Reactome | Ub-121-HIST1H2BK [nucleoplasm]

Ub-121-HIST1H2BK [nucleoplasm]

Stable Identifier

R-HSA-3364019

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone H2B K K121ub

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by WNT (Homo sapiens)
  - TCF dependent signaling in response to WNT (Homo sapiens)
    - Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
      - SET1 complex trimethylates H3K4 at the MYC gene (Homo sapiens)
        
        MYC gene: H2B K121ub nucleosome [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H2BK121ub [nucleoplasm] (Homo sapiens)
        
        Histone H2B K121ub [nucleoplasm] (Homo sapiens)
        
        Ub-121-HIST1H2BK [nucleoplasm] (Homo sapiens)
        
        MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H2BK121ub and H3K4me3 [nucleoplasm] (Homo sapiens)
        
        Histone H2B K121ub [nucleoplasm] (Homo sapiens)
        
        Ub-121-HIST1H2BK [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60814 H2BC12

Gene Names

H2BC12, H2BFT, HIRIP1, HIST1H2BK

Chain

initiator methionine:, chain:2-126

Reference Genes

BioGPS Gene:85236 H2BC12

COSMIC (genes):HIST1H2BK H2BC12

CTD Gene:85236 H2BC12

dbSNP Gene:85236 H2BC12

ENSEMBL:ENSG00000197903 HIST1H2BK

HGNC:13954 H2BC12

KEGG:hsa:85236 H2BC12

Monarch:85236 H2BC12

NCBI Gene:85236 H2BC12

OMIM:615045 H2BC12

UCSC:O60814 H2BC12

Reference Transcript

Other Identifiers

11717099_at

17016457

208579_PM_x_at

208579_x_at

209806_PM_at

209806_at

2946715

2946716

2946717

2946721

2946722

32819_at

35576_f_at

36347_f_at

3923212

3923213

8068898

8124492

85236

A_23_P145238

A_33_P3229083

GE553273

GE577410

GO:0000786

GO:0002227

GO:0002376

GO:0003674

GO:0003677

GO:0005198

GO:0005515

GO:0005615

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0019731

GO:0030527

GO:0031640

GO:0042742

GO:0043226

GO:0043229

GO:0046982

GO:0050829

GO:0050830

GO:0061844

GO:0098542

HMNXSV003040333

ILMN_1796179

ILMN_1813314

PH_hs_0013112

PH_hs_0037388

TC06001387.hg

TC06001388.hg

TC21000211.hg

TC21000762.hg

g12654150_3p_at

Participates

as a candidate of

Histone H2B K121ub [nucleoplasm] (Homo sapiens)

Other forms of this molecule

HIST1H2BK [nucleoplasm]

AcK21-HIST1H2BK [nucleoplasm]

AcK13-HIST1H2BK [nucleoplasm]

AcK16-HIST1H2BK [nucleoplasm]

AcK6-HIST1H2BK [nucleoplasm]

HIST1H2BK [extracellular region]

AcK-HIST1H2BK [nucleoplasm]

Ub-HIST1H2BK [nucleoplasm]

Inferred To

H2Bv1 [nucleoplasm] (Dictyostelium discoideum)

H2B-VIII [nucleoplasm] (Gallus gallus)

His2B [nucleoplasm] (Drosophila melanogaster)

H2AC12 [nucleoplasm] (Bos taurus)

H2Bv2 [nucleoplasm] (Dictyostelium discoideum)

htb1 [nucleoplasm] (Schizosaccharomyces pombe)

Ub-121-HIST1H2BK [nucleoplasm] (Danio rerio)

Ub-121-HIST1H2BK [nucleoplasm] (Plasmodium falciparum)

h2bc11 [nucleoplasm] (Xenopus tropicalis)

HIST1H2B5L [nucleoplasm] (Gallus gallus)

H2B-V [nucleoplasm] (Gallus gallus)

si:ch211-113a14.22 [nucleoplasm] (Danio rerio)

LOC100498553 [nucleoplasm] (Xenopus tropicalis)

LOC116411635 [nucleoplasm] (Xenopus tropicalis)

H2Bv3 [nucleoplasm] (Dictyostelium discoideum)

H2B-VII [nucleoplasm] (Gallus gallus)

Homologues of Ub-121-HIST1H2BK [nucleoplasm] (Danio rerio)

Homologues of Ub-121-HIST1H2BK [nucleoplasm] (Dictyostelium discoideum)

Homologues of Ub-121-HIST1H2BK [nucleoplasm] (Gallus gallus)

Homologues of Ub-121-HIST1H2BK [nucleoplasm] (Plasmodium falciparum)

Homologues of Ub-121-HIST1H2BK [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of Ub-121-HIST1H2BK [nucleoplasm] (Xenopus tropicalis)

H2B-I [nucleoplasm] (Gallus gallus)

hist2h2l [nucleoplasm] (Danio rerio)

HTB1 [nucleoplasm] (Saccharomyces cerevisiae)

LOC570661 [nucleoplasm] (Danio rerio)

HTB2 [nucleoplasm] (Saccharomyces cerevisiae)

h2bc21 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

ubiquitinylated lysine at 121

Coordinate

121

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_542160.1, NP_001299582.1

OpenTargets

ENSG00000197903

ENSEMBL

ENSP00000349430, ENST00000356950, ENSG00000197903

HPA

ENSG00000197903-H2BC12

GeneCards

H2BC12

PRO

O60814

Pharos - Targets

O60814

GlyGen

O60814

PDB

6T7B, 7XCR, 8HQY, 8Q3X, 7XD1, 6LE9, 7PEU, 7PFC, 7PEX, 7PFD, 7DBP, 7PF3, 6V92, 7PEY, 6T7C, 7JZV, 6T7D, 7V9C, 8Q3M, 6T7A, 7PFW, 8X7I, 7PFU, 8JHG, 8YV8, 7PFE, 8WG5, 7PF5, 7PEW, 7BWD, 2CV5, 7PFF, 7V96, 8W9E, 8JHF, 8W9D, 8X7J, 6T79, 8W9F, 7XCT, 7V90, 8Q36, 9IPU, 8IEJ, 7PF6, 7PF0, 7PF4, 7PF2, 7PFA, 7PEZ, 7V9J, 8Q3E, 7V9K, 7VA4, 7V9S, 6L9H, 7PFX, 7PFT, 7PFV, 6KE9, 8IEG, 7PET, 7PEV, 7V99, 8HR1, 6Y5D, 8X7K, 8GRQ

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.576	5

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