Reactome | MED4 [nucleoplasm]

MED4 [nucleoplasm]

Stable Identifier

R-HSA-350263

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

MED4_HUMAN

Locations in the PathwayBrowser for interactor UniProt:A2BDD9 A2BDD9

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External Reference Information

External Reference

UniProt:Q9NPJ6 MED4

Gene Names

MED4, ARC36, DRIP36, VDRIP, HSPC126

Chain

initiator methionine:, chain:2-270

Reference Genes

BioGPS Gene:29079 MED4

COSMIC (genes):MED4 MED4

CTD Gene:29079 MED4

dbSNP Gene:29079 MED4

ENSEMBL:ENSG00000136146 MED4

HGNC:17903 MED4

KEGG:hsa:29079 MED4

Monarch:29079 MED4

NCBI Gene:29079 MED4

OMIM:605718 MED4

UCSC:Q9NPJ6 MED4

Reference Transcript

Other Identifiers

11720497_at

11758836_at

16778987

217843_PM_s_at

217843_s_at

222438_PM_at

222438_at

29079

3513396

3513401

3513402

3513403

3513404

3513408

3513411

3513413

3513414

3513415

3513416

3513417

3513418

3513419

3513420

60538_at

78692_at

7971550

A_23_P128543

A_33_P3369766

GE61653

GO:0003712

GO:0003713

GO:0005515

GO:0005634

GO:0005654

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0016020

GO:0016592

GO:0030374

GO:0032968

GO:0042809

GO:0043226

GO:0045893

GO:0046966

GO:0051123

GO:0060090

GO:0060261

GO:0065003

GO:0070847

GO:0140110

HMNXSV003040949

Hs.181112.0.A3_3p_at

ILMN_1664641

PH_hs_0010716

TC13000653.hg

TC13001486.hg

g7661787_3p_a_at

Participates

as a component of

as an input of

Inferred To

med4 [nucleoplasm] (Danio rerio)

MED4 [nucleoplasm] (Bos taurus)

MED4 [nucleoplasm] (Canis familiaris)

MED4 [nucleoplasm] (Drosophila melanogaster)

MED4 [nucleoplasm] (Gallus gallus)

MED4 [nucleoplasm] (Sus scrofa)

Med4 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_054885.1, NP_001257558.1

OpenTargets

ENSG00000136146

ENSEMBL

ENST00000378586, ENSP00000367849, ENST00000258648, ENSP00000258648

HPA

ENSG00000136146-MED4

PRO

Q9NPJ6

Pharos - Targets

Q9NPJ6

GlyGen

Q9NPJ6

PDB

7EMF, 7ENC, 7ENA, 7NVR, 7LBM, 7ENJ, 8GXS, 8GXQ

Interactors (96)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.909	12
UniProt:Q9NWA0 MED9	1	MED9 [nucleoplasm] (R-HSA-556804)	0.895	17
UniProt:P49336 CDK8	1	CDK8 [nucleoplasm] (R-HSA-212440)	0.886	13
UniProt:A0JLT2 MED19	1	MED19 [nucleoplasm] (R-HSA-556819)	0.886	11
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.873	15
UniProt:Q13503 MED21	1	MED21 [nucleoplasm] (R-HSA-212456)	0.859	11
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.841	9
UniProt:Q93074 MED12	1	MED12 [nucleoplasm] (R-HSA-212343)	0.834	12
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.802	9
UniProt:Q9BUE0 MED18	1	MED18 [nucleoplasm] (R-HSA-556826)	0.802	9
UniProt:Q9BWU1 CDK19	1	CDK19 [nucleoplasm] (R-HSA-556782)	0.802	8
UniProt:O43513 MED7	1	MED7 [nucleoplasm] (R-HSA-212430)	0.788	7
UniProt:Q9NX70 MED29	1	MED29 [nucleoplasm] (R-HSA-556821)	0.788	9
UniProt:O95379 TNFAIP8	1	TNFAIP8 [cytosol] (R-HSA-8874463)	0.781	7
UniProt:Q9Y3C7 MED31	1	MED31 [nucleoplasm] (R-HSA-212429)	0.745	7
UniProt:Q9ULK4 MED23	1	MED23 [nucleoplasm] (R-HSA-556823)	0.745	10
UniProt:Q96HR3 MED30	1	MED30 [nucleoplasm] (R-HSA-212398)	0.745	7
UniProt:Q8N3L3 TXLNB			0.742	6
UniProt:Q8IY31 IFT20	3	IFT20 [ciliary tip] (R-HSA-5625355) IFT20 [Golgi membrane] (R-HSA-5617625) IFT20 [cilium] (R-HSA-5617624)	0.742	6
UniProt:Q8TD31-3 CCHCR1			0.718	6
UniProt:Q8N6Y0 USBP1			0.718	6
UniProt:Q96GM5 SMARCD1	1	SMARCD1 [nucleoplasm] (R-HSA-389255)	0.718	6
UniProt:Q99909 SSX3			0.718	6
UniProt:Q71F56 MED13L	1	MED13L [nucleoplasm] (R-HSA-556797)	0.706	7
UniProt:Q15154 PCM1	1	PCM1 [cytosol] (R-HSA-380308)	0.691	7
UniProt:Q9H204 MED28	1	MED28 [nucleoplasm] (R-HSA-6804546)	0.671	7
UniProt:Q9P086 MED11	1	MED11 [nucleoplasm] (R-HSA-556808)	0.671	6
UniProt:Q15528 MED22	1	MED22 [nucleoplasm] (R-HSA-556779)	0.671	6
UniProt:Q6P2C8 MED27	1	MED27 [nucleoplasm] (R-HSA-556761)	0.671	6
UniProt:Q9UHV7 MED13	1	MED13 [nucleoplasm] (R-HSA-212391)	0.671	6
UniProt:Q9H944 MED20	1	MED20 [nucleoplasm] (R-HSA-212428)	0.671	8
UniProt:O60244 MED14	1	MED14 [nucleoplasm] (R-HSA-212441)	0.671	7
UniProt:O75448 MED24	1	MED24 [nucleoplasm] (R-HSA-212331)	0.671	6
UniProt:O75586 MED6	1	MED6 [nucleoplasm] (R-HSA-212359)	0.671	6
UniProt:Q96G25 MED8	1	MED8 [nucleoplasm] (R-HSA-556784)	0.671	6
UniProt:Q9NVC6 MED17	1	MED17 [nucleoplasm] (R-HSA-212401)	0.671	6
UniProt:Q6PIF2 SYCE2	1	SYCE2 [nucleoplasm] (R-HSA-912451)	0.666	4
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.666	4
UniProt:O14777 NDC80	1	NDC80 [cytosol] (R-HSA-375314)	0.659	4
UniProt:Q96CS2 HAUS1	1	HAUS1 [cytosol] (R-HSA-8855199)	0.659	4
UniProt:Q9Y2X0 MED16	1	MED16 [nucleoplasm] (R-HSA-556802)	0.643	5
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.643	5
UniProt:Q71SY5 MED25	1	MED25 [nucleoplasm] (R-HSA-212414)	0.643	5
UniProt:Q96RN5 MED15	1	MED15 [nucleoplasm] (R-HSA-556827)	0.643	5
UniProt:O95721 SNAP29	3	SNAP29 [azurophil granule membrane] (R-HSA-6799359) SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997)	0.569	4
UniProt:Q96M89 CC138			0.569	4
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.569	4
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.569	4
UniProt:Q96CN9 GCC1	1	GCC1 [cytosol] (R-HSA-6813877)	0.556	3
UniProt:P48232 SNAPN			0.556	3
IntAct:EBI-22419101 CCSB ORF ID			0.556	3
UniProt:Q8NE31 FA13C			0.556	3
UniProt:Q969G3 SMARCE1	1	SMARCE1 [nucleoplasm] (R-HSA-389258)	0.556	3
UniProt:P48837	1	NUP57 [nuclear envelope] (R-SCE-157724)	0.556	3
UniProt:P40325 HUA1			0.556	3
UniProt:Q8TAB5 CA216			0.556	3
IntAct:EBI-11522208 YLR445W			0.556	3
UniProt:P32502	1	GCD7 [cytosol] (R-SCE-72519)	0.556	3
UniProt:Q96NE9 FRMD6			0.556	3
UniProt:Q8WVP5 TNFAIP8L1	1	TNFAIP8L1 [cytosol] (R-HSA-8874482)	0.556	3
UniProt:Q8IYE0-2 CCDC146			0.556	3
UniProt:Q8WYA6 CTNNBL1	1	CTNNBL1 [nucleoplasm] (R-HSA-5420895)	0.556	3
UniProt:Q8N8X9 MB213			0.556	3
UniProt:Q32MZ4-4 LRRFIP1			0.556	3
UniProt:Q9BVG8 KIFC3			0.556	3
UniProt:A2BDD9 A2BDD9			0.556	3
UniProt:P39518	1	ACSL5 [endoplasmic reticulum membrane] (R-SCE-165011)	0.556	3
UniProt:O95954 FTCD	1	FTCD [cytosol] (R-HSA-70907)	0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.556	3
UniProt:Q96PC2 IP6K3	1	IP6K3 [cytosol] (R-HSA-1604594)	0.556	3
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:Q4VCS5-2 AMOT	1	AMOT-2 [cytosol] (R-HSA-9761473)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.556	3
UniProt:Q96ES7 SGF29	1	SGF29 [nucleoplasm] (R-HSA-3662279)	0.556	3
UniProt:Q5TB80 CEP162	1	CEP162 [cytosol] (R-HSA-5626646)	0.528	3
UniProt:O15078 CEP290	3	CEP290 [extracellular region] (R-HSA-6806291) CEP290 [specific granule lumen] (R-HSA-6799524) CEP290 [cytosol] (R-HSA-380275)	0.528	3
UniProt:Q86YM7 HOMER1	1	HOMER1 [cytosol] (R-HSA-6794264)	0.527	3
UniProt:P30876 POLR2B	1	POLR2B [nucleoplasm] (R-HSA-63504)	0.527	2
UniProt:O95988 TCL1B			0.527	2
UniProt:Q4VCS5 AMOT			0.527	2
UniProt:Q13426 XRCC4	2	monoSUMO1-K210-XRCC4 [nucleoplasm] (R-HSA-4568892) XRCC4 [nucleoplasm] (R-HSA-75911)	0.527	3
UniProt:Q86YW9 MD12L			0.527	4
UniProt:Q86Y13 DZIP3	1	DZIP3 [cytosol] (R-HSA-976002)	0.527	2
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.527	2
UniProt:O15514 POLR2D	1	POLR2D [nucleoplasm] (R-HSA-63508)	0.527	2
UniProt:P19388 POLR2E	2	POLR2E [cytosol] (R-HSA-1964438) POLR2E [nucleoplasm] (R-HSA-83713)	0.527	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	3
UniProt:Q00403 GTF2B	1	GTF2B [nucleoplasm] (R-HSA-65888)	0.527	2
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.527	2
UniProt:Q15052 ARHGEF6	1	ARHGEF6 [cytosol] (R-HSA-195017)	0.527	3
UniProt:Q9H190 SDCB2			0.488	2
UniProt:Q49A88 CCD14			0.483	4
UniProt:P24928 POLR2A	7	POLR2A [nucleoplasm] (R-HSA-63502) p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-113420) p-3S-POLR2A [nucleoplasm] (R-HSA-6797701) Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-6781855) p-S5(CTD)-POLR2A [nucleoplasm] (R-HSA-77100) p-S5,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6810226) p-S2,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6814543)	0.483	2
UniProt:Q92731 ESR2	5	ESR2 [cytosol] (R-HSA-9020970) ESR2 [nucleoplasm] (R-HSA-446165) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979)	0.462	2

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