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PRDX2 [cytosol]
Stable Identifier
R-HSA-3341292
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Peroxiredoxin-2 ecNumber1.11.1.15/ecNumber, PRDX2_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Homo sapiens)
PRDX1,2,5 [cytosol] (Homo sapiens)
PRDX2 dimer [cytosol] (Homo sapiens)
PRDX2 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
Neurodegenerative Diseases (Homo sapiens)
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
CDK5:p25 phosphorylates PRDX2 (Homo sapiens)
PRDX2 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Homo sapiens)
PRDX1,2,5 [cytosol] (Homo sapiens)
PRDX2 dimer [cytosol] (Homo sapiens)
PRDX2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P32119 PRDX2
Gene Names
PRDX2, NKEFB, TDPX1
Chain
initiator methionine:, chain:2-198
Reference Genes
BioGPS Gene:7001 PRDX2
COSMIC (genes):PRDX2 PRDX2
CTD Gene:7001 PRDX2
dbSNP Gene:7001 PRDX2
ENSEMBL:ENSG00000167815 PRDX2
ENSEMBL_homo_sapiens_GENE:ENSG00000167815.12 PRDX2
HGNC:9353 PRDX2
KEGG Gene (Homo sapiens):7001 PRDX2
Monarch:7001 PRDX2
NCBI Gene:7001 PRDX2
OMIM:600538 PRDX2
Reference Transcript
RefSeq:NM_005809.5 PRDX2
Other Identifiers
11715409_a_at
11715410_x_at
11741148_a_at
11745462_a_at
11745463_x_at
16869324
2918798
3483891
3851778
3851779
3851780
3851784
3851787
3851795
3851796
3851798
39729_3p_at
39729_PM_at
39729_at
4882231C_3p_x_at
7001
A_23_P142045
A_24_P168416
GE57657
GO:0002357
GO:0002376
GO:0002536
GO:0003824
GO:0004601
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005829
GO:0006954
GO:0006979
GO:0007155
GO:0008379
GO:0010310
GO:0012501
GO:0016209
GO:0016491
GO:0019430
GO:0023052
GO:0030154
GO:0030194
GO:0031665
GO:0032496
GO:0034599
GO:0042060
GO:0042098
GO:0042743
GO:0042744
GO:0042981
GO:0043029
GO:0043066
GO:0043226
GO:0043410
GO:0045321
GO:0045454
GO:0045581
GO:0048538
GO:0048856
GO:0050896
GO:0051920
GO:0070062
GO:0097191
GO:0098754
GO:0140824
GO:2001237
GO:2001240
PH_hs_0030160
PH_hs_0035955
TC19001210.hg
Z22548_at
g440307_3p_s_at
Participates
as an input of
CDK5:p25 phosphorylates PRDX2 (Homo sapiens)
as a component of
PRDX2 dimer [cytosol] (Homo sapiens)
Other forms of this molecule
p-T89-PRDX2 [cytosol]
Inferred To
Prx2 [cytosol]
(Drosophila melanogaster)
prdx-2 [cytosol]
(Caenorhabditis elegans)
prdx4 [cytosol]
(Dictyostelium discoideum)
PRDX2 [cytosol]
(Bos taurus)
PRDX2 [cytosol]
(Canis familiaris)
PRDX2 [cytosol]
(Saccharomyces cerevisiae)
PRDX2 [cytosol]
(Sus scrofa)
tpx1 [cytosol]
(Schizosaccharomyces pombe)
Prdx2 [cytosol]
(Mus musculus)
Prdx2 [cytosol]
(Rattus norvegicus)
prdx2 [cytosol]
(Danio rerio)
TSA2 [cytosol]
(Saccharomyces cerevisiae)
Homologues of PRDX2 [cytosol]
(Drosophila melanogaster)
Homologues of PRDX2 [cytosol]
(Saccharomyces cerevisiae)
Prx1 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_005800.3
OpenTargets
ENSG00000167815
HPA
ENSG00000167815-PRDX2
GeneCards
P32119
Ensembl
ENSP00000301522
,
ENSG00000167815
,
ENST00000301522
PRO
P32119
Pharos - Targets
P32119
HMDB Protein
HMDBP03017
PDB
7KIZ
,
1QMV
,
5B8B
,
7KJ0
,
5B8A
,
5IJT
,
7KJ1
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.706
22
UniProt:P10599 TXN
4
2xHC-TXN [nucleoplasm]
(R-HSA-9617733)
TXN [nucleoplasm]
(R-HSA-9617732)
2xHC-TXN [cytosol]
(R-HSA-73668)
TXN [cytosol]
(R-HSA-66000)
0.564
2
UniProt:Q05707 COL14A1
20
GlcGalHyl-COL14A1 [endoplasmic reticulum lumen]
(R-HSA-2173131)
3x4Hyp-3Hyp-GlcGalHyl-COL14A1 [endoplasmic reticulum lumen]
(R-HSA-2173275)
3x4Hyp-GalHyl-COL14A1 [endoplasmic reticulum lumen]
(R-HSA-2173174)
3x4Hyp-3Hyp-GalHyl-COL14A1 [endoplasmic reticulum lumen]
(R-HSA-2173253)
3x4Hyp-GlcGalHyl-COL14A1 [endoplasmic reticulum lumen]
(R-HSA-2173203)
GalHyl-COL14A1 [endoplasmic reticulum lumen]
(R-HSA-2173088)
COL14A1 [endoplasmic reticulum lumen]
(R-HSA-2172297)
3x4Hyp-COL14A1 [endoplasmic reticulum lumen]
(R-HSA-2172941)
3x4Hyp-3Hyp-COL14A1 [endoplasmic reticulum lumen]
(R-HSA-2172965)
3x4Hyp-5Hyl-COL14A1 [endoplasmic reticulum lumen]
(R-HSA-2173151)
3x4Hyp-3Hyp-5Hyl-COL14A1 [endoplasmic reticulum lumen]
(R-HSA-2173216)
5Hyl-COL14A1 [endoplasmic reticulum lumen]
(R-HSA-2173048)
3x4Hyp-3Hyp-GlcGalHyl-COL14A1(29-?) [extracellular region]
(R-HSA-2470778)
3x4Hyp-COL14A1(?-1796) [extracellular region]
(R-HSA-2470779)
3x4Hyp-3Hyp-GlcGalHyl-COL14A1(?-1796) [extracellular region]
(R-HSA-2470777)
COL14A1(?-1796) [extracellular region]
(R-HSA-2470782)
5Hyl-COL14A1(29-?) [extracellular region]
(R-HSA-2470783)
GlcGalHyl-COL14A1(?-1796) [extracellular region]
(R-HSA-2470780)
GlcGalHyl-COL14A1(29-?) [extracellular region]
(R-HSA-2470781)
3x4Hyp-5Hyl-COL14A1(29-?) [extracellular region]
(R-HSA-2470771)
0.508
2
UniProt:Q8NET4 RTL9
0.508
2
UniProt:Q9NXV2 KCTD5
0.508
2
UniProt:P30048 PRDX3
1
PRDX3 [mitochondrial matrix]
(R-HSA-3323081)
0.508
2
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.499
4
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