203081) PFN1 [extracellular region] (R-HSA-350755)	0.693	3
UniProt:Q8WTR2 DUS19			0.666	4
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.666	4
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.666	8
UniProt:Q6IBS0 TWF2	1	TWF2 [cytosol] (R-HSA-9663291)	0.643	4
UniProt:Q9NYL9 TMOD3	1	TMOD3 [cytosol] (R-HSA-217354)	0.643	4
UniProt:O75167 PHACTR2	2	PHACTR2 [plasma membrane] (R-HSA-8848883) PHACTR2 [platelet alpha granule membrane] (R-HSA-8848893)	0.643	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.643	5
UniProt:P08413 Camk2b	7	phospho-p-T287-CAMK2B [plasma membrane] (R-RNO-432791) phospho-p-T287-CAMK2B [nucleoplasm] (R-RNO-444787) phospho-p-T287-CAMK2B [endocytic vesicle membrane] (R-RNO-417009) p-T287-Camk2b [cytosol] (R-RNO-9618634) Camk2b [cytosol] (R-RNO-9611391) CAMK2B [cytosol] (R-RNO-9611360) phospho-p-T287-CAMK2B [cytosol] (R-RNO-445371)	0.615	4
UniProt:Q92731 ESR2	5	PalmS-ESR2 [cytosol] (R-HSA-9020979) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.597	6
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.573	2
UniProt:P13693 TCTP			0.567	4
UniProt:O75083 WDR1	2	WDR1 [extracellular region] (R-HSA-350752) WDR1 [cytosol] (R-HSA-350699)	0.564	2
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.564	3
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.564	2
UniProt:P14598 NCF1	4	NCF1 [cytosol] (R-HSA-1222296) p-6S-NCF1 [phagolysosome] (R-HSA-1996220) p-S345-NCF1 [cytosol] (R-HSA-9626824) p-6S-NCF1 [cytosol] (R-HSA-9626854)	0.558	3
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	3
UniProt:Q9UBQ0-2 VPS29			0.556	3
UniProt:Q02821	2	SRP1 [cytosol] (R-SCE-180612) SRP1 [cytosol] (R-SCE-9734672)	0.556	3
UniProt:P46680	2	AIP1 [extracellular region] (R-SCE-350752) AIP1 [cytosol] (R-SCE-350699)	0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:P38340 NTM1			0.556	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.556	3
UniProt:P60010	1	ACT1 [cytosol] (R-SCE-390536)	0.556	3
UniProt:Q549N0 Q549N0			0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q9PTD7 CING			0.544	2
UniProt:O14950 MYL12B	3	MYL12B [cytosol] (R-HSA-390727) p-T19,S20-MYL12B [cytosol] (R-HSA-390751) p-T19-MYL12B [cytosol] (R-HSA-5668936)	0.537	3
UniProt:P83110 HTRA3			0.537	5
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.537	10
UniProt:Q8TCA0 LRC20			0.527	3
UniProt:Q01518 CAP1	3	CAP1 [cytosol] (R-HSA-350758) CAP1 [extracellular region] (R-HSA-350746) CAP1 [azurophil granule lumen] (R-HSA-6798752)	0.527	4
UniProt:P12724 RNASE3	2	RNASE3 [azurophil granule lumen] (R-HSA-6799158) RNASE3 [extracellular region] (R-HSA-6803115)	0.527	2
UniProt:Q08AE8 SPIR1			0.527	2
UniProt:Q0ZGT2 NEXN			0.527	2
UniProt:P24666 PPAC			0.527	2
UniProt:P06213-PRO_0000016689 INSR			0.527	3
UniProt:Q9Y6U3 SCIN			0.527	2
UniProt:Q8WYL5 SSH1			0.527	2
UniProt:Q14667 BLTP2			0.527	3
UniProt:Q8ND90 PNMA1			0.527	2
UniProt:Q02978 SLC25A11	1	SLC25A11 [mitochondrial inner membrane] (R-HSA-198451)	0.527	2
UniProt:O75069 TMCC2			0.527	4
UniProt:Q9Y6R4 M3K4			0.527	4
UniProt:O95084 PRSS23	2	p-PRSS23 [endoplasmic reticulum lumen] (R-HSA-8956908) PRSS23 [endoplasmic reticulum lumen] (R-HSA-8956760)	0.527	2
UniProt:Q8NG41 NPB	2	NPB(25-48) [extracellular region] (R-HSA-374794) NPB(25-53) [extracellular region] (R-HSA-374790)	0.527	2
UniProt:P0DN37 PAL4G			0.527	2
UniProt:Q3KR16 PLEKHG6	1	PLEKHG6 [cytosol] (R-HSA-9714266)	0.527	2
UniProt:P43363 MAGAA			0.527	2
UniProt:Q8TB52 FBXO30	1	FBXO30 [cytosol] (R-HSA-8862619)	0.527	3
UniProt:Q9Y6W6 DUSP10	2	DUSP10 [cytosol] (R-HSA-5675334) DUSP10 [nucleoplasm] (R-HSA-203793)	0.527	2
UniProt:Q765P7 MTSS2			0.527	2
UniProt:Q8TD22 SFXN5			0.527	2
UniProt:P35080 PFN2	1	PFN2 [cytosol] (R-HSA-3009037)	0.527	2
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.527	2
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.527	5
UniProt:Q06141 REG3A	3	REG3A(38-175) [extracellular region] (R-HSA-6801352) REG3A(27-37) [extracellular region] (R-HSA-6801783) REG3A(27-175) [extracellular region] (R-HSA-6801803)	0.527	2
UniProt:Q14686 NCOA6	1	NCOA6 [nucleoplasm] (R-HSA-376414)	0.527	2
UniProt:P02774 GC	3	GC [lysosomal lumen] (R-HSA-350137) GC [cytosol] (R-HSA-209929) GC [extracellular region] (R-HSA-209886)	0.527	4
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.527	3
UniProt:P10828 THRB	3	polySUMO3-K50,K146,K443-THRB [nucleoplasm] (R-HSA-4719433) monoSUMO1-K50,K146,K443-THRB [nucleoplasm] (R-HSA-4719421) THRB [nucleoplasm] (R-HSA-446179)	0.527	2
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.524	2
UniProt:P83110-2 HTRA3			0.512	3
UniProt:Q9WMX2-PRO_0000037551			0.508	3
UniProt:Q9BSI4 TINF2	1	TINF2 [nucleoplasm] (R-HSA-174883)	0.508	2
IntAct:EBI-6863782 NS3			0.499	2
UniProt:Q92636 NSMAF	1	NSMAF [cytosol] (R-HSA-5626992)	0.499	2
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.491	2
UniProt:P11275 Camk2a	6	phospho-p-T286-CAMK2A [plasma membrane] (R-RNO-432796) phospho-p-T286-CAMK2A [nucleoplasm] (R-RNO-444797) phospho-p-T286-CAMK2A [endocytic vesicle membrane] (R-RNO-416999) phospho-p-T286,T305,T306-CAMK2A [cytosol] (R-RNO-4332334) Camk2a [cytosol] (R-RNO-9611390) p-T286-Camk2a [cytosol] (R-RNO-9618632)	0.488	2
UniProt:Q8TCJ0 FBX25			0.463	2
UniProt:Q8K430 KLH17			0.463	2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2

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