Phosphorylation of MDM4 by CHEK2

Stable Identifier
R-HSA-349426
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Phosphorylation of MDM4 by CHEK2
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CHEK2 (Chk2) kinase is required for phosphorylation of MDM4 at serine residues S342 and S367 in vivo. CHEK2-mediated phosphorylation stimulates MDM4 ubiquitination by MDM2 and subsequent degradation (Chen et al. 2005).
Literature References
PubMed ID Title Journal Year
16163388 ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

Lane, WS, Chen, L, Pan, Y, Chen, J, Gilkes, DM

EMBO J 2005
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-S,3T-CHEK2 [nucleoplasm]

Physical Entity
p-S,3T-CHEK2 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of MDM4 by CHEK2 (Canis familiaris)
Phosphorylation of MDM4 by CHEK2 (Mus musculus)
Phosphorylation of MDM4 by CHEK2 (Rattus norvegicus)
Authored
Matthews, L  (2008-03-31)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Matthews, L  (2008-05-08)
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