Pulldown experiments in colorectal cancer cells show an interaction between the C-terminal region of beta-catenin (ARM domains 11 and 12 through the C terminal) with a number of TRRAP-KAT5 HAT complex members including TRRAP, TIP49, p400 and KAT5 (TIP60), among others (Sierra et al, 2006; Bauer et al, 1998; Bauer et al, 2000; Feng et al, 2003). KAT5 and TIP49 have been shown to directly regulate WNT target genes in vivo and are associated with increased H4 acetylation (Bauer et al, 2000; Feng et al, 2003; Kim et al, 2005).
Feng, Y, Fearon, ER, Lee, N
Kemler, R, Aragnol, D, Bauer, A, Rothbächer, U, Chauvet, S, Pradel, J, Usseglio, F, Huber, O
Yoshida, T, Jones, KA, Sierra, J, Joazeiro, CA
Tran, C, Rosenfeld, MG, Chen, C, Sawyers, CL, Ohgi, KA, Choi, HJ, Cai, L, Baek, SH, Kim, B, Kim, JH, Huber, O, Chung, CH, Rose, DW
Kemler, R, Bauer, A, Huber, O
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