Reactome | LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D

LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D

Stable Identifier

R-HSA-350168

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region, cytosol

ReviewStatus

5/5

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LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D

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Megalin (LRP2, glycoprotein 330) is a member of the low density lipoprotein receptor family and is abundant in kidney proximal tubules (Kounnas et al. 1995, Hjalm et al. 1996). LRP2 complexed with LDLRAP1 (low density lipoprotein receptor adapter protein 1, aka ARH) mediates the endocytic uptake of GC:25(OH)D complexes, thereby preventing the loss of 25-hydroxyvitamin D (calcidiol, 25(OH)D) in urine (Nykjaer et al. 1999, Kaseda et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21595846	Role of megalin and cubilin in the metabolism of vitamin D(3) Hosojima, M, Sato, H, Kaseda, R, Saito, A	Ther Apher Dial	2011
10052453	An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3 Melsen, F, Christensen, EI, Jacobsen, C, Vorum, H, Nykjaer, A, Willnow, TE, Herz, J, Walther, D, Dragun, D	Cell	1999
7768901	Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin Brewer, BH, Stefansson, S, Harmony, JA, Loukinova, EB, Kounnas, MZ, Strickland, DK, Argraves, WS	J Biol Chem	1995
8706697	Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties Lundgren, S, Murray, E, Larsson, M, Crumley, G, Hellman, P, Akerstrom, G, Juhlin, C, Ek, B, Morse, B, Davis, H, Rask, L, Onyango, I, Harazim, W, Hjalm, G	Eur J Biochem	1996