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CDC73 [nucleoplasm]
Stable Identifier
R-HSA-3322360
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Parafibromin, HRPT2
Locations in the PathwayBrowser for interactor UniProt:Q8N7H5 PAF1
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI proteins bind CDC73 (Homo sapiens)
CDC73 [nucleoplasm] (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
Beta-catenin recruits CDC73 and LEO1 (Homo sapiens)
CDC73 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6P1J9 CDC73
Gene Names
CDC73, C1orf28, HRPT2
Chain
initiator methionine:, chain:2-531
Reference Genes
BioGPS Gene:79577 CDC73
COSMIC (genes):CDC73 CDC73
CTD Gene:79577 CDC73
dbSNP Gene:79577 CDC73
ENSEMBL:ENSG00000134371 CDC73
HGNC:16783 CDC73
KEGG:hsa:79577 CDC73
Monarch:79577 CDC73
NCBI Gene:79577 CDC73
OMIM:607393 CDC73
UCSC:Q6P1J9 CDC73
Reference Transcript
RefSeq:NM_024529.4 CDC73
Other Identifiers
11739386_at
11739387_at
11753163_a_at
16675354
218578_PM_at
218578_at
229828_PM_at
229828_at
235196_PM_at
235196_at
2372968
2372969
2372970
2372971
2372974
2372975
2372976
2372977
2372978
2372979
2372980
2372981
2372982
2372983
2372984
2372985
2372986
2372996
2373000
2373001
2373002
2373005
2373006
2373008
2373013
2373014
2373015
2373016
2373017
2373018
2373019
2373020
2373021
2373022
2373023
2373063
44568_at
53141_at
55485_r_at
72467_at
7908437
79577
A_14_P101440
A_14_P106218
A_14_P115098
A_23_P137731
A_24_P285179
A_33_P3219770
GE82850
GE86073
GO:0000122
GO:0000781
GO:0000993
GO:0001558
GO:0001711
GO:0005515
GO:0005634
GO:0005654
GO:0005829
GO:0006355
GO:0006357
GO:0006368
GO:0008285
GO:0016055
GO:0016071
GO:0016593
GO:0019827
GO:0030177
GO:0031124
GO:0031442
GO:0031648
GO:0032968
GO:0043066
GO:0043226
GO:0045638
GO:0045944
GO:0048147
GO:0050680
GO:0071222
GO:1902808
GO:2000134
HMNXSV003043116
Hs.31383.0.A1_3p_at
Hs.95663.0.A1_3p_at
ILMN_1701614
PH_hs_0023303
TC01001626.hg
g13375677_3p_at
Participates
as a component of
CDC73:2p-GLI [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:PAF1-like complex [nucleoplasm] (Homo sapiens)
as an input of
GLI proteins bind CDC73 (Homo sapiens)
Beta-catenin recruits CDC73 and LEO1 (Homo sapiens)
Inferred To
Ghost homologue of CDC73 [nucleoplasm]
(Danio rerio)
cdc73 [nucleoplasm]
(Dictyostelium discoideum)
cdc73 [nucleoplasm]
(Schizosaccharomyces pombe)
cdc73 [nucleoplasm]
(Xenopus tropicalis)
Cdc73 [nucleoplasm]
(Mus musculus)
Cdc73 [nucleoplasm]
(Rattus norvegicus)
cdc-73 [nucleoplasm]
(Caenorhabditis elegans)
hyx [nucleoplasm]
(Drosophila melanogaster)
CDC73 [nucleoplasm]
(Bos taurus)
CDC73 [nucleoplasm]
(Gallus gallus)
CDC73 [nucleoplasm]
(Saccharomyces cerevisiae)
CDC73 [nucleoplasm]
(Sus scrofa)
HRPT2 [nucleoplasm]
(Canis familiaris)
Cross References
RefSeq
NP_078805.3
OpenTargets
ENSG00000134371
ENSEMBL
ENST00000367435
,
ENSP00000356405
HPA
ENSG00000134371-CDC73
PRO
Q6P1J9
Pharos - Targets
Q6P1J9
GlyGen
Q6P1J9
Orphanet
CDC73
HMDB Protein
HMDBP12787
PDB
7UNC
,
5YDF
,
6TED
,
7OPD
,
7UND
,
7OOP
,
7OPC
,
5YDE
Interactors (41)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8N7H5 PAF1
1
PAF1 [nucleoplasm]
(R-HSA-8866689)
0.959
33
UniProt:Q6PD62 CTR9
1
CTR9 [nucleoplasm]
(R-HSA-8866694)
0.938
25
UniProt:Q8WVC0 LEO1
1
LEO1 [nucleoplasm]
(R-HSA-3322361)
0.932
19
UniProt:Q9GZS3 SKIC8
2
WDR61 [cytosol]
(R-HSA-8931534)
WDR61 [nucleoplasm]
(R-HSA-8866696)
0.905
13
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.849
12
UniProt:Q8NHQ1 CEP70
1
CEP70 [cytosol]
(R-HSA-380257)
0.849
10
UniProt:P13196 ALAS1
2
PXLP-ALAS1 [mitochondrial matrix]
(R-HSA-1022086)
ALAS1 [mitochondrial matrix]
(R-HSA-189438)
0.781
9
UniProt:A1L4K1 FSD2
0.781
9
UniProt:Q92541 RTF1
1
RTF1 [nucleoplasm]
(R-HSA-8866693)
0.748
12
UniProt:Q9BZW7 TSG10
0.718
8
UniProt:Q5JR59-3 MTUS2
0.718
6
UniProt:Q8N6L0 KASH5
0.718
6
UniProt:Q12800 TFCP2
0.718
8
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
0.714
10
UniProt:P24928 POLR2A
7
POLR2A [nucleoplasm]
(R-HSA-63502)
p-S2,S5(CTD)-POLR2A [nucleoplasm]
(R-HSA-113420)
p-3S-POLR2A [nucleoplasm]
(R-HSA-6797701)
Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm]
(R-HSA-6781855)
p-S5(CTD)-POLR2A [nucleoplasm]
(R-HSA-77100)
p-S5,S7(CTD)-POLR2A [nucleoplasm]
(R-HSA-6810226)
p-S2,S7(CTD)-POLR2A [nucleoplasm]
(R-HSA-6814543)
0.708
6
UniProt:O75031 HSF2B
0.666
4
UniProt:Q03164 KMT2A
6
KMT2A [cytosol]
(R-HSA-9818584)
KMT2A(2719-3969) [cytosol]
(R-HSA-9818590)
KMT2A(1-2718) [cytosol]
(R-HSA-9818597)
KMT2A [nucleoplasm]
(R-HSA-1183223)
KMT2A(1-2718) [nucleoplasm]
(R-HSA-9818591)
KMT2A(2719-3969) [nucleoplasm]
(R-HSA-9818593)
0.576
4
UniProt:P33240 CSTF2
1
CSTF2 [nucleoplasm]
(R-HSA-72003)
0.576
5
UniProt:O00512 BCL9
1
BCL9 [nucleoplasm]
(R-HSA-201714)
0.564
2
UniProt:Q9H9H4 VPS37B
1
VPS37B [endosome membrane]
(R-HSA-184293)
0.556
3
UniProt:A6NEM1 GG6L9
0.556
3
UniProt:Q5JR59 MTUS2
0.556
5
UniProt:P36406 TRI23
0.556
3
UniProt:Q15276 RABEP1
1
RABEP1 [early endosome membrane]
(R-HSA-2029004)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:Q5VTR2 RNF20
2
RNF20 [cytosol]
(R-HSA-9715141)
RNF20 [nucleoplasm]
(R-HSA-5689011)
0.556
3
UniProt:Q06124-2 PTPN11
0.544
2
UniProt:Q9ERF3
2
Skic8 [nucleoplasm]
(R-MMU-8866696)
Skic8 [cytosol]
(R-MMU-8931534)
0.527
3
UniProt:O00267 SUPT5H
1
p-SUPT5H [nucleoplasm]
(R-HSA-3009372)
0.527
2
UniProt:O00295 TULP2
0.527
3
UniProt:Q15047 SETDB1
1
SETDB1 [nucleoplasm]
(R-HSA-417136)
0.524
3
UniProt:Q96KQ7 EHMT2
1
EHMT2 [nucleoplasm]
(R-HSA-212151)
0.524
3
UniProt:Q12996 CSTF3
1
CSTF3 [nucleoplasm]
(R-HSA-72005)
0.499
4
UniProt:Q10570 CPSF1
1
CPSF1 [nucleoplasm]
(R-HSA-71989)
0.499
4
UniProt:O95639 CPSF4
1
CPSF4 [nucleoplasm]
(R-HSA-169104)
0.499
3
UniProt:Q9P2I0 CPSF2
1
CPSF2 [nucleoplasm]
(R-HSA-71991)
0.499
4
UniProt:O60563 CCNT1
1
CCNT1 [nucleoplasm]
(R-HSA-51611)
0.462
2
UniProt:O75909 CCNK
1
CCNK [nucleoplasm]
(R-HSA-6796619)
0.462
2
IntAct:EBI-2902124 GATA2
0.462
2
IntAct:EBI-2902122 GATA1
0.462
2
UniProt:O94763 RMP
0.462
4
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