Reactome | CLU(23-449) [extracellular region]

CLU(23-449) [extracellular region]

Stable Identifier

R-HSA-349732

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Clusterin, CLU

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P10909 CLU

Gene Names

CLU, APOJ, CLI, KUB1, AAG4

Chain

signal peptide:1-22, chain:23-449, chain:23-227, chain:228-449

Reference Genes

BioGPS Gene:1191 CLU

COSMIC (genes):CLU CLU

CTD Gene:1191 CLU

dbSNP Gene:1191 CLU

ENSEMBL:ENSG00000120885 CLU

HGNC:2095 CLU

KEGG Gene (Homo sapiens):1191 CLU

Monarch:1191 CLU

NCBI Gene:1191 CLU

OMIM:185430 CLU

UCSC:P10909 CLU

Reference Transcript

RefSeq:NM_001831.3 CLU

Other Identifiers

0003870717

0101450524

11715851_s_at

11756547_a_at

1191

17075731

208791_at

208792_s_at

222043_at

3129071

3129072

3129073

3129074

3129075

3129076

3129077

3129078

3129079

3129081

3129083

3129085

3129086

3129087

3129088

3129089

3129090

3129092

3129093

3129096

3129097

3129098

3129099

3129100

3129101

3129102

3129103

3129104

3129105

3129109

36780_at

43817_f_at

63969_f_at

75382_i_at

75384_f_at

80587_s_at

8149927

A_23_P215913

GE479016

GE61669

GE79935

GO:0000902

GO:0001540

GO:0001774

GO:0001836

GO:0002376

GO:0002434

GO:0002576

GO:0003674

GO:0005102

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005739

GO:0005743

GO:0005783

GO:0005794

GO:0005829

GO:0005856

GO:0006457

GO:0006464

GO:0006605

GO:0006629

GO:0006810

GO:0006914

GO:0006915

GO:0006950

GO:0006956

GO:0006958

GO:0007005

GO:0007009

GO:0007034

GO:0007165

GO:0008092

GO:0008150

GO:0008219

GO:0008283

GO:0009056

GO:0009058

GO:0009615

GO:0009986

GO:0010628

GO:0015031

GO:0016020

GO:0016192

GO:0017038

GO:0019730

GO:0019899

GO:0022607

GO:0030154

GO:0030449

GO:0031012

GO:0031093

GO:0031333

GO:0031334

GO:0031410

GO:0031625

GO:0031966

GO:0032286

GO:0032436

GO:0032760

GO:0032991

GO:0034366

GO:0034641

GO:0042127

GO:0042583

GO:0042981

GO:0043065

GO:0043226

GO:0043231

GO:0043691

GO:0044877

GO:0045087

GO:0045202

GO:0045429

GO:0048156

GO:0048260

GO:0048471

GO:0048856

GO:0050750

GO:0050821

GO:0051082

GO:0051087

GO:0051092

GO:0051131

GO:0051787

GO:0051788

GO:0055085

GO:0060548

GO:0061024

GO:0061077

GO:0061518

GO:0061740

GO:0061741

GO:0062023

GO:0065003

GO:0070062

GO:0071944

GO:0072562

GO:0090201

GO:0097418

GO:0097440

GO:0099020

GO:1900221

GO:1901214

GO:1901216

GO:1902004

GO:1902230

GO:1902430

GO:1902847

GO:1902949

GO:1902998

GO:1903573

GO:1905892

GO:1905895

GO:1905907

GO:1905908

GO:2000060

HMNXSV003026147

HMNXSV003030892

Hs.75106.1.S1_3p_at

ILMN_1691483

ILMN_1724895

ILMN_1798298

M63379_at

PH_hs_0025525

TC08001081.hg

TC08002263.hg

g180619_3p_a_at

g180619_3p_at

Participates

as a member of

Platelet alpha granule contents [extracellular region] (Homo sapiens)

Other forms of this molecule

CLU(23-449) [platelet alpha granule lumen]

CLU(228-449) [extracellular region]

CLU(23-227) [extracellular region]

Inferred To

Clu [extracellular region] (Mus musculus)

Clu [extracellular region] (Rattus norvegicus)

clu [extracellular region] (Danio rerio)

CLU [extracellular region] (Bos taurus)

CLU [extracellular region] (Canis familiaris)

CLU [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_001822.3

Guide to Pharmacology - Targets

3195

OpenTargets

ENSG00000120885

GeneCards

P10909

HPA

ENSG00000120885-CLU

Ensembl

ENST00000316403, ENSP00000315130, ENST00000523500, ENSP00000429620, ENSG00000120885, ENSP00000385419, ENST00000405140

PRO

P10909

Pharos - Targets

P10909

GlyGen

P10909

Orphanet

24348

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P37840 SNCA	4	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) SNCA [cytosol] (R-HSA-5658500) Ub-SNCA [cytosol] (R-HSA-5660754)	0.662	4
UniProt:P30101 PDIA3	3	PDIA3 [phagocytic vesicle] (R-HSA-1236870) PDIA3 [recycling endosome membrane] (R-HSA-8863849) PDIA3 [endoplasmic reticulum lumen] (R-HSA-901028)	0.59	2
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P18509 ADCYAP1	4	ADCYAP1(2-742) [Golgi membrane] (R-HSA-187679) ADCYAP1(132-169) [extracellular region] (R-HSA-420282) ADCYAP1(82-129) [extracellular region] (R-HSA-420254) ADCYAP1(132-158) [extracellular region] (R-HSA-420144)	0.543	4
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.524	2
UniProt:P37231 PPARG	2	monoSUMO1-K107,K395-PPARG [nucleoplasm] (R-HSA-4717444) PPARG [nucleoplasm] (R-HSA-446172)	0.524	3