Reactome | Phosphorylation of MDM4 by CHEK2

Phosphorylation of MDM4 by CHEK2

Stable Identifier

R-HSA-349426

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
      - p53-Dependent G1 DNA Damage Response (Homo sapiens)
        
        Stabilization of p53 (Homo sapiens)
        
        Phosphorylation of MDM4 by CHEK2 (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        Phosphorylation of MDM4 by CHEK2 (Homo sapiens)

General

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CHEK2 (Chk2) kinase is required for phosphorylation of MDM4 at serine residues S342 and S367 in vivo. CHEK2-mediated phosphorylation stimulates MDM4 ubiquitination by MDM2 and subsequent degradation (Chen et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
16163388	ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage Lane, WS, Chen, L, Pan, Y, Chen, J, Gilkes, DM	EMBO J	2005