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Recruitment of SET1 methyltransferase complex
Stable Identifier
R-HSA-3364014
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
Recruitment of SET1 methyltransferase complex (Homo sapiens)
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A number of SET1-type complex proteins are pulled down from HeLa and SW480 extracts by a fragment of beta-catenin consisting of ARM repeats 11 and 12 and the adjacent C-terminal activation domain (Sierra et al, 2006). SET1 complexes are histone methyltransferases that promote H3K4 trimethylation in a manner that depends on prior ubiquitination of H2B; H3K4 is a mark associated with active chromatin (reviewed in Shilatifard, 2006). ChIP experiments show that SET1 complex members MLL2, MEN1, RBBP5 and ASH2L cycle on and off the MYC promoter in vivo in a complex with BCL9, PYGO and beta-catenin. Recruitment of the SET proteins correlates with increased H3K4me3 and transcription of the MYC gene, and endogenous mMYC mRNA levels decline somewhat in the presence of MLL2 siRNA. These data suggest that the C-terminal of beta-catenin interacts with a functional histone H3 methyltransferase complex that activates WNT-target gene transcription (Sierra et al, 2006).
Literature References
PubMed ID
Title
Journal
Year
16510874
The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes
Yoshida, T
,
Jones, KA
,
Sierra, J
,
Joazeiro, CA
Genes Dev.
2006
16756492
Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression
Shilatifard, A
Annu. Rev. Biochem.
2006
Participants
Input
ASH2L [nucleoplasm]
(Homo sapiens)
KMT2D [nucleoplasm]
(Homo sapiens)
MEN1 [nucleoplasm]
(Homo sapiens)
RBBP5 [nucleoplasm]
(Homo sapiens)
TCF/LEF:CTNNB1:BCL9:PYGO [nucleoplasm]
(Homo sapiens)
Output
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
Orthologous Events
Recruitment of SET1 methyltransferase complex (Bos taurus)
Recruitment of SET1 methyltransferase complex (Canis familiaris)
Recruitment of SET1 methyltransferase complex (Drosophila melanogaster)
Recruitment of SET1 methyltransferase complex (Mus musculus)
Authored
Rothfels, K (2013-05-30)
Reviewed
Rajakulendran, N (2014-01-22)
van Amerongen, R (2014-02-15)
Kikuchi, A (2014-04-22)
Created
Rothfels, K (2013-05-13)
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