Pulldown experiments in colorectal cancer cells show an interaction between the C-terminal region of beta-catenin (ARM domains 11 and 12 through the C terminal) with a number of TRRAP-KAT5 HAT complex members including TRRAP, TIP49, p400 and KAT5 (TIP60), among others (Sierra et al, 2006; Bauer et al, 1998; Bauer et al, 2000; Feng et al, 2003). KAT5 and TIP49 have been shown to directly regulate WNT target genes in vivo and are associated with increased H4 acetylation (Bauer et al, 2000; Feng et al, 2003; Kim et al, 2005).
Bauer, A, Chauvet, S, Huber, O, Usseglio, F, Rothbächer, U, Aragnol, D, Kemler, R, Pradel, J
Feng, Y, Lee, N, Fearon, ER
Sierra, J, Yoshida, T, Joazeiro, CA, Jones, KA
Kim, JH, Kim, B, Cai, L, Choi, HJ, Ohgi, KA, Tran, C, Chen, C, Chung, CH, Huber, O, Rose, DW, Sawyers, CL, Rosenfeld, MG, Baek, SH
Bauer, A, Huber, O, Kemler, R
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