Caspase mediated cleavage of vimentin at IDVD (259)

Stable Identifier
R-HSA-350319
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Vimentin is cleaved by several caspases during apoptosis (Morishima et al., 1999, Byun et al., 2001). This clevage disrupts the cytoplasmic network of intermediate filaments and coincides temporally with nuclear fragmentation. Asp259 is recognized and cleaved by caspase-6 (Byun et al., 2001).
Literature References
PubMed ID Title Journal Year
11423904 Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis

Green, KJ, Cryns, VL, Chen, F, Byun, Y, Chang, R, Trivedi, M

Cell Death Differ 2001
Participants
Participates
Catalyst Activity

cysteine-type endopeptidase activity of active caspase-8 [cytosol]

Orthologous Events
Authored
Reviewed
Created
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