GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

Stable Identifier
Reaction [transition]
Homo sapiens
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Glutathione peroxidase 1 (GPX1) located in the mitochondrial matrix (Bera et al. 2014) uses glutathione to reduce hydrogen peroxide (H2O2) to yield oxidized glutathione and water (Legault et al. 2000, Li et al. 2000, Faucher et al. 2003, Lu et al. 2012). As inferred from rat mitochondria, GPX1 is the major determinant of steady-state hydrogen peroxide levels (Antunes et al. 2002).
Literature References
PubMed ID Title Journal Year
25047527 Natural allelic variations in glutathione peroxidase-1 affect its subcellular localization and function

Bonini, MG, Weinberg, F, Mao, M, Diamond, AM, Ekoue, DN, Bera, S, Ansenberger-Fricano, K

Cancer Res 2014
10833429 Mitochondrial GPx1 decreases induced but not basal oxidative damage to mtDNA in T47D cells

Mirault, ME, Petrov, P, Carrier, C, Legault, J, Renard, P, Remacle, J

Biochem. Biophys. Res. Commun. 2000
23152058 ZNF143 transcription factor mediates cell survival through upregulation of the GPX1 activity in the mitochondrial respiratory dysfunction

Luo, Y, Huang, P, Chen, Z, Lu, W, Zhang, H, Wang, Y

Cell Death Dis 2012
10919671 The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase

Yang, JQ, Li, S, Yan, T, Oberley, LW, Oberley, TD

Cancer Res. 2000
12829378 Overexpression of cytosolic glutathione peroxidase (GPX1) delays endothelial cell growth and increases resistance to toxic challenges

Barrière, G, Cook-Moreau, J, Faucher, K, Rigaud, M, Rabinovitch-Chable, H

Biochimie 2003
Catalyst Activity

glutathione peroxidase activity of GPX1 tetramer [mitochondrial matrix]

Orthologous Events
Cross References
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