DBC1 is phosphorylated by ATM/ART

Stable Identifier
R-HSA-3371567
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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DBC1 is phosphorylated by ATM/ART
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The stress-induced DBC1-SIRT1 interaction required the ATM/ATR-dependent phosphorylation of DBC1 at Thr454 (Yuan J et al. 2012; Zannini L et al. 2012).

Literature References
PubMed ID Title Journal Year
22465953 Regulation of SIRT1 activity by genotoxic stress

Liu, T, Lou, Z, Yuan, J, Luo, K

Genes Dev. 2012
22735644 DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage

Delia, D, Zannini, L, Kim, JE, Buscemi, G, Fontanella, E

J Mol Cell Biol 2012
Participants
Input
Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of ATM/ATR kinase [nucleoplasm]

Physical Entity
ATM/ATR kinase [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Shamovsky, V  (2013-10-29)
Reviewed
Pani, B  (2014-02-17)
Created
Shamovsky, V  (2013-05-13)
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