GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2

Stable Identifier
R-HSA-3322009
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
8 UDP-glucose + ((1,4)-alpha-D-glucosyl)4 glycogenin2 => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin2 (GYS2-a)
ReviewStatus
5/5
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Unphosphorylated glycogen synthase 2 (GYS2-a) complexed with oligo-D-glucose-GYG2 catalyzes the polyglucosylation of the latter. (Here the addition of four glucose residues is annotated.) (Orho et al. 1998; Roach et al. 2012).
Literature References
PubMed ID Title Journal Year
9691087 Mutations in the liver glycogen synthase gene in children with hypoglycemia due to glycogen storage disease type 0

Aynsley-Green, A, Orho, M, Gannon, MC, Nuttall, FQ, Blumel, P, Bosshard, NU, Groop, LC, Buist, NR, Gitzelmann, R

J Clin Invest 1998
22248338 Glycogen and its metabolism: some new developments and old themes

Hurley, TD, Roach, PJ, Tagliabracci, VS, DePaoli-Roach, AA

Biochem. J. 2012
Participants
Participates
Catalyst Activity

glycogen (starch) synthase activity of oligoGlc-GYG2:GYS2-a tetramer [cytosol]

Orthologous Events
Reviewed
Created
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