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L-selenoC73-GPX3 [extracellular region]
Stable Identifier
R-HSA-3341324
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
GPX3, Glutathione peroxidase 3, GPX3_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)
GPX3 tetramer [extracellular region] (Homo sapiens)
L-selenoC73-GPX3 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22352 GPX3
Gene Names
GPX3, GPXP
Chain
signal peptide:1-20, chain:21-226
Reference Genes
BioGPS Gene:2878 GPX3
COSMIC (genes):GPX3 GPX3
CTD Gene:2878 GPX3
dbSNP Gene:2878 GPX3
ENSEMBL:ENSG00000211445 GPX3
ENSEMBL_homo_sapiens_GENE:ENSG00000211445.13 GPX3
HGNC:4555 GPX3
KEGG Gene (Homo sapiens):2878 GPX3
Monarch:2878 GPX3
NCBI Gene:2878 GPX3
OMIM:138321 GPX3
UCSC:P22352 GPX3
Reference Transcript
RefSeq:NM_002084.4 GPX3
RefSeq:NM_001329790.1 GPX3
Other Identifiers
11730170_a_at
11757266_s_at
16991192
201348_PM_at
201348_at
214091_PM_s_at
214091_s_at
2835718
2835719
2835728
2835736
2835739
2835740
2835741
2835742
2835743
2835744
2835745
2835746
2878
770_at
8109333
A_23_P133474
A_33_P3369371
D00632_at
GE81112
GO:0003824
GO:0004601
GO:0004602
GO:0005515
GO:0005576
GO:0005615
GO:0006979
GO:0006982
GO:0008430
GO:0016209
GO:0016491
GO:0042744
GO:0042802
GO:0043226
GO:0070062
GO:0098754
GO:0098869
ILMN_1726666
PH_hs_0009848
PH_hs_0018794
TC05000837.hg
TC05002693.hg
g6006000_3p_a_at
Participates
as a component of
GPX3 tetramer [extracellular region] (Homo sapiens)
Inferred To
Homologues of L-selenoC73-GPX3 [extracellular region]
(Caenorhabditis elegans)
GPX3 [extracellular region]
(Bos taurus)
GPX3 [extracellular region]
(Sus scrofa)
gpx-5 [extracellular region]
(Caenorhabditis elegans)
gpx-3 [extracellular region]
(Caenorhabditis elegans)
L-selenoC73-GPX3 [extracellular region]
(Gallus gallus)
Gpx3 [extracellular region]
(Mus musculus)
Gpx3 [extracellular region]
(Rattus norvegicus)
Modified Residues
Name
L-selenocysteine residue at 73
Coordinate
73
PsiMod Name
L-selenocysteine residue
PsiMod Definition
A protein modification that effectively converts a source amino acid residue to an L-selenocysteine, a natural pretranslational modification.
Cross References
RefSeq
NP_001316719.1
,
NP_002075.2
OpenTargets
ENSG00000211445
HPA
ENSG00000211445-GPX3
GeneCards
P22352
Ensembl
ENSP00000373477
,
ENSG00000211445
,
ENST00000388825
PRO
P22352
Pharos - Targets
P22352
HMDB Protein
HMDBP00830
PDB
2R37
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