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TLN1 [extracellular region]
Stable Identifier
R-HSA-350693
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Talin-1
Icon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Release of platelet cytosolic components (Homo sapiens)
Platelet releasate cytosolic proteins [extracellular region] (Homo sapiens)
TLN1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y490 TLN1
Gene Names
TLN1, KIAA1027, TLN
Chain
chain:1-2541
Reference Genes
BioGPS Gene:7094 TLN1
COSMIC (genes):TLN1 TLN1
CTD Gene:7094 TLN1
dbSNP Gene:7094 TLN1
ENSEMBL:ENSG00000137076 TLN1
HGNC:11845 TLN1
KEGG:hsa:7094 TLN1
Monarch:7094 TLN1
NCBI Gene:7094 TLN1
OMIM:186745 TLN1
UCSC:Q9Y490 TLN1
Reference Transcript
RefSeq:NM_006289.3 TLN1
Other Identifiers
11743123_a_at
11743124_s_at
17093762
203254_PM_s_at
203254_s_at
3204745
3204746
3204747
3204748
3204749
3204750
3204751
3204752
3204753
3204754
3204755
3204756
3204757
3204758
3204759
3204760
3204761
3204763
3204764
3204765
3204766
3204767
3204768
3204769
3204770
3204771
3204772
3204773
3204774
3204775
3204776
3204777
3204780
3204781
3204782
3204783
3204784
3204785
3204786
3204787
3204788
3204789
3204790
3204791
3204792
3204793
3204794
3204796
3204797
3204798
3204799
3204801
3204803
3204806
3204808
3204809
3204810
3204811
3204812
3204813
3204814
3204815
3204817
3204819
3204821
3204827
32166_at
45517_s_at
63588_at
7094
73587_at
8161056
A_23_P9166
A_24_P196851
A_33_P3282898
GE53702
GO:0001726
GO:0001786
GO:0003779
GO:0005178
GO:0005198
GO:0005200
GO:0005515
GO:0005576
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005912
GO:0005925
GO:0007010
GO:0007043
GO:0007044
GO:0007155
GO:0007229
GO:0008092
GO:0008289
GO:0009986
GO:0017166
GO:0030274
GO:0030866
GO:0032587
GO:0033622
GO:0034330
GO:0035091
GO:0042995
GO:0043226
GO:0043622
GO:0045296
GO:0051015
GO:0051893
GO:0065003
GO:0070062
GO:0070161
GO:0070527
GO:0098609
HMNXSV003012266
HMNXSV003023400
ILMN_1696643
PH_hs_0018189
TC09001059.hg
g5454129_3p_s_at
Participates
as a member of
Platelet releasate cytosolic proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
TLN1(434-2541) [cytosol]
TLN1(1-433) [cytosol]
TLN1 [cytosol]
Inferred To
Tln1 [extracellular region]
(Mus musculus)
Tln1 [extracellular region]
(Rattus norvegicus)
tln1 [extracellular region]
(Xenopus tropicalis)
tln-1 [extracellular region]
(Caenorhabditis elegans)
TLN1 [extracellular region]
(Bos taurus)
TLN1 [extracellular region]
(Canis familiaris)
TLN1 [extracellular region]
(Gallus gallus)
TLN1 [extracellular region]
(Sus scrofa)
talB [extracellular region]
(Dictyostelium discoideum)
rhea [extracellular region]
(Drosophila melanogaster)
Cross References
RefSeq
NP_006280.3
ENSEMBL
ENST00000706939
,
ENSP00000316029
,
ENSP00000516659
,
ENST00000314888
OpenTargets
ENSG00000137076
HPA
ENSG00000137076-TLN1
PRO
Q9Y490
Pharos - Targets
Q9Y490
GlyGen
Q9Y490
PDB
4DJ9
,
1SYQ
,
6R9T
,
2MWN
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05106 ITGB3
3
ITGB3 [plasma membrane]
(R-HSA-57600)
ITGB3(27-?) [platelet alpha granule membrane]
(R-HSA-114512)
p-T779-ITGB3 [plasma membrane]
(R-HSA-432107)
0.715
5
UniProt:P07949 RET
2
RET [plasma membrane]
(R-HSA-8853797)
p-5Y-RET [plasma membrane]
(R-HSA-8854162)
0.623
2
UniProt:O60331 PIP5K1C
1
PIP5K1C [cytosol]
(R-HSA-392427)
0.611
8
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.597
5
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.59
2
UniProt:Q2M1Z3 ARHGAP31
1
ARHGAP31 [cytosol]
(R-HSA-195204)
0.59
2
UniProt:P05556 ITGB1
2
ITGB1 [plasma membrane]
(R-HSA-57596)
ITGB1 [endosome membrane]
(R-HSA-9611157)
0.544
2
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.527
2
UniProt:Q5T7N3 KANK4
0.527
3
UniProt:P29084 GTF2E2
1
GTF2E2 [nucleoplasm]
(R-HSA-65563)
0.527
2
UniProt:P53004 BLVRA
1
BLVRA [cytosol]
(R-HSA-189390)
0.527
2
UniProt:Q8WVK2 SNRNP27
1
SNRNP27 [nucleoplasm]
(R-HSA-6806778)
0.527
2
UniProt:P02675 FGB
5
FGB [extracellular region]
(R-HSA-140584)
FGB(31-44) [extracellular region]
(R-HSA-140876)
FGB [plasma membrane]
(R-HSA-140917)
FGB(31-491) [extracellular region]
(R-HSA-140846)
FGB(31-491) [platelet alpha granule lumen]
(R-HSA-140921)
0.527
2
UniProt:P18206 VCL
8
VCL(1-811)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713472)
VCL(1-811)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713480)
VCL(95 kDa) [cytosol]
(R-HSA-9861471)
VCL [ficolin-1-rich granule lumen]
(R-HSA-6800985)
VCL [secretory granule lumen]
(R-HSA-6801010)
VCL [extracellular region]
(R-HSA-350736)
VCL [specific granule lumen]
(R-HSA-6799711)
VCL [cytosol]
(R-HSA-350753)
0.527
2
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