Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CFLAR(1-376) [cytosol]
Stable Identifier
R-HSA-3465408
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
FLIP(L)(1-376), FLIP(L) subunit p43, CASP8 and FADD-like apoptosis regulator Isoform 1 subunit p43, CLARP1, MRIT alpha-1, CASH alpha, I-FLICE 1, FLAME-1 gamma, CASP8 and FADD-like apoptosis regulator
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
Caspase activation via Death Receptors in the presence of ligand (Homo sapiens)
Regulation by c-FLIP (Homo sapiens)
Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
CFLAR(1-376) [cytosol] (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
CASP8 activity is inhibited (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer (Homo sapiens)
CFLAR(1-376) [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
CFLAR(1-376) [cytosol] (Homo sapiens)
RIPK1 is cleaved by CASP8:FLIP(L) (Homo sapiens)
TRADD:TRAF2:RIPK1(325-671):FADD:p43/p41CASP8:p43 FLIP(L) [cytosol] (Homo sapiens)
CFLAR(1-376) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
CFLAR(1-376) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15519-1 CFLAR
Gene Names
CFLAR, CASH, CASP8AP1, CLARP, MRIT
Other Identifiers
11720275_a_at
11746300_x_at
11746342_a_at
11752428_x_at
11753152_x_at
11753252_a_at
11754126_x_at
11756996_x_at
11763231_at
16684142
16889411
16889450
16889452
1867_at
1868_g_at
208485_PM_x_at
208485_x_at
209508_PM_x_at
209508_x_at
209939_PM_x_at
209939_x_at
210563_PM_x_at
210563_x_at
210564_PM_x_at
210564_x_at
211316_PM_x_at
211316_x_at
211317_PM_s_at
211317_s_at
211862_PM_x_at
211862_x_at
214486_PM_x_at
214486_x_at
214618_PM_at
214618_at
217654_PM_at
217654_at
224261_PM_at
224261_at
235427_PM_at
235427_at
237367_PM_x_at
237367_x_at
239629_PM_at
239629_at
2522617
2522618
2522619
2522621
2522623
2522624
2522627
2522628
2522629
2522630
2522631
2522632
2522633
2522635
2522636
2522637
2522638
2522639
2522640
2522641
2522642
2522643
2522644
2522645
2522646
2522647
2522648
2522649
2522650
2522651
2522653
2522655
2522656
2522657
2522658
2522661
2522662
2522663
2522664
2522665
2522668
2522669
2522670
2522671
2522672
2522673
2522674
2522675
2522676
2522677
2522678
2522679
2522680
2522682
2522684
2522686
2522688
2522690
2522692
2522694
2522695
2522696
2522697
2950142
32746_at
50757_at
60911_at
8047381
8047401
82588_at
83754_at
84352_s_at
8837
AF005775_at
A_14_P137243
A_21_P0001952
A_21_P0002336
A_23_P209394
A_24_P120115
GE61439
GE83594
GO:0001666
GO:0002020
GO:0003012
GO:0003824
GO:0004197
GO:0005123
GO:0005515
GO:0005737
GO:0005829
GO:0006355
GO:0006508
GO:0006915
GO:0007010
GO:0007519
GO:0008047
GO:0008234
GO:0010667
GO:0010976
GO:0012501
GO:0014732
GO:0014842
GO:0014866
GO:0016787
GO:0030154
GO:0030182
GO:0030216
GO:0030218
GO:0031264
GO:0031265
GO:0032869
GO:0033574
GO:0042060
GO:0042981
GO:0043066
GO:0043123
GO:0043403
GO:0043525
GO:0044877
GO:0048856
GO:0051092
GO:0060544
GO:0070374
GO:0071364
GO:0071392
GO:0071456
GO:0071549
GO:0071732
GO:0072126
GO:0097190
GO:0097194
GO:0097199
GO:0097200
GO:0097342
GO:0098772
GO:0140096
GO:1901740
GO:1902042
GO:1903055
GO:1903427
GO:1903845
GO:1903944
GO:1904036
GO:2000347
GO:2001237
HMNXSV003005536
HMNXSV003022885
HMNXSV003031977
HMNXSV003057210
Hs.110286.0.A1_3p_at
Hs.157313.0.A1_3p_at
Hs.166913.0.A1_3p_at
Hs.166913.0.A1_3p_s_at
Hs.174303.0.A1_3p_at
Hs.195175.11.S2_3p_at
ILMN_1789830
PH_hs_0023979
TC01002420.hg
TC02001175.hg
TC02003765.hg
TC02003766.hg
TC07000772.hg
TC07000774.hg
TC07001901.hg
TC08001586.hg
TC09000166.hg
TC0X000186.hg
TC0X000206.hg
g2253680_3p_a_at
g2286144_3p_x_at
g2286146_3p_x_at
g2429153_3p_at
g2429159_3p_a_at
g2429159_3p_x_at
g2827295_3p_a_at
g2827295_3p_x_at
g3133282_3p_a_at
g3133282_3p_x_at
p29821
Participates
as a component of
TRADD:TRAF2:RIPK1(325-671):FADD:p43/p41CASP8:p43 FLIP(L) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
as an input of
FLIP(L) and procaspase-8 form heterodimer (Homo sapiens)
Other forms of this molecule
M1polyUb-K351,K353-CFLAR(1-480) [cytosol]
CFLAR(377-480) [cytosol]
K63polyUb-CFLAR(1-480) [cytosol]
CFLAR(1-480) [cytosol]
Inferred To
CASP9 [cytosol]
(Bos taurus)
CASP9 [cytosol]
(Canis familiaris)
CASP9 [cytosol]
(Sus scrofa)
CFLAR(1-376) [cytosol]
(Gallus gallus)
Cflar [cytosol]
(Mus musculus)
Cflar [cytosol]
(Rattus norvegicus)
Cross References
ENSEMBL
ENST00000443227
,
ENSP00000399420
,
ENSP00000342809
,
ENST00000479953
,
ENST00000342795
,
ENSP00000312455
,
ENST00000309955
,
ENSP00000413270
,
ENSP00000406775
,
ENST00000341222
,
ENST00000457277
,
ENST00000423241
,
ENST00000341582
,
ENST00000440180
,
ENSP00000471805
,
ENSP00000411535
,
ENSP00000339335
,
ENSP00000345807
OpenTargets
ENSG00000003402
HPA
ENSG00000003402-CFLAR
PRO
O15519
Pharos - Targets
O15519
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14790 CASP8
8
CASP8(1-374) [cytosol]
(R-HSA-3465404)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(217-374) [cytosol]
(R-HSA-75975)
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(1-479) [cytosol]
(R-HSA-57031)
0.744
10
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.718
6
UniProt:Q92851 CASP10
4
CASP10(220-415) [cytosol]
(R-HSA-933458)
CASP10(1-219) [cytosol]
(R-HSA-933454)
CASP10(416-521) [cytosol]
(R-HSA-933455)
CASP10(1-521) [cytosol]
(R-HSA-933453)
0.65
3
UniProt:Q00G26 PLIN5
0.527
2
UniProt:P50591 TNFSF10
1
TNFSF10 [extracellular region]
(R-HSA-66186)
0.527
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text