PIAS1,3,4 SUMOylate MTA1 with SUMO2,3

Stable Identifier
R-HSA-3465545
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 at lysine-509 (Cong et al. 2011). SUMOylation increases the repressor activity of MTA1 at the PS2 promoter (Cong et al. 2011).
Literature References
PubMed ID Title Journal Year
21965678 SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function

Ohshiro, K, Kumar, R, Pakala, SB, Cong, L, Li, DQ

J. Biol. Chem. 2011
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Event Information
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Catalyst Activity

SUMO transferase activity of PIAS1,3,4 [nucleoplasm]

Orthologous Events
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