Reactome | TF [secretory granule lumen]

TF [secretory granule lumen]

Stable Identifier

R-HSA-350704

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

Serotransferrin

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P02787 TF

Gene Names

TF, PRO1400

Chain

signal peptide:1-19, chain:20-698

Reference Genes

BioGPS Gene:7018 TF

COSMIC (genes):TF TF

CTD Gene:7018 TF

dbSNP Gene:7018 TF

ENSEMBL:ENSG00000091513 TF

HGNC:11740 TF

KEGG:hsa:7018 TF

Monarch:7018 TF

NCBI Gene:7018 TF

OMIM:190000 TF

UCSC:P02787 TF

Reference Transcript

Participates

as a member of

Platelet releasate secretory granule proteins [secretory granule lumen] (Homo sapiens)

Other forms of this molecule

apoTF [extracellular region]

apoTF [endosome membrane]

TF [endoplasmic reticulum lumen]

p-TF [endoplasmic reticulum lumen]

apoTF [clathrin-coated endocytic vesicle membrane]

Inferred To

tfa [secretory granule lumen] (Danio rerio)

TF [secretory granule lumen] (Bos taurus)

TF [secretory granule lumen] (Gallus gallus)

TF [secretory granule lumen] (Sus scrofa)

Tsf1 [secretory granule lumen] (Drosophila melanogaster)

Tsf2 [secretory granule lumen] (Drosophila melanogaster)

Tsf3 [secretory granule lumen] (Drosophila melanogaster)

Tf [secretory granule lumen] (Mus musculus)

Tf [secretory granule lumen] (Rattus norvegicus)

Homologues of TF [secretory granule lumen] (Drosophila melanogaster)

Cross References

RefSeq

XP_016862579.1, XP_016862578.1, NP_001054.2

OpenTargets

ENSG00000091513

ENSEMBL

ENSG00000091513, ENSP00000385834, ENST00000402696

ZINC - Substances

TRFE_HUMAN

ZINC target

P02787

PRO

P02787

GlyGen

P02787

PDB

6UJ6, 3FGS, 7FFU, 1N84, 1N7W, 5DYH, 6D05, 1OQG, 1BP5, 4X1B, 8BRC, 3S9L, 7Q1L, 6SOZ, 3S9M, 3V89, 9H49, 3QYT, 7FFM, 3VE1, 3V83, 1SUV, 1A8F, 5H52, 1DTG, 1FQF, 1D4N, 1RYO, 1FQE, 3SKP, 6JAS, 6D03, 2O7U, 6CTC, 1N7X, 4X1D, 3V8X, 6D04, 1OQH, 5WTD, 4H0W, 3S9N, 5Y6K, 1D3K, 2O84, 1B3E, 1A8E, 5X5P, 1BTJ, 2HAV, 9H4V, 1JQF, 2HAU, 6SOY

GeneCards

HPA

ENSG00000091513-TF

Pharos - Targets

P02787

Orphanet

HMDB Protein

HMDBP02076

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02786 TFRC	5	TFRC(1-760) [plasma membrane] (R-HSA-917983) TFRC(1-760) [endosome membrane] (R-HSA-8961829) TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869124) TFRC(1-760) [cytoplasmic vesicle membrane] (R-HSA-434196) TFRC(1-760) [Golgi membrane] (R-HSA-434330)	0.852	7
UniProt:A5K736 A5K736			0.733	9
UniProt:Q9K0U9 TBPA			0.632	4
UniProt:Q09057 TBPB1			0.618	3
UniProt:Q9K0V0 TBPB			0.558	2
UniProt:O15173 PGRMC2	4	PGRMC2 [nuclear envelope] (R-HSA-9707674) PGRMC2 [nucleoplasm] (R-HSA-9707859) PGRMC2 [endoplasmic reticulum membrane] (R-HSA-9714349) PGRMC2 [endosome membrane] (R-HSA-9715090)	0.556	3
UniProt:Q7Z5P4 HSD17B13	1	HSD17B13 [cytosol] (R-HSA-8862029)	0.556	3
UniProt:A8MZ59 LEUTX	1	LEUTX [nucleoplasm] (R-HSA-9817277)	0.556	3
UniProt:P08034 GJB1	2	GJB1 [endoplasmic reticulum membrane] (R-HSA-190656) GJB1 [endoplasmic reticulum-Golgi intermediate compartment] (R-HSA-190636)	0.556	3
UniProt:O00501 CLDN5	2	CLDN5 [cell junction] (R-HSA-421264) CLDN5 [plasma membrane] (R-HSA-419991)	0.556	3
UniProt:O43278-2 SPINT1			0.556	3
UniProt:Q8N9I0 SYT2	3	SYT2 [synaptic vesicle membrane] (R-HSA-194786) SYT2 [plasma membrane] (R-HSA-168795) SYT2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869116)	0.556	3
UniProt:Q9GZR5 ELOVL4	1	ELOVL4 [endoplasmic reticulum membrane] (R-HSA-548705)	0.556	3
UniProt:Q7Z7G2 CPLX4			0.556	3
UniProt:Q96TC7 RMD3			0.556	3
UniProt:Q4KMG9 TM52B			0.556	3
UniProt:Q99523 SORT1	2	SORT1 [cytoplasmic vesicle membrane] (R-HSA-434221) SORT1 [Golgi membrane] (R-HSA-434332)	0.556	3
UniProt:Q8TED1 GPX8	1	GPX8 [endoplasmic reticulum lumen] (R-HSA-3341303)	0.556	3
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:Q8NBJ4 GOLM1	2	p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938) GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710)	0.556	3
UniProt:O15529 GPR42			0.556	3
UniProt:O43315 AQP9	1	AQP9 [plasma membrane] (R-HSA-431761)	0.556	3
UniProt:Q96KR6 F210B			0.556	3
UniProt:Q9BXS9-3 SLC26A6			0.556	3
UniProt:Q16659 MAPK6	6	p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665) MAPK6 [nucleoplasm] (R-HSA-5692686) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) p-S189 MAPK6 [cytosol] (R-HSA-5687019) MAPK6 [cytosol] (R-HSA-5686979) ub-MAPK6 [cytosol] (R-HSA-5687000)	0.527	2
UniProt:Q9NQZ2 UTP3	1	UTP3 [nucleoplasm] (R-HSA-6790637)	0.527	2
UniProt:O15232 MATN3	3	MATN3 [extracellular region] (R-HSA-2426297) p-MATN3 [endoplasmic reticulum lumen] (R-HSA-8957026) MATN3 [endoplasmic reticulum lumen] (R-HSA-8956719)	0.527	2
UniProt:Q9H8H2 DDX31			0.527	2
UniProt:Q9H788 SH24A			0.527	2
UniProt:P35219 CAH8			0.527	2
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.527	6
UniProt:Q8N412 STPG2			0.527	2
UniProt:Q9BSW7 SYT17			0.527	2
UniProt:P05091 ALDH2	1	ALDH2 [mitochondrial matrix] (R-HSA-71718)	0.527	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2

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