Reactome | p-Y420-TXK [cytosol]

p-Y420-TXK [cytosol]

Stable Identifier

R-HSA-3448734

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P42681 TXK

Gene Names

TXK, PTK4, RLK

Chain

chain:1-527

Reference Genes

BioGPS Gene:7294 TXK

COSMIC (genes):TXK TXK

CTD Gene:7294 TXK

dbSNP Gene:7294 TXK

ENSEMBL:ENSG00000074966.11 TXK

HGNC:12434 TXK

KEGG Gene (Homo sapiens):7294 TXK

Monarch:7294 TXK

NCBI Gene:7294 TXK

OMIM:600058 TXK

UCSC:P42681 TXK

Reference Transcript

RefSeq:NM_003328.2 TXK

Other Identifiers

0005420711

1029_s_at

11740261_a_at

11759347_x_at

1600_at

16975751

206828_PM_at

206828_at

2768355

2768356

2768357

2768358

2768360

2768362

2768363

2768367

2768369

2768371

2768372

2768374

2768377

2768378

2768379

2768380

2768381

2768395

33490_at

70269_r_at

7294

8100210

A_24_P921122

GE79236

GO:0000166

GO:0001819

GO:0002250

GO:0002376

GO:0004672

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005622

GO:0005634

GO:0005737

GO:0005886

GO:0006351

GO:0006355

GO:0006468

GO:0007202

GO:0007229

GO:0010468

GO:0010543

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0023052

GO:0032729

GO:0036211

GO:0042060

GO:0042246

GO:0043226

GO:0045944

GO:0046777

GO:0048856

GO:0050852

GO:0060335

GO:0098542

GO:0140096

HMNXSV003013612

ILMN_1741143

L27071_at

PH_hs_0002577

TC04001173.hg

g4507742_3p_at

Participates

as a candidate of

p-TEC kinases [cytosol] (Homo sapiens)

Other forms of this molecule

TXK [cytosol]

p-Y91,Y420-TXK [cytosol]

Inferred To

phospho-p-Y420-TXK [cytosol] (Bos taurus)

phospho-p-Y420-TXK [cytosol] (Canis familiaris)

phospho-p-Y420-TXK [cytosol] (Danio rerio)

phospho-p-Y420-TXK [cytosol] (Drosophila melanogaster)

phospho-p-Y420-TXK [cytosol] (Gallus gallus)

phospho-p-Y420-TXK [cytosol] (Mus musculus)

phospho-p-Y420-TXK [cytosol] (Rattus norvegicus)

phospho-p-Y420-TXK [cytosol] (Sus scrofa)

phospho-p-Y420-TXK [cytosol] (Xenopus tropicalis)

Homologues of p-Y420-TXK [cytosol] (Danio rerio)

Modified Residues

Name

O4'-phospho-L-tyrosine at 420

Coordinate

420

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_003319.2

ZINC - World Drugs

TXK_HUMAN

Guide to Pharmacology - Targets

2268

OpenTargets

ENSG00000074966

ZINC - FDA approved

TXK_HUMAN

ZINC - Substances

TXK_HUMAN

ZINC - Biogenic

TXK_HUMAN

ZINC target

P42681

PRO

P42681

PDB

2DM0

ZINC - Investigational

TXK_HUMAN

GeneCards

P42681

HPA

ENSG00000074966-TXK

Ensembl

ENSG00000074966, ENSP00000264316, ENST00000264316

Pharos - Targets

P42681

ZINC - Predictions - Purchasable

TXK_HUMAN

HMDB Protein

HMDBP01145

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UGK3 STAP2	2	p-Y250-STAP2 [plasma membrane] (R-HSA-8848079) STAP2 [cytosol] (R-HSA-8848028)	0.556	3
UniProt:O60496 DOK2	1	DOK2 [cytosol] (R-HSA-204823)	0.556	3
UniProt:O14544 SOCS6	1	SOCS6 [cytosol] (R-HSA-1469969)	0.556	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.556	3
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.556	3
UniProt:O14543 SOCS3	1	SOCS3 [cytosol] (R-HSA-873794)	0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.556	3
UniProt:Q9GZV8 PRDM14	1	PRDM14 [nucleoplasm] (R-HSA-1112608)	0.556	3

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