Reactome | Phosphorylation of COP1 at Ser-387 by ATM

Phosphorylation of COP1 at Ser-387 by ATM

Stable Identifier

R-HSA-349444

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
      - p53-Dependent G1 DNA Damage Response (Homo sapiens)
        
        Stabilization of p53 (Homo sapiens)
        
        Autodegradation of the E3 ubiquitin ligase COP1 (Homo sapiens)
        
        Phosphorylation of COP1 at Ser-387 by ATM (Homo sapiens)

General

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Phosphorylation of COP1 at Ser-387 by ATM

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ATM phosphorylates COP1 on Ser387 in response to DNA damage (Dornan et al., 2006).

Literature References

PubMed ID	Title	Journal	Year
16931761	ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage Dixit, VM, Shimizu, H, O'Rourke, K, Eby, M, Dornan, D, Dudhela, T, Mah, A, Seshagiri, S	Science	2006