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PRDX1 [cytosol]
Stable Identifier
R-HSA-3341270
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Peroxiredoxin-1 ecNumber1.11.1.15/ecNumber, PRDX1_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Homo sapiens)
PRDX1,2,5 [cytosol] (Homo sapiens)
PRDX1 dimer [cytosol] (Homo sapiens)
PRDX1 [cytosol] (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Homo sapiens)
NFE2L2-dependent PRDX1 gene expression (Homo sapiens)
PRDX1 dimer [cytosol] (Homo sapiens)
PRDX1 [cytosol] (Homo sapiens)
PRDX1 overoxidizes (Homo sapiens)
HOOS-C52-PRDX1 dimer [cytosol] (Homo sapiens)
PRDX1 [cytosol] (Homo sapiens)
PRDX1 [cytosol] (Homo sapiens)
PRDX1 dimer [cytosol] (Homo sapiens)
PRDX1 [cytosol] (Homo sapiens)
SRXN1 reduces hyperoxidized PRDX1 dimer (Homo sapiens)
HOOS-C52-PRDX1 dimer [cytosol] (Homo sapiens)
PRDX1 [cytosol] (Homo sapiens)
PRDX1 dimer [cytosol] (Homo sapiens)
PRDX1 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
Neurodegenerative Diseases (Homo sapiens)
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
CDK5:p25 phosphorylates PRDX1 (Homo sapiens)
PRDX1 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
PRDX1 overoxidizes (Homo sapiens)
HOOS-C52-PRDX1 dimer [cytosol] (Homo sapiens)
PRDX1 [cytosol] (Homo sapiens)
PRDX1 [cytosol] (Homo sapiens)
PRDX1 dimer [cytosol] (Homo sapiens)
PRDX1 [cytosol] (Homo sapiens)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Homo sapiens)
PRDX1,2,5 [cytosol] (Homo sapiens)
PRDX1 dimer [cytosol] (Homo sapiens)
PRDX1 [cytosol] (Homo sapiens)
SESN1,2,3 bind overoxidized PRDX1 (Homo sapiens)
HOOS-C52-PRDX1 dimer [cytosol] (Homo sapiens)
PRDX1 [cytosol] (Homo sapiens)
SESN1,2,3:HOOS-C52-PRDX1 dimer [cytosol] (Homo sapiens)
HOOS-C52-PRDX1 dimer [cytosol] (Homo sapiens)
PRDX1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q06830 PRDX1
Gene Names
PRDX1, PAGA, PAGB, TDPX2
Chain
initiator methionine:, chain:2-199
Reference Genes
BioGPS Gene:5052 PRDX1
COSMIC (genes):PRDX1 PRDX1
CTD Gene:5052 PRDX1
dbSNP Gene:5052 PRDX1
ENSEMBL:ENSG00000117450 PRDX1
HGNC:9352 PRDX1
KEGG:hsa:5052 PRDX1
Monarch:5052 PRDX1
NCBI Gene:5052 PRDX1
OMIM:176763 PRDX1
UCSC:Q06830 PRDX1
Reference Transcript
RefSeq:NM_181697.2 PRDX1
RefSeq:NM_002574.3 PRDX1
RefSeq:NM_001202431.1 PRDX1
RefSeq:NM_181696.2 PRDX1
Other Identifiers
11742924_a_at
16686472
208680_PM_at
208680_at
2410243
2410244
2410245
2410246
2410247
2410248
2410249
2410250
2410252
2410253
2410254
3198940
41213_at
5052
7915733
A_23_P11995
A_33_P3377199
GE62148
GO:0000302
GO:0001501
GO:0002376
GO:0003723
GO:0003824
GO:0004601
GO:0005515
GO:0005615
GO:0005634
GO:0005737
GO:0005829
GO:0006979
GO:0007249
GO:0008283
GO:0008379
GO:0016209
GO:0016491
GO:0019430
GO:0030101
GO:0031410
GO:0032872
GO:0034101
GO:0042267
GO:0042470
GO:0042744
GO:0042802
GO:0043226
GO:0045296
GO:0045321
GO:0045454
GO:0048144
GO:0048856
GO:0051920
GO:0070062
GO:0098542
GO:0098754
GO:0098869
GO:0140824
GO:1901222
HMNXSV003001899
ILMN_2366388
ILMN_2366391
PH_hs_0029347
TC01002611.hg
X67951_at
g440305_3p_s_at
Participates
as an input of
CDK5:p25 phosphorylates PRDX1 (Homo sapiens)
as a component of
HOOS-C52-PRDX1 dimer [cytosol] (Homo sapiens)
PRDX1 dimer [cytosol] (Homo sapiens)
Other forms of this molecule
HOOS-C52-PRDX1 [cytosol]
p-T90-PRDX1 [cytosol]
Inferred To
Prx2 [cytosol]
(Drosophila melanogaster)
prdx-2 [cytosol]
(Caenorhabditis elegans)
prdx4 [cytosol]
(Dictyostelium discoideum)
tpx1 [cytosol]
(Schizosaccharomyces pombe)
PRDX1 [cytosol]
(Bos taurus)
PRDX1 [cytosol]
(Canis familiaris)
PRDX1 [cytosol]
(Gallus gallus)
PRDX1 [cytosol]
(Saccharomyces cerevisiae)
PRDX1 [cytosol]
(Sus scrofa)
prdx1 [cytosol]
(Danio rerio)
prdx1 [cytosol]
(Xenopus tropicalis)
Prdx1 [cytosol]
(Mus musculus)
Prdx1 [cytosol]
(Rattus norvegicus)
Cross References
OpenTargets
ENSG00000117450
ENSEMBL
ENSP00000262746
,
ENSP00000503140
,
ENSP00000389047
,
ENSP00000361152
,
ENST00000676549
,
ENST00000447184
,
ENSP00000407034
,
ENST00000424390
,
ENST00000319248
,
ENST00000262746
IntEnz
1.11.1.24
HPA
ENSG00000117450-PRDX1
PRO
Q06830
Pharos - Targets
Q06830
GlyGen
Q06830
HMDB Protein
HMDBP02990
PDB
4XCS
,
7LJ1
,
8X73
,
7WET
,
2RII
,
7WEU
,
3HY2
,
8X71
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.706
21
UniProt:Q13043 STK4
4
STK4(1-487) [cytosol]
(R-HSA-201627)
STK4(327-487) [cytosol]
(R-HSA-2028668)
p-T183-STK4(1-487) [cytosol]
(R-HSA-2028258)
p-T183-STK4(1-326) [cytosol]
(R-HSA-2028682)
0.66
11
UniProt:P60484 PTEN
20
K48polyUb-PTEN [cytosol]
(R-HSA-8874327)
PolyUb-PTEN [nucleoplasm]
(R-HSA-6782515)
PTEN H93R [cytosol]
(R-HSA-2318524)
PTEN C124R [cytosol]
(R-HSA-2317439)
PTEN H93Y [cytosol]
(R-HSA-2318520)
PTEN R130G [cytosol]
(R-HSA-2317339)
PTEN H93D [cytosol]
(R-HSA-2318550)
PTEN R130L [cytosol]
(R-HSA-2317430)
PTEN H93A [cytosol]
(R-HSA-2318544)
PTEN G129E [cytosol]
(R-HSA-2318509)
PTEN S170N [cytosol]
(R-HSA-2318408)
PTEN R173P [cytosol]
(R-HSA-2317480)
PTEN R130Q [cytosol]
(R-HSA-2317416)
PTEN H93Q [cytosol]
(R-HSA-2318565)
PTEN G129R [cytosol]
(R-HSA-2318501)
PTEN H123Y [cytosol]
(R-HSA-2318469)
PTEN S170R [cytosol]
(R-HSA-2318437)
PTEN R173C [cytosol]
(R-HSA-2317478)
PTEN R173H [cytosol]
(R-HSA-2317473)
PTEN C124S [cytosol]
(R-HSA-2317379)
0.632
7
UniProt:Q9BYN0 SRXN1
1
SRXN1 [endoplasmic reticulum membrane]
(R-HSA-9759366)
0.618
3
UniProt:Q13162 PRDX4
3
PRDX4 [ficolin-1-rich granule lumen]
(R-HSA-6803286)
PRDX4 [extracellular region]
(R-HSA-6806512)
PRDX4 [secretory granule lumen]
(R-HSA-6803305)
0.573
2
UniProt:P13693 TCTP
0.567
4
UniProt:Q86TI2-2 Q86TI22
0.556
3
UniProt:Q8N7X4 MAGB6
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:P10275 AR
4
AR [cytosol]
(R-HSA-5618082)
AR [nucleoplasm]
(R-HSA-446174)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
0.544
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
4
UniProt:P54274 TERF1
1
TERF1 [nucleoplasm]
(R-HSA-164618)
0.508
2
UniProt:P04156 PRNP
2
PRNP [cytosol]
(R-HSA-9617597)
PRNP [plasma membrane]
(R-HSA-375060)
0.499
4
UniProt:Q00005 2ABB
0.462
2
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