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p-S15-TP53 Tetramer [nucleoplasm]
Stable Identifier
R-HSA-349474
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
p53-Dependent G1 DNA Damage Response (Homo sapiens)
Stabilization of p53 (Homo sapiens)
ATM phosphorylates TP53 at S15 (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
Autodegradation of the E3 ubiquitin ligase COP1 (Homo sapiens)
Dissociation of the COP1-p53 complex (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
p-S387-RFWD2:p-S15-TP53 [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
CHEK2 phosphorylates TP53 (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
G2/M DNA damage checkpoint (Homo sapiens)
ATR phosphorylates TP53 (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
CHEK1 phosphorylates TP53 (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
ATM phosphorylates TP53 at S15 (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
EP400 binds CDKN1A promoter (Homo sapiens)
EP400:p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
Formation of Senescence-Associated Heterochromatin Foci (SAHF) (Homo sapiens)
SAHF formation (Homo sapiens)
EP400:p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 binds the CDKN1A promoter (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
Transcriptional activation of CDKN1A by TP53 is inhibited by EP400 (Homo sapiens)
EP400:p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
ATM phosphorylates TP53 at S15 (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Maternal to zygotic transition (MZT) (Homo sapiens)
Zygotic genome activation (ZGA) (Homo sapiens)
DPPA2, DPPA4 and TP53 bind the DUX4 gene cluster (Homo sapiens)
DPPA2:DPPA4:p-S15-TP53:DUX4 gene [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
Expression of DUX4 in the zygote (Homo sapiens)
DPPA2:DPPA4:p-S15-TP53:DUX4 gene [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
AMPK phosphorylates TP53 (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
ATM phosphorylates TP53 at S15 (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
ATR phosphorylates TP53 (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
CHEK1 phosphorylates TP53 (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
CHEK2 phosphorylates TP53 (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
PLK3 phosphorylates TP53 (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53RK phosphorylates TP53 (Homo sapiens)
p-S15-TP53 Tetramer [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
7850419
Allosteric activation of latent p53 tetramers
Lane, DP
,
Hupp, TR
Curr Biol
1994
Participants
components
x 4
p-S15-TP53 [nucleoplasm]
(Homo sapiens)
Participates
as an input of
DPPA2, DPPA4 and TP53 bind the DUX4 gene cluster (Homo sapiens)
TP53 binds the CDKN1A promoter (Homo sapiens)
CHEK1 phosphorylates TP53 (Homo sapiens)
CHEK2 phosphorylates TP53 (Homo sapiens)
PLK3 phosphorylates TP53 (Homo sapiens)
as a component of
DPPA2:DPPA4:p-S15-TP53:DUX4 gene [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm] (Homo sapiens)
p-S387-RFWD2:p-S15-TP53 [nucleoplasm] (Homo sapiens)
as an output of
AMPK phosphorylates TP53 (Homo sapiens)
ATM phosphorylates TP53 at S15 (Homo sapiens)
Dissociation of the COP1-p53 complex (Homo sapiens)
ATR phosphorylates TP53 (Homo sapiens)
TP53RK phosphorylates TP53 (Homo sapiens)
This entity regulates
Positively
SAHF formation
(Homo sapiens)
Inferred To
p-S15-TP53 Tetramer [nucleoplasm]
(Bos taurus)
p-S15-TP53 Tetramer [nucleoplasm]
(Canis familiaris)
p-S15-TP53 Tetramer [nucleoplasm]
(Danio rerio)
p-S15-TP53 Tetramer [nucleoplasm]
(Drosophila melanogaster)
p-S15-TP53 Tetramer [nucleoplasm]
(Mus musculus)
p-S15-TP53 Tetramer [nucleoplasm]
(Rattus norvegicus)
p-S15-TP53 Tetramer [nucleoplasm]
(Sus scrofa)
p-S15-TP53 Tetramer [nucleoplasm]
(Xenopus tropicalis)
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