Beta-catenin recruits SMARCA4

Stable Identifier
R-HSA-3322422
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SMARCA4, one of two ATPase components of SWI/SNF chromatin remodelling complexes, was identified in a two-hybrid screen for beta-catenin interactors that activate TCF/LEF-dependent transcription (Barker et al, 2001; Wilson and Roberts, 2011). SMARCA4 co-immunoprecipitates with beta-catenin when both tagged proteins are expressed in HEK293 cells; likewise, tagged SMARCA4 co-precipitates endogenous beta-catenin from a colon carcinoma cell line. Expression of SMARCA4 enhances the expression of a TCF reporter in a manner that depends on a functional ATPase domain, indicating a probable role for chromatin remodelling at WNT-responsive promoters (Barker et al, 2001). By ChIP, SMARCA4 and beta-catenin are associated with WNT-responsive promoters upon WNT pathway stimulation; this study also identified TERT, a telomerase reverse transcriptase, as SMARCA4-interacting protein that is present at WNT promoters (Park et al, 2009).
Literature References
PubMed ID Title Journal Year
11532957 The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation

Barker, N, Clevers, HC, Musisi, H, Bienz, M, Miles, A, Hurlstone, A

EMBO J. 2001
19571879 Telomerase modulates Wnt signalling by association with target gene chromatin

Venteicher, AS, Park, JI, Jun, S, Artandi, SE, Nusse, R, Ji, H, Cheung, P, Veenstra, TD, Shkreli, M, Meng, Z, Choi, J, McLaughlin, M, Chang, W, Hong, JY, McCrea, PD

Nature 2009
21654818 SWI/SNF nucleosome remodellers and cancer

Roberts, CW, Wilson, BG

Nat. Rev. Cancer 2011
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!