GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

Stable Identifier
R-HSA-3323013
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Glutathione peroxidase 1 (GPX1) located in the mitochondrial matrix (Bera et al. 2014) uses glutathione to reduce hydrogen peroxide (H2O2) to yield oxidized glutathione and water (Legault et al. 2000, Li et al. 2000, Faucher et al. 2003, Lu et al. 2012). As inferred from rat mitochondria, GPX1 is the major determinant of steady-state hydrogen peroxide levels (Antunes et al. 2002).

Literature References
PubMed ID Title Journal Year
10833429 Mitochondrial GPx1 decreases induced but not basal oxidative damage to mtDNA in T47D cells

Legault, J, Carrier, C, Petrov, P, Renard, P, Remacle, J, Mirault, ME

Biochem. Biophys. Res. Commun. 2000
25047527 Natural allelic variations in glutathione peroxidase-1 affect its subcellular localization and function

Bera, S, Weinberg, F, Ekoue, DN, Ansenberger-Fricano, K, Mao, M, Bonini, MG, Diamond, AM

Cancer Res 2014
23152058 ZNF143 transcription factor mediates cell survival through upregulation of the GPX1 activity in the mitochondrial respiratory dysfunction

Lu, W, Chen, Z, Zhang, H, Wang, Y, Luo, Y, Huang, P

Cell Death Dis 2012
10919671 The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase

Li, S, Yan, T, Yang, JQ, Oberley, TD, Oberley, LW

Cancer Res. 2000
12829378 Overexpression of cytosolic glutathione peroxidase (GPX1) delays endothelial cell growth and increases resistance to toxic challenges

Faucher, K, Rabinovitch-Chable, H, Barrière, G, Cook-Moreau, J, Rigaud, M

Biochimie 2003
Participants
Participates
Catalyst Activity

glutathione peroxidase activity of GPX1 tetramer [mitochondrial matrix]

Orthologous Events
Authored
Reviewed
Created
Cite Us!