Reactome | DNAJA1 [cytosol]

DNAJA1 [cytosol]

Stable Identifier

R-HSA-3371544

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

DnaJ homolog subfamily A member 1, DnaJ protein homolog 2, HSDJ, Heat shock 40 kDa protein 4

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P31689 DNAJA1

Gene Names

DNAJA1, DNAJ2, HDJ2, HSJ2, HSPF4

Chain

chain:1-394, propeptide:395-397

Reference Genes

BioGPS Gene:3301 DNAJA1

COSMIC (genes):DNAJA1 DNAJA1

CTD Gene:3301 DNAJA1

dbSNP Gene:3301 DNAJA1

ENSEMBL:ENSG00000086061 DNAJA1

ENSEMBL:ENSG00000086061.16 DNAJA1

HGNC:5229 DNAJA1

KEGG Gene (Homo sapiens):3301 DNAJA1

Monarch:3301 DNAJA1

NCBI Gene:3301 DNAJA1

OMIM:602837 DNAJA1

UCSC:P31689 DNAJA1

Reference Transcript

RefSeq:NM_001539.3 DNAJA1

Other Identifiers

11717188_s_at

11717189_x_at

11760005_x_at

11761703_s_at

11764037_s_at

17084237

200880_PM_at

200880_at

200881_PM_s_at

200881_s_at

2566258

276_at

3166719

3166720

3166721

3166722

3166725

3166726

3166727

3166729

3166731

3166734

3166735

3166736

3301

39118_at

4017318

8154765

A_23_P60479

A_24_P192586

A_24_P9671

GE79841

GE85825

GO:0001664

GO:0001671

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005739

GO:0005783

GO:0005829

GO:0005856

GO:0006457

GO:0006986

GO:0007018

GO:0007283

GO:0009408

GO:0012501

GO:0015630

GO:0016020

GO:0022414

GO:0023052

GO:0030317

GO:0030521

GO:0030544

GO:0030957

GO:0031072

GO:0031397

GO:0031625

GO:0036211

GO:0042026

GO:0043065

GO:0043066

GO:0043226

GO:0043231

GO:0043508

GO:0046872

GO:0048471

GO:0048870

GO:0050750

GO:0051082

GO:0051087

GO:0051223

GO:0055131

GO:0070062

GO:0070585

GO:0098554

GO:0098772

GO:1903748

GO:1905259

HMNXSV003027726

Hs.94.0.S2_3p_at

ILMN_1672496

L08069_at

TC09000134.hg

g4504510_3p_a_at

Participates

as a component of

DNAJA1 dimer [cytosol] (Homo sapiens)

Inferred To

dnj-12 [cytosol] (Caenorhabditis elegans)

ddj1 [cytosol] (Dictyostelium discoideum)

dnaja1 [cytosol] (Xenopus tropicalis)

Droj2 [cytosol] (Drosophila melanogaster)

DNAJA1 [cytosol] (Bos taurus)

DNAJA1 [cytosol] (Canis familiaris)

DNAJA1 [cytosol] (Gallus gallus)

DNAJA1 [cytosol] (Mus musculus)

DNAJA1 [cytosol] (Rattus norvegicus)

DNAJA1 [cytosol] (Sus scrofa)

DNAJA4 [cytosol] (Danio rerio)

DNAJA4 [cytosol] (Plasmodium falciparum)

DNAJA4 [cytosol] (Saccharomyces cerevisiae)

DNAJA4 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001530.1

OpenTargets

ENSG00000086061

ZINC - Substances

DNJA1_HUMAN

HPA

ENSG00000086061-DNAJA1

GeneCards

P31689

Ensembl

ENSG00000086061, ENST00000330899, ENSP00000369127

ZINC target

P31689

PRO

P31689

Pharos - Targets

P31689

PDB

2LO1, 6E8M, 2M6Y

HMDB Protein

HMDBP12598

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.706	19
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	17
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.527	2
UniProt:Q9UBN7 HDAC6	4	HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P51617 IRAK1	14	p-S376,T387-IRAK1 [cytosol] (R-HSA-446687) K63polyUb-hp-IRAK1 [endosome membrane] (R-HSA-975112) p-S,T-IRAK1 [cytosol] (R-HSA-3149574) K63polyUb-hp-IRAK1 [cytosol] (R-HSA-451565) p-T209-IRAK1 [endosome membrane] (R-HSA-975189) p-T209,T387-IRAK1 [endosome membrane] (R-HSA-975117) IRAK1 [endosome membrane] (R-HSA-975127) p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] (R-HSA-975157) IRAK1 [plasma membrane] (R-HSA-937045) p-T209-IRAK1 [plasma membrane] (R-HSA-937031) p-T209,T387-IRAK1 [plasma membrane] (R-HSA-166279) p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (R-HSA-937011) p-2S,S376,T,T209,T387-IRAK1 [cytosol] (R-HSA-446682) IRAK1 [cytosol] (R-HSA-446639)	0.527	2
UniProt:Q9GZX7 AICDA	1	AICDA [nucleoplasm] (R-HSA-452477)	0.499	6

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