Reactome | DNAJA1 [cytosol]

DNAJA1 [cytosol]

Stable Identifier

R-HSA-3371544

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

DnaJ homolog subfamily A member 1, DnaJ protein homolog 2, HSDJ, Heat shock 40 kDa protein 4

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External Reference Information

External Reference

UniProt:P31689 DNAJA1

Gene Names

DNAJA1, DNAJ2, HDJ2, HSJ2, HSPF4

Chain

chain:1-394, propeptide:395-397

Reference Genes

BioGPS Gene:3301 DNAJA1

COSMIC (genes):DNAJA1 DNAJA1

CTD Gene:3301 DNAJA1

dbSNP Gene:3301 DNAJA1

ENSEMBL:ENSG00000086061 DNAJA1

HGNC:5229 DNAJA1

KEGG:hsa:3301 DNAJA1

Monarch:3301 DNAJA1

NCBI Gene:3301 DNAJA1

OMIM:602837 DNAJA1

UCSC:P31689 DNAJA1

Reference Transcript

RefSeq:NM_001539.3 DNAJA1

Other Identifiers

11717188_s_at

11717189_x_at

11760005_x_at

11761703_s_at

11764037_s_at

17084237

200880_PM_at

200880_at

200881_PM_s_at

200881_s_at

2566258

276_at

3166717

3166719

3166720

3166721

3166722

3166725

3166726

3166727

3166728

3166729

3166731

3166732

3166733

3166734

3166735

3166736

3301

39118_at

4017318

8154765

A_14_P106115

A_23_P60479

A_24_P192586

A_24_P9671

GE79841

GE85825

GO:0001664

GO:0001671

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005739

GO:0005783

GO:0005829

GO:0005856

GO:0006457

GO:0006986

GO:0007018

GO:0007283

GO:0009408

GO:0015630

GO:0016020

GO:0022414

GO:0030317

GO:0030521

GO:0030544

GO:0030957

GO:0031072

GO:0031397

GO:0031625

GO:0042026

GO:0043065

GO:0043066

GO:0043226

GO:0043508

GO:0046872

GO:0048471

GO:0048870

GO:0050750

GO:0051082

GO:0051087

GO:0051223

GO:0055131

GO:0070062

GO:0070585

GO:0098554

GO:0098772

GO:1903748

GO:1905259

HMNXSV003027726

Hs.94.0.S2_3p_at

ILMN_1672496

L08069_at

TC09000134.hg

g4504510_3p_a_at

Participates

as a component of

DNAJA1 dimer [cytosol] (Homo sapiens)

as an input of

Reactive oxygen species oxidize DNAJA1 (Homo sapiens)

Other forms of this molecule

SOH-C149,C150-DNAJA1 [cytosol]

Inferred To

dnj-12 [cytosol] (Caenorhabditis elegans)

ddj1 [cytosol] (Dictyostelium discoideum)

dnaja1 [cytosol] (Danio rerio)

dnaja1 [cytosol] (Xenopus tropicalis)

Droj2 [cytosol] (Drosophila melanogaster)

DNAJA1 [cytosol] (Bos taurus)

DNAJA1 [cytosol] (Canis familiaris)

DNAJA1 [cytosol] (Gallus gallus)

DNAJA1 [cytosol] (Mus musculus)

DNAJA1 [cytosol] (Rattus norvegicus)

DNAJA1 [cytosol] (Sus scrofa)

DNAJA4 [cytosol] (Plasmodium falciparum)

DNAJA4 [cytosol] (Saccharomyces cerevisiae)

DNAJA4 [cytosol] (Schizosaccharomyces pombe)

Cross References

OpenTargets

ENSG00000086061

ENSEMBL

ENSP00000369127, ENST00000330899

HPA

ENSG00000086061-DNAJA1

ZINC - Substances

DNJA1_HUMAN

ZINC target

P31689

PRO

P31689

Pharos - Targets

P31689

GlyGen

P31689

PDB

2LO1, 2M6Y, 8E2O, 6E8M

HMDB Protein

HMDBP12598

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.774	27
UniProt:Q71U36 TUBA1A	9	TUBA1A [cytosol] (R-HSA-191689) TUBA1A [axonemal microtubule] (R-HSA-5610433) TUBA1A(1-450) [cytosol] (R-HSA-8955577) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428) TUBA1A unfolded [cytosol] (R-HSA-392767) TUBA1A folding intermediate [cytosol] (R-HSA-392805) Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) AcK-TUBA1A [cytosol] (R-HSA-5618312)	0.671	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	17
UniProt:Q14249 NUCG			0.643	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.569	8
UniProt:O60260-5 PRKN			0.556	6
UniProt:Q9Y333 LSM2	2	LSM2 [nucleoplasm] (R-HSA-71894) LSM2 [cytosol] (R-HSA-429849)	0.553	2
UniProt:Q9UBN7 HDAC6	4	HDAC6 [lysosomal lumen] (R-HSA-9660002) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [nucleoplasm] (R-HSA-351589)	0.527	2
UniProt:P51617 IRAK1	14	IRAK1 [cytosol] (R-HSA-446639) p-2S,S376,T,T209,T387-IRAK1 [cytosol] (R-HSA-446682) p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (R-HSA-937011) p-T209,T387-IRAK1 [plasma membrane] (R-HSA-166279) p-T209-IRAK1 [plasma membrane] (R-HSA-937031) IRAK1 [plasma membrane] (R-HSA-937045) p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] (R-HSA-975157) IRAK1 [endosome membrane] (R-HSA-975127) p-T209,T387-IRAK1 [endosome membrane] (R-HSA-975117) p-T209-IRAK1 [endosome membrane] (R-HSA-975189) K63polyUb-hp-IRAK1 [cytosol] (R-HSA-451565) p-S376,T387-IRAK1 [cytosol] (R-HSA-446687) K63polyUb-hp-IRAK1 [endosome membrane] (R-HSA-975112) p-S,T-IRAK1 [cytosol] (R-HSA-3149574)	0.527	2
UniProt:Q9Y266 NUDC	4	NUDC [cytosol] (R-HSA-377731) NUDC [nucleoplasm] (R-HSA-156716) p-S274,S326-NUDC [cytosol] (R-HSA-156702) p-S274,S326-NUDC [spindle] (R-HSA-9648125)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:O95714 HERC2	5	HERC2 [nucleoplasm] (R-HSA-4551680) p-T4827-HERC2 [nucleoplasm] (R-HSA-5682601) p-T4827,SUMO1-HERC2 [nucleoplasm] (R-HSA-5682615) HERC2 [cytosol] (R-HSA-975975) monoSUMO1-HERC2 [nucleoplasm] (R-HSA-4551758)	0.527	2
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.527	2
UniProt:O60884 DNAJA2	1	DNAJA2 [cytosol] (R-HSA-3371555)	0.527	3
UniProt:Q86U44 METTL3	1	METTL3 [nucleoplasm] (R-HSA-72091)	0.527	2
UniProt:Q8WW22 DNAJA4	1	DNAJA4 [cytosol] (R-HSA-3371578)	0.527	2
UniProt:Q9BXB4 OSBPL11	1	OSBPL11 [plasma membrane] (R-HSA-9714667)	0.527	2
UniProt:Q9GZX7 AICDA	1	AICDA [nucleoplasm] (R-HSA-452477)	0.499	6
UniProt:A0A096LP01 SIM26			0.462	2

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