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LEO1 [nucleoplasm]
Stable Identifier
R-HSA-3322361
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
RDL
Locations in the PathwayBrowser for interactor UniProt:Q8N7H5 PAF1
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
Beta-catenin recruits CDC73 and LEO1 (Homo sapiens)
LEO1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WVC0 LEO1
Gene Names
LEO1, RDL
Chain
initiator methionine:, chain:2-666
Reference Genes
BioGPS Gene:123169 LEO1
COSMIC (genes):LEO1 LEO1
CTD Gene:123169 LEO1
dbSNP Gene:123169 LEO1
ENSEMBL:ENSG00000166477 LEO1
ENSEMBL_homo_sapiens_GENE:ENSG00000166477.13 LEO1
HGNC:30401 LEO1
KEGG Gene (Homo sapiens):123169 LEO1
Monarch:123169 LEO1
NCBI Gene:123169 LEO1
OMIM:610507 LEO1
UCSC:Q8WVC0 LEO1
Reference Transcript
RefSeq:NM_138792.3 LEO1
RefSeq:NM_001286430.1 LEO1
Other Identifiers
11723233_a_at
123169
16809346
235096_PM_at
235096_at
3624355
3624363
3624364
3624366
3624368
3624369
3624370
3624371
3624372
3624374
3624375
3624377
3624378
3624380
3624381
53272_i_at
53273_r_at
7988838
A_23_P314222
A_33_P3270109
GO:0001650
GO:0001711
GO:0002376
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005813
GO:0005815
GO:0005856
GO:0006351
GO:0006355
GO:0006368
GO:0016055
GO:0016071
GO:0016570
GO:0016593
GO:0019827
GO:0023052
GO:0030154
GO:0031124
GO:0032968
GO:0036211
GO:0043226
GO:0045638
GO:0045944
GO:0048856
GO:1990269
HMNXSV003054848
Hs.296420.0.A1_3p_at
ILMN_1801553
ILMN_1804451
PH_hs_0030230
TC15001449.hg
Participates
as a component of
PAF1C [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:PAF1-like complex [nucleoplasm] (Homo sapiens)
as an input of
Beta-catenin recruits CDC73 and LEO1 (Homo sapiens)
Inferred To
Atu [nucleoplasm]
(Drosophila melanogaster)
leo-1 [nucleoplasm]
(Caenorhabditis elegans)
Leo1 [nucleoplasm]
(Mus musculus)
Leo1 [nucleoplasm]
(Rattus norvegicus)
leo1 [nucleoplasm]
(Danio rerio)
leo1 [nucleoplasm]
(Dictyostelium discoideum)
leo1 [nucleoplasm]
(Xenopus tropicalis)
LEO1 [nucleoplasm]
(Bos taurus)
LEO1 [nucleoplasm]
(Canis familiaris)
LEO1 [nucleoplasm]
(Gallus gallus)
LEO1 [nucleoplasm]
(Saccharomyces cerevisiae)
LEO1 [nucleoplasm]
(Schizosaccharomyces pombe)
LEO1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001273359.1
,
NP_620147.1
OpenTargets
ENSG00000166477
HPA
ENSG00000166477-LEO1
GeneCards
Q8WVC0
Ensembl
ENSP00000299601
,
ENST00000299601
,
ENSP00000314610
,
ENST00000315141
,
ENSG00000166477
PRO
Q8WVC0
Pharos - Targets
Q8WVC0
PDB
7OPD
,
7OOP
,
6TED
,
6GMH
,
7UNC
,
7UND
,
4M6T
,
7OPC
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8N7H5 PAF1
1
PAF1 [nucleoplasm]
(R-HSA-8866689)
0.949
30
UniProt:Q6P1J9 CDC73
1
CDC73 [nucleoplasm]
(R-HSA-3322360)
0.932
19
UniProt:Q6PD62 CTR9
1
CTR9 [nucleoplasm]
(R-HSA-8866694)
0.789
15
UniProt:Q9GZS3 SKIC8
2
WDR61 [cytosol]
(R-HSA-8931534)
WDR61 [nucleoplasm]
(R-HSA-8866696)
0.725
7
UniProt:P23193 TCEA1
1
TCEA1 [nucleoplasm]
(R-HSA-65748)
0.577
4
UniProt:O75764 TCEA3
0.556
3
UniProt:Q6PI77 GASP3
0.556
3
UniProt:Q92541 RTF1
1
RTF1 [nucleoplasm]
(R-HSA-8866693)
0.527
5
UniProt:O00267 SUPT5H
1
p-SUPT5H [nucleoplasm]
(R-HSA-3009372)
0.527
3
UniProt:Q14241 ELOA
1
TCEB3 [nucleoplasm]
(R-HSA-112421)
0.508
2
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