Reactome | LRP2 [plasma membrane]

LRP2 [plasma membrane]

Stable Identifier

R-HSA-350083

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Megalin, Low-density lipoprotein receptor-related protein 2 precursor, LRP2_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        LRP2:DAB2 [plasma membrane] (Homo sapiens)
        
        LRP2 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        LRP2:DAB2 [plasma membrane] (Homo sapiens)
        
        LRP2 [plasma membrane] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        LRP2:DAB2 [plasma membrane] (Homo sapiens)
        
        LRP2 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        LRP2:DAB2 [plasma membrane] (Homo sapiens)
        
        LRP2 [plasma membrane] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - DAB2 binds LRP2 (Homo sapiens)
        
        LRP2 [plasma membrane] (Homo sapiens)
        
        LRP2:DAB2 [plasma membrane] (Homo sapiens)
        
        LRP2 [plasma membrane] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        LRP2:DAB2 [plasma membrane] (Homo sapiens)
        
        LRP2 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        LRP2:DAB2 [plasma membrane] (Homo sapiens)
        
        LRP2 [plasma membrane] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        LRP2:DAB2 [plasma membrane] (Homo sapiens)
        
        LRP2 [plasma membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        LRP2:DAB2 [plasma membrane] (Homo sapiens)
        
        LRP2 [plasma membrane] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        LRP2:DAB2 [plasma membrane] (Homo sapiens)
        
        LRP2 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        LRP2:DAB2 [plasma membrane] (Homo sapiens)
        
        LRP2 [plasma membrane] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        LRP2:DAB2 [plasma membrane] (Homo sapiens)
        
        LRP2 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        LRP2:DAB2 [plasma membrane] (Homo sapiens)
        
        LRP2 [plasma membrane] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        LRP2:DAB2 [plasma membrane] (Homo sapiens)
        
        LRP2 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        LRP2:DAB2 [plasma membrane] (Homo sapiens)
        
        LRP2 [plasma membrane] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        LRP2:DAB2 [plasma membrane] (Homo sapiens)
        
        LRP2 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        LRP2:DAB2 [plasma membrane] (Homo sapiens)
        
        LRP2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P98164 LRP2

Gene Names

LRP2

Chain

signal peptide:1-25, chain:26-4655

Reference Genes

BioGPS Gene:4036 LRP2

COSMIC (genes):LRP2 LRP2

CTD Gene:4036 LRP2

dbSNP Gene:4036 LRP2

ENSEMBL:ENSG00000081479 LRP2

ENSEMBL_homo_sapiens_GENE:ENSG00000081479.15 LRP2

HGNC:6694 LRP2

KEGG Gene (Homo sapiens):4036 LRP2

Monarch:4036 LRP2

NCBI Gene:4036 LRP2

OMIM:600073 LRP2

UCSC:P98164 LRP2

Reference Transcript

RefSeq:NM_004525.2 LRP2

Other Identifiers

11727122_at

11727123_at

11727124_s_at

11751976_a_at

11752123_a_at

16904827

205710_PM_at

205710_at

230863_PM_at

230863_at

2586039

2586040

2586041

2586042

2586043

2586047

2586048

2586049

2586050

2586051

2586052

2586053

2586056

2586057

2586062

2586063

2586064

2586065

2586066

2586067

2586068

2586069

2586070

2586072

2586075

2586078

2586079

2586080

2586081

2586084

2586087

2586088

2586090

2586093

2586096

2586097

2586101

2586102

2586103

2586106

2586107

2586108

2586110

2586111

2586112

2586113

2586114

2586115

2586116

2586117

2586118

2586119

2586120

2586121

2586123

2586124

2586128

2586129

2586130

2586131

2586132

2586133

2586134

2586135

2586138

2586139

2586140

2586141

2586142

2586143

2586144

2586145

2586146

2586147

2586149

2586150

2586151

2586152

2586153

2586154

2586155

2586158

2586159

2586160

2586161

2586163

2586164

2586166

2586167

2586168

2586169

2586171

2586172

2586179

2586180

35009_at

4036

8056611

85083_at

A_23_P28295

A_33_P3244728

GE79196

GE88293

GO:0001523

GO:0001822

GO:0001843

GO:0003013

GO:0003139

GO:0003148

GO:0003223

GO:0003281

GO:0005041

GO:0005215

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005783

GO:0005794

GO:0005886

GO:0005903

GO:0005905

GO:0006629

GO:0006766

GO:0006897

GO:0006898

GO:0007399

GO:0007507

GO:0007605

GO:0008283

GO:0008584

GO:0009897

GO:0012501

GO:0015031

GO:0015889

GO:0016020

GO:0016192

GO:0016324

GO:0017124

GO:0022414

GO:0023052

GO:0030001

GO:0030139

GO:0030154

GO:0030163

GO:0030424

GO:0030425

GO:0030514

GO:0030669

GO:0030900

GO:0031410

GO:0031526

GO:0031904

GO:0031994

GO:0034311

GO:0035904

GO:0038024

GO:0042359

GO:0042562

GO:0042995

GO:0043066

GO:0043226

GO:0043235

GO:0043491

GO:0044321

GO:0045056

GO:0045177

GO:0046872

GO:0048856

GO:0050769

GO:0050877

GO:0051087

GO:0055085

GO:0060068

GO:0060976

GO:0060982

GO:0061156

GO:0070062

GO:0070447

GO:0071363

GO:0097242

GO:0140058

GO:0140318

GO:0150104

GO:1904447

GO:1905167

HMNXSV003021451

Hs.252938.0.A1_3p_at

ILMN_1723443

PH_hs_0023246

TC02002509.hg

U33837_at

g6806918_3p_at

Participates

as an input of

DAB2 binds LRP2 (Homo sapiens)

as a component of

as a member of

LRPs [plasma membrane] (Homo sapiens)

Other forms of this molecule

LRP2 [clathrin-coated endocytic vesicle membrane]

Inferred To

LRP2 [plasma membrane] (Bos taurus)

LRP2 [plasma membrane] (Canis familiaris)

LRP2 [plasma membrane] (Gallus gallus)

LRP2 [plasma membrane] (Mus musculus)

LRP2 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_004516.2

OpenTargets

ENSG00000081479

GeneCards

P98164

HPA

ENSG00000081479-LRP2

Ensembl

ENSP00000496870, ENST00000649046, ENSG00000081479

PRO

P98164

Pharos - Targets

P98164

Orphanet

17390

PDB

2M0P

HMDB Protein

HMDBP02726

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H4K1 RIBC2			0.589	2
UniProt:Q9P031 CCDC59	1	CCDC59 [nucleoplasm] (R-HSA-5683813)	0.527	2
UniProt:Q9H8J5 MANS1			0.527	2
UniProt:Q9NQ76 MEPE	2	p-MEPE [endoplasmic reticulum lumen] (R-HSA-8957045) MEPE [endoplasmic reticulum lumen] (R-HSA-8956744)	0.527	2
UniProt:Q9NZL3 ZNF224	1	ZNF224 [nucleoplasm] (R-HSA-1027352)	0.527	2
UniProt:Q8N8Y5 ZFP41			0.527	2
UniProt:Q9H9D4 ZN408			0.527	2
UniProt:P30533 AMRP			0.527	2
UniProt:Q9Y581 INSL6			0.527	2
UniProt:Q9BQB4 SOST	1	SOST [extracellular region] (R-HSA-3769322)	0.527	2
UniProt:O43296 ZNF264	1	ZNF264 [nucleoplasm] (R-HSA-1027386)	0.527	2
UniProt:P29279 CTGF	1	CTGF [extracellular region] (R-HSA-561148)	0.527	2

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