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TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol]
Stable Identifier
R-HSA-3465532
Type
Complex
Species
Homo sapiens
Compartment
cytosol
GO Cellular Component
death-inducing signaling complex
(0031264)
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
Caspase activation via Death Receptors in the presence of ligand (Homo sapiens)
Regulation by c-FLIP (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
15024054
N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway
Kataoka, T
,
Tschopp, J
Mol. Cell. Biol.
2004
Participants
components
CASP8(1-479) [cytosol]
(Homo sapiens)
CFLAR(1-480) [cytosol]
(Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol]
(Homo sapiens)
Participates
as an input of
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Homo sapiens)
as an output of
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Homo sapiens)
Inferred To
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol]
(Bos taurus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol]
(Canis familiaris)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol]
(Gallus gallus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol]
(Mus musculus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol]
(Rattus norvegicus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol]
(Sus scrofa)
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