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ACTB [nucleoplasm]
Stable Identifier
R-HSA-3321990
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
beta-actin, cytoplasmic actin 1
Icon
Locations in the PathwayBrowser for interactor UniProt:Q01518 CAP1
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Positive epigenetic regulation of rRNA expression (Homo sapiens)
B-WICH complex positively regulates rRNA expression (Homo sapiens)
B-WICH complex binds rDNA promoter (Homo sapiens)
ACTB [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P60709 ACTB
Gene Names
ACTB
Chain
chain:1-375, initiator methionine:, chain:2-375
Reference Genes
BioGPS Gene:60 ACTB
COSMIC (genes):ACTB ACTB
CTD Gene:60 ACTB
dbSNP Gene:60 ACTB
ENSEMBL:ENSG00000075624 ACTB
HGNC:132 ACTB
KEGG:hsa:60 ACTB
Monarch:60 ACTB
NCBI Gene:60 ACTB
OMIM:102630 ACTB
UCSC:P60709 ACTB
Reference Transcript
RefSeq:NM_001101.3 ACTB
Other Identifiers
11720754_x_at
11752865_x_at
11756071_x_at
17054823
200801_PM_x_at
200801_x_at
213867_PM_x_at
213867_x_at
224594_PM_x_at
224594_x_at
2419182
2457900
2457901
2816906
2816908
2963900
3036925
3036926
3036927
3036928
3036929
3036930
3036931
3036932
3036933
3036934
3036935
3036936
3036937
3036938
3036939
3036940
3036941
3036942
3036944
3036945
3036946
3036961
32318_s_at
3712504
3975446
60
64355_s_at
8137979
AFFX-HSAC07/X00351_3_at
AFFX-HSAC07/X00351_5_at
AFFX-HSAC07/X00351_M_at
A_23_P135769
A_23_P31323
A_24_P226554
GE545663
GO:0000079
GO:0000776
GO:0000785
GO:0000786
GO:0001738
GO:0003677
GO:0003824
GO:0005198
GO:0005200
GO:0005515
GO:0005524
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0005903
GO:0005911
GO:0005912
GO:0005925
GO:0006325
GO:0006338
GO:0006355
GO:0006357
GO:0007155
GO:0007163
GO:0007409
GO:0008092
GO:0008284
GO:0015629
GO:0016020
GO:0016363
GO:0016514
GO:0016586
GO:0016787
GO:0016887
GO:0019894
GO:0019901
GO:0021762
GO:0022898
GO:0030027
GO:0030071
GO:0030424
GO:0030863
GO:0030957
GO:0031492
GO:0031982
GO:0032091
GO:0032991
GO:0034330
GO:0034333
GO:0035060
GO:0035267
GO:0035633
GO:0036464
GO:0042802
GO:0042981
GO:0043226
GO:0043296
GO:0044305
GO:0045176
GO:0045202
GO:0045582
GO:0045596
GO:0045597
GO:0045663
GO:0045893
GO:0048156
GO:0048856
GO:0048870
GO:0050998
GO:0051621
GO:0051623
GO:0051726
GO:0070062
GO:0070160
GO:0070316
GO:0070527
GO:0071564
GO:0071565
GO:0071896
GO:0072562
GO:0072749
GO:0097433
GO:0098685
GO:0098793
GO:0098871
GO:0098973
GO:0098978
GO:0140092
GO:0140288
GO:0150111
GO:1900242
GO:1902459
GO:1903076
GO:1905168
GO:1990904
GO:2000045
GO:2000779
GO:2000781
GO:2000819
HMNXSV003033669
HMNXSV003057774
Hs.288061.2.A1_3p_s_at
ILMN_1777296
ILMN_2038777
ILMN_2152131
M10277_s_at
PH_hs_0030148
TC07001120.hg
TC07002772.hg
TC07002773.hg
X00351_f_at
g12408251_3p_s_at
g5016088_3p_x_at
Participates
as an output of
B-WICH complex binds rDNA promoter (Homo sapiens)
as a component of
MYO1C:ACTB [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
NuA4 [nucleoplasm] (Homo sapiens)
INO80 complex [nucleoplasm] (Homo sapiens)
Other forms of this molecule
ACTB [plasma membrane]
ACTB [lysosomal membrane]
ACTB [cytosol]
Unfolded ACTB [cytosol]
Inferred To
ACTB [nucleoplasm]
(Bos taurus)
ACTB [nucleoplasm]
(Canis familiaris)
ACTB [nucleoplasm]
(Gallus gallus)
ACTB [nucleoplasm]
(Sus scrofa)
act26 [nucleoplasm]
(Dictyostelium discoideum)
actba [nucleoplasm]
(Danio rerio)
Act5C [nucleoplasm]
(Drosophila melanogaster)
actg1 [nucleoplasm]
(Xenopus tropicalis)
Actb [nucleoplasm]
(Mus musculus)
Actb [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_001092.1
OpenTargets
ENSG00000075624
ENSEMBL
ENSP00000502821
,
ENSP00000494269
,
ENST00000675515
,
ENST00000642480
,
ENST00000646664
,
ENSP00000495995
,
ENSP00000494750
,
ENST00000674681
,
ENSP00000501862
,
ENST00000493945
HPA
ENSG00000075624-ACTB
PRO
P60709
Pharos - Targets
P60709
GlyGen
P60709
Orphanet
ACTB
PDB
6LTJ
,
7W29
,
6V62
,
6V63
,
8IB8
,
6ICV
,
3D2U
,
6OX5
,
3LUE
,
8RTT
,
6ICT
,
8X15
,
7VDV
,
6ANU
,
8VRD
,
7W28
,
8X19
,
8X1C
,
8DNH
,
6MBJ
,
8RU2
,
8VRK
,
8VRJ
,
7Y8R
,
8RTY
,
8COG
,
8OID
,
3J82
,
6WK2
,
7ZTC
,
6MBL
,
6MBK
,
6OX0
,
6OX4
,
6OX3
,
6WK1
,
3BYH
,
6NBW
,
7QJ6
,
6OX2
,
8OI8
,
6OX1
,
7P1H
,
7QJ9
,
7AS4
,
7ZTD
Interactors (82)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60709 ACTB
5
ACTB [plasma membrane]
(R-HSA-196016)
ACTB [lysosomal membrane]
(R-HSA-196160)
ACTB [cytosol]
(R-HSA-201861)
ACTB [nucleoplasm]
(R-HSA-3321990)
Unfolded ACTB [cytosol]
(R-HSA-390462)
0.955
16
UniProt:P63261 ACTG1
3
ACTG1 [plasma membrane]
(R-HSA-196044)
ACTG1 [lysosomal membrane]
(R-HSA-196169)
ACTG1 [cytosol]
(R-HSA-201858)
0.951
16
UniProt:P23528 CFL1
3
CFL1 [cytosol]
(R-HSA-350751)
p-S3-CFL1 [cytosol]
(R-HSA-399813)
CFL1 [extracellular region]
(R-HSA-350747)
0.933
11
UniProt:Q9Y281 COF2
0.913
11
UniProt:P60981 DEST
0.904
10
UniProt:P40123 CAP2
1
CAP2 [cytosol]
(R-HSA-428863)
0.818
9
UniProt:Q96HA8 NTAQ1
0.742
6
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.731
6
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.723
6
UniProt:P07737 PFN1
2
PFN1 [cytosol]
(R-HSA-203081)
PFN1 [extracellular region]
(R-HSA-350755)
0.693
3
UniProt:Q08426 EHHADH
2
EHHADH [peroxisomal matrix]
(R-HSA-400155)
EHHADH [cytosol]
(R-HSA-9033147)
0.666
4
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.666
8
UniProt:Q8WTR2 DUS19
0.666
4
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.643
5
UniProt:O75167 PHACTR2
2
PHACTR2 [plasma membrane]
(R-HSA-8848883)
PHACTR2 [platelet alpha granule membrane]
(R-HSA-8848893)
0.643
3
UniProt:Q9NYL9 TMOD3
1
TMOD3 [cytosol]
(R-HSA-217354)
0.643
4
UniProt:Q6IBS0 TWF2
1
TWF2 [cytosol]
(R-HSA-9663291)
0.643
4
UniProt:P08413 Camk2b
7
phospho-p-T287-CAMK2B [plasma membrane]
(R-RNO-432791)
phospho-p-T287-CAMK2B [nucleoplasm]
(R-RNO-444787)
phospho-p-T287-CAMK2B [endocytic vesicle membrane]
(R-RNO-417009)
p-T287-Camk2b [cytosol]
(R-RNO-9618634)
Camk2b [cytosol]
(R-RNO-9611391)
CAMK2B [cytosol]
(R-RNO-9611360)
phospho-p-T287-CAMK2B [cytosol]
(R-RNO-445371)
0.615
4
UniProt:Q92731 ESR2
5
ESR2 [cytosol]
(R-HSA-9020970)
ESR2 [nucleoplasm]
(R-HSA-446165)
Me-PalmS-ESR2 [plasma membrane]
(R-HSA-9637787)
PalmS-ESR2 [plasma membrane]
(R-HSA-9021059)
PalmS-ESR2 [cytosol]
(R-HSA-9020979)
0.597
6
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.573
2
UniProt:P13693 TCTP
0.567
4
UniProt:Q9UQB8 BAIAP2
1
BAIAP2 [cytosol]
(R-HSA-442574)
0.564
2
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.564
3
UniProt:O75083 WDR1
2
WDR1 [extracellular region]
(R-HSA-350752)
WDR1 [cytosol]
(R-HSA-350699)
0.564
2
UniProt:P14598 NCF1
4
p-S345-NCF1 [cytosol]
(R-HSA-9626824)
p-6S-NCF1 [cytosol]
(R-HSA-9626854)
NCF1 [cytosol]
(R-HSA-1222296)
p-6S-NCF1 [phagolysosome]
(R-HSA-1996220)
0.558
3
UniProt:P78317 RNF4
2
RNF4 [nucleoplasm]
(R-HSA-5684076)
RNF4 [cytosol]
(R-HSA-975974)
0.556
3
UniProt:Q9UBQ0-2 VPS29
0.556
3
UniProt:Q02821
2
SRP1 [cytosol]
(R-SCE-180612)
SRP1 [cytosol]
(R-SCE-9734672)
0.556
3
UniProt:P46680
2
AIP1 [extracellular region]
(R-SCE-350752)
AIP1 [cytosol]
(R-SCE-350699)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:Q549N0 Q549N0
0.556
3
UniProt:P60010
1
ACT1 [cytosol]
(R-SCE-390536)
0.556
3
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.556
3
UniProt:P38340 NTM1
0.556
3
UniProt:Q7KZS0 Q7KZS0
0.556
3
UniProt:Q9PTD7 CING
0.544
2
UniProt:O14950 MYL12B
3
p-T19-MYL12B [cytosol]
(R-HSA-5668936)
p-T19,S20-MYL12B [cytosol]
(R-HSA-390751)
MYL12B [cytosol]
(R-HSA-390727)
0.537
3
UniProt:P83110 HTRA3
0.537
5
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.537
10
UniProt:Q8TCA0 LRC20
0.527
3
UniProt:Q01518 CAP1
3
CAP1 [azurophil granule lumen]
(R-HSA-6798752)
CAP1 [extracellular region]
(R-HSA-350746)
CAP1 [cytosol]
(R-HSA-350758)
0.527
4
UniProt:P12724 RNASE3
2
RNASE3 [azurophil granule lumen]
(R-HSA-6799158)
RNASE3 [extracellular region]
(R-HSA-6803115)
0.527
2
UniProt:Q08AE8 SPIR1
0.527
2
UniProt:Q0ZGT2 NEXN
0.527
2
UniProt:P24666 PPAC
0.527
2
UniProt:P06213-PRO_0000016689 INSR
0.527
3
UniProt:Q9Y6U3 SCIN
0.527
2
UniProt:Q8WYL5 SSH1
0.527
2
UniProt:Q14667 BLTP2
0.527
3
UniProt:Q8ND90 PNMA1
0.527
2
UniProt:Q02978 SLC25A11
1
SLC25A11 [mitochondrial inner membrane]
(R-HSA-198451)
0.527
2
UniProt:O75069 TMCC2
0.527
4
UniProt:Q9Y6R4 M3K4
0.527
4
UniProt:O95084 PRSS23
2
p-PRSS23 [endoplasmic reticulum lumen]
(R-HSA-8956908)
PRSS23 [endoplasmic reticulum lumen]
(R-HSA-8956760)
0.527
2
UniProt:Q8NG41 NPB
2
NPB(25-48) [extracellular region]
(R-HSA-374794)
NPB(25-53) [extracellular region]
(R-HSA-374790)
0.527
2
UniProt:P0DN37 PAL4G
0.527
2
UniProt:Q3KR16 PLEKHG6
1
PLEKHG6 [cytosol]
(R-HSA-9714266)
0.527
2
UniProt:P43363 MAGAA
0.527
2
UniProt:Q14686 NCOA6
1
NCOA6 [nucleoplasm]
(R-HSA-376414)
0.527
2
UniProt:Q8TB52 FBXO30
1
FBXO30 [cytosol]
(R-HSA-8862619)
0.527
3
UniProt:Q9Y6W6 DUSP10
2
DUSP10 [nucleoplasm]
(R-HSA-203793)
DUSP10 [cytosol]
(R-HSA-5675334)
0.527
2
UniProt:Q765P7 MTSS2
0.527
2
UniProt:P06396 GSN
7
GSN [cytosol]
(R-HSA-350275)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(200-270) [extracellular region]
(R-HSA-976940)
0.527
3
UniProt:Q8TD22 SFXN5
0.527
2
UniProt:P35080 PFN2
1
PFN2 [cytosol]
(R-HSA-3009037)
0.527
2
UniProt:P02774 GC
3
GC [lysosomal lumen]
(R-HSA-350137)
GC [cytosol]
(R-HSA-209929)
GC [extracellular region]
(R-HSA-209886)
0.527
4
UniProt:P10828 THRB
3
polySUMO3-K50,K146,K443-THRB [nucleoplasm]
(R-HSA-4719433)
monoSUMO1-K50,K146,K443-THRB [nucleoplasm]
(R-HSA-4719421)
THRB [nucleoplasm]
(R-HSA-446179)
0.527
2
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.527
2
UniProt:Q06141 REG3A
3
REG3A(27-37) [extracellular region]
(R-HSA-6801783)
REG3A(27-175) [extracellular region]
(R-HSA-6801803)
REG3A(38-175) [extracellular region]
(R-HSA-6801352)
0.527
2
UniProt:P51532 SMARCA4
1
SMARCA4 [nucleoplasm]
(R-HSA-201686)
0.527
5
UniProt:P50402 EMD
4
EMD [nuclear envelope]
(R-HSA-201573)
EMD [cytosol]
(R-HSA-9613988)
EMD [endoplasmic reticulum membrane]
(R-HSA-9613998)
EMD [endosome membrane]
(R-HSA-9715092)
0.524
2
UniProt:P83110-2 HTRA3
0.512
3
UniProt:Q9WMX2-PRO_0000037551
0.508
3
UniProt:Q9BSI4 TINF2
1
TINF2 [nucleoplasm]
(R-HSA-174883)
0.508
2
IntAct:EBI-6863782 NS3
0.499
2
UniProt:Q92636 NSMAF
1
NSMAF [cytosol]
(R-HSA-5626992)
0.499
2
UniProt:P46940 IQGAP1
3
IQGAP1 [cytosol]
(R-HSA-5626371)
IQGAP1 [secretory granule membrane]
(R-HSA-6804803)
IQGAP1 [plasma membrane]
(R-HSA-381681)
0.491
2
UniProt:P11275 Camk2a
6
phospho-p-T286-CAMK2A [plasma membrane]
(R-RNO-432796)
phospho-p-T286-CAMK2A [nucleoplasm]
(R-RNO-444797)
phospho-p-T286,T305,T306-CAMK2A [cytosol]
(R-RNO-4332334)
phospho-p-T286-CAMK2A [endocytic vesicle membrane]
(R-RNO-416999)
Camk2a [cytosol]
(R-RNO-9611390)
p-T286-Camk2a [cytosol]
(R-RNO-9618632)
0.488
2
UniProt:Q8TCJ0 FBX25
0.463
2
UniProt:Q8K430 KLH17
0.463
2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.462
2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE
0.462
2
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