Reactome | ACTB [nucleoplasm]

ACTB [nucleoplasm]

Stable Identifier

R-HSA-3321990

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

beta-actin, cytoplasmic actin 1

Icon

Locations in the PathwayBrowser for interactor UniProt:Q9Y6R4 M3K4

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External Reference Information

External Reference

UniProt:P60709 ACTB

Gene Names

ACTB

Chain

chain:1-375, initiator methionine:, chain:2-375

Reference Genes

BioGPS Gene:60 ACTB

COSMIC (genes):ACTB ACTB

CTD Gene:60 ACTB

dbSNP Gene:60 ACTB

ENSEMBL:ENSG00000075624 ACTB

HGNC:132 ACTB

KEGG:hsa:60 ACTB

Monarch:60 ACTB

NCBI Gene:60 ACTB

OMIM:102630 ACTB

UCSC:P60709 ACTB

Reference Transcript

RefSeq:NM_001101.3 ACTB

Other Identifiers

11720754_x_at

11752865_x_at

11756071_x_at

17054823

200801_PM_x_at

200801_x_at

213867_PM_x_at

213867_x_at

224594_PM_x_at

224594_x_at

2419182

2457900

2457901

2816906

2816908

2963900

3036925

3036926

3036927

3036928

3036929

3036930

3036931

3036932

3036933

3036934

3036935

3036936

3036937

3036938

3036939

3036940

3036941

3036942

3036944

3036945

3036946

3036961

32318_s_at

3712504

3975446

64355_s_at

8137979

AFFX-HSAC07/X00351_3_at

AFFX-HSAC07/X00351_5_at

AFFX-HSAC07/X00351_M_at

A_23_P135769

A_23_P31323

A_24_P226554

GE545663

GO:0000079

GO:0000776

GO:0000785

GO:0000786

GO:0001738

GO:0003677

GO:0003824

GO:0005198

GO:0005200

GO:0005515

GO:0005524

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005903

GO:0005911

GO:0005912

GO:0005925

GO:0006325

GO:0006338

GO:0006355

GO:0006357

GO:0007155

GO:0007163

GO:0007409

GO:0008092

GO:0008284

GO:0015629

GO:0016020

GO:0016363

GO:0016514

GO:0016586

GO:0016787

GO:0016887

GO:0019894

GO:0019901

GO:0021762

GO:0022898

GO:0030027

GO:0030071

GO:0030424

GO:0030863

GO:0030957

GO:0031492

GO:0031982

GO:0032091

GO:0032991

GO:0034330

GO:0034333

GO:0035060

GO:0035267

GO:0035633

GO:0036464

GO:0042802

GO:0042981

GO:0043226

GO:0043296

GO:0044305

GO:0045176

GO:0045202

GO:0045582

GO:0045596

GO:0045597

GO:0045663

GO:0045893

GO:0048156

GO:0048856

GO:0048870

GO:0050998

GO:0051621

GO:0051623

GO:0051726

GO:0070062

GO:0070160

GO:0070316

GO:0070527

GO:0071564

GO:0071565

GO:0071896

GO:0072562

GO:0072749

GO:0097433

GO:0098685

GO:0098793

GO:0098871

GO:0098973

GO:0098978

GO:0140092

GO:0140288

GO:0150111

GO:1900242

GO:1902459

GO:1903076

GO:1905168

GO:1990904

GO:2000045

GO:2000779

GO:2000781

GO:2000819

HMNXSV003033669

HMNXSV003057774

Hs.288061.2.A1_3p_s_at

ILMN_1777296

ILMN_2038777

ILMN_2152131

M10277_s_at

PH_hs_0030148

TC07001120.hg

TC07002772.hg

TC07002773.hg

X00351_f_at

g12408251_3p_s_at

g5016088_3p_x_at

Participates

as an output of

B-WICH complex binds rDNA promoter (Homo sapiens)

as a component of

Other forms of this molecule

ACTB [plasma membrane]

ACTB [lysosomal membrane]

ACTB [cytosol]

Unfolded ACTB [cytosol]

Inferred To

ACTB [nucleoplasm] (Bos taurus)

ACTB [nucleoplasm] (Canis familiaris)

ACTB [nucleoplasm] (Gallus gallus)

ACTB [nucleoplasm] (Sus scrofa)

act26 [nucleoplasm] (Dictyostelium discoideum)

actba [nucleoplasm] (Danio rerio)

Act5C [nucleoplasm] (Drosophila melanogaster)

actg1 [nucleoplasm] (Xenopus tropicalis)

Actb [nucleoplasm] (Mus musculus)

Actb [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001092.1

OpenTargets

ENSG00000075624

ENSEMBL

ENSP00000502821, ENSP00000494269, ENST00000675515, ENST00000642480, ENST00000646664, ENSP00000495995, ENSP00000494750, ENST00000674681, ENSP00000501862, ENST00000493945

HPA

ENSG00000075624-ACTB

PRO

P60709

Pharos - Targets

P60709

GlyGen

P60709

Orphanet

ACTB

PDB

6LTJ, 7W29, 6V62, 6V63, 8IB8, 6ICV, 3D2U, 6OX5, 3LUE, 8RTT, 6ICT, 8X15, 7VDV, 6ANU, 8VRD, 7W28, 8X19, 8X1C, 8DNH, 6MBJ, 8RU2, 8VRK, 8VRJ, 7Y8R, 8RTY, 8COG, 8OID, 3J82, 6WK2, 7ZTC, 6MBL, 6MBK, 6OX0, 6OX4, 6OX3, 6WK1, 3BYH, 6NBW, 7QJ6, 6OX2, 8OI8, 6OX1, 7P1H, 7QJ9, 7AS4, 7ZTD

Interactors (82)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60709 ACTB	5	ACTB [plasma membrane] (R-HSA-196016) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [cytosol] (R-HSA-201861) ACTB [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462)	0.955	16
UniProt:P63261 ACTG1	3	ACTG1 [plasma membrane] (R-HSA-196044) ACTG1 [lysosomal membrane] (R-HSA-196169) ACTG1 [cytosol] (R-HSA-201858)	0.951	16
UniProt:P23528 CFL1	3	CFL1 [cytosol] (R-HSA-350751) p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [extracellular region] (R-HSA-350747)	0.933	11
UniProt:Q9Y281 COF2			0.913	11
UniProt:P60981 DEST			0.904	10
UniProt:P40123 CAP2	1	CAP2 [cytosol] (R-HSA-428863)	0.818	9
UniProt:Q96HA8 NTAQ1			0.742	6
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.731	6
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.723	6
UniProt:P07737 PFN1	2	PFN1 [cytosol] (R-HSA-203081) PFN1 [extracellular region] (R-HSA-350755)	0.693	3
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.666	4
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.666	8
UniProt:Q8WTR2 DUS19			0.666	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.643	5
UniProt:O75167 PHACTR2	2	PHACTR2 [plasma membrane] (R-HSA-8848883) PHACTR2 [platelet alpha granule membrane] (R-HSA-8848893)	0.643	3
UniProt:Q9NYL9 TMOD3	1	TMOD3 [cytosol] (R-HSA-217354)	0.643	4
UniProt:Q6IBS0 TWF2	1	TWF2 [cytosol] (R-HSA-9663291)	0.643	4
UniProt:P08413 Camk2b	7	phospho-p-T287-CAMK2B [plasma membrane] (R-RNO-432791) phospho-p-T287-CAMK2B [nucleoplasm] (R-RNO-444787) phospho-p-T287-CAMK2B [endocytic vesicle membrane] (R-RNO-417009) p-T287-Camk2b [cytosol] (R-RNO-9618634) Camk2b [cytosol] (R-RNO-9611391) CAMK2B [cytosol] (R-RNO-9611360) phospho-p-T287-CAMK2B [cytosol] (R-RNO-445371)	0.615	4
UniProt:Q92731 ESR2	5	ESR2 [cytosol] (R-HSA-9020970) ESR2 [nucleoplasm] (R-HSA-446165) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979)	0.597	6
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.573	2
UniProt:P13693 TCTP			0.567	4
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.564	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	3
UniProt:O75083 WDR1	2	WDR1 [extracellular region] (R-HSA-350752) WDR1 [cytosol] (R-HSA-350699)	0.564	2
UniProt:P14598 NCF1	4	p-S345-NCF1 [cytosol] (R-HSA-9626824) p-6S-NCF1 [cytosol] (R-HSA-9626854) NCF1 [cytosol] (R-HSA-1222296) p-6S-NCF1 [phagolysosome] (R-HSA-1996220)	0.558	3
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	3
UniProt:Q9UBQ0-2 VPS29			0.556	3
UniProt:Q02821	2	SRP1 [cytosol] (R-SCE-180612) SRP1 [cytosol] (R-SCE-9734672)	0.556	3
UniProt:P46680	2	AIP1 [extracellular region] (R-SCE-350752) AIP1 [cytosol] (R-SCE-350699)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q549N0 Q549N0			0.556	3
UniProt:P60010	1	ACT1 [cytosol] (R-SCE-390536)	0.556	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.556	3
UniProt:P38340 NTM1			0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:Q9PTD7 CING			0.544	2
UniProt:O14950 MYL12B	3	p-T19-MYL12B [cytosol] (R-HSA-5668936) p-T19,S20-MYL12B [cytosol] (R-HSA-390751) MYL12B [cytosol] (R-HSA-390727)	0.537	3
UniProt:P83110 HTRA3			0.537	5
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.537	10
UniProt:Q8TCA0 LRC20			0.527	3
UniProt:Q01518 CAP1	3	CAP1 [azurophil granule lumen] (R-HSA-6798752) CAP1 [extracellular region] (R-HSA-350746) CAP1 [cytosol] (R-HSA-350758)	0.527	4
UniProt:P12724 RNASE3	2	RNASE3 [azurophil granule lumen] (R-HSA-6799158) RNASE3 [extracellular region] (R-HSA-6803115)	0.527	2
UniProt:Q08AE8 SPIR1			0.527	2
UniProt:Q0ZGT2 NEXN			0.527	2
UniProt:P24666 PPAC			0.527	2
UniProt:P06213-PRO_0000016689 INSR			0.527	3
UniProt:Q9Y6U3 SCIN			0.527	2
UniProt:Q8WYL5 SSH1			0.527	2
UniProt:Q14667 BLTP2			0.527	3
UniProt:Q8ND90 PNMA1			0.527	2
UniProt:Q02978 SLC25A11	1	SLC25A11 [mitochondrial inner membrane] (R-HSA-198451)	0.527	2
UniProt:O75069 TMCC2			0.527	4
UniProt:Q9Y6R4 M3K4			0.527	4
UniProt:O95084 PRSS23	2	p-PRSS23 [endoplasmic reticulum lumen] (R-HSA-8956908) PRSS23 [endoplasmic reticulum lumen] (R-HSA-8956760)	0.527	2
UniProt:Q8NG41 NPB	2	NPB(25-48) [extracellular region] (R-HSA-374794) NPB(25-53) [extracellular region] (R-HSA-374790)	0.527	2
UniProt:P0DN37 PAL4G			0.527	2
UniProt:Q3KR16 PLEKHG6	1	PLEKHG6 [cytosol] (R-HSA-9714266)	0.527	2
UniProt:P43363 MAGAA			0.527	2
UniProt:Q14686 NCOA6	1	NCOA6 [nucleoplasm] (R-HSA-376414)	0.527	2
UniProt:Q8TB52 FBXO30	1	FBXO30 [cytosol] (R-HSA-8862619)	0.527	3
UniProt:Q9Y6W6 DUSP10	2	DUSP10 [nucleoplasm] (R-HSA-203793) DUSP10 [cytosol] (R-HSA-5675334)	0.527	2
UniProt:Q765P7 MTSS2			0.527	2
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940)	0.527	3
UniProt:Q8TD22 SFXN5			0.527	2
UniProt:P35080 PFN2	1	PFN2 [cytosol] (R-HSA-3009037)	0.527	2
UniProt:P02774 GC	3	GC [lysosomal lumen] (R-HSA-350137) GC [cytosol] (R-HSA-209929) GC [extracellular region] (R-HSA-209886)	0.527	4
UniProt:P10828 THRB	3	polySUMO3-K50,K146,K443-THRB [nucleoplasm] (R-HSA-4719433) monoSUMO1-K50,K146,K443-THRB [nucleoplasm] (R-HSA-4719421) THRB [nucleoplasm] (R-HSA-446179)	0.527	2
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.527	2
UniProt:Q06141 REG3A	3	REG3A(27-37) [extracellular region] (R-HSA-6801783) REG3A(27-175) [extracellular region] (R-HSA-6801803) REG3A(38-175) [extracellular region] (R-HSA-6801352)	0.527	2
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.527	5
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.524	2
UniProt:P83110-2 HTRA3			0.512	3
UniProt:Q9WMX2-PRO_0000037551			0.508	3
UniProt:Q9BSI4 TINF2	1	TINF2 [nucleoplasm] (R-HSA-174883)	0.508	2
IntAct:EBI-6863782 NS3			0.499	2
UniProt:Q92636 NSMAF	1	NSMAF [cytosol] (R-HSA-5626992)	0.499	2
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.491	2
UniProt:P11275 Camk2a	6	phospho-p-T286-CAMK2A [plasma membrane] (R-RNO-432796) phospho-p-T286-CAMK2A [nucleoplasm] (R-RNO-444797) phospho-p-T286,T305,T306-CAMK2A [cytosol] (R-RNO-4332334) phospho-p-T286-CAMK2A [endocytic vesicle membrane] (R-RNO-416999) Camk2a [cytosol] (R-RNO-9611390) p-T286-Camk2a [cytosol] (R-RNO-9618632)	0.488	2
UniProt:Q8TCJ0 FBX25			0.463	2
UniProt:Q8K430 KLH17			0.463	2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2

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