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CFL1 [cytosol]
Stable Identifier
R-HSA-350751
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Cofilin-1, COF1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
LIMK phosphorylates CFL1, inactivating it (Homo sapiens)
CFL1 [cytosol] (Homo sapiens)
Semaphorin interactions (Homo sapiens)
Sema3A PAK dependent Axon repulsion (Homo sapiens)
Phosphorylation of cofilin by LIMK-1 (Homo sapiens)
CFL1 [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Release of (inferred) platelet cytosolic components (Homo sapiens)
Platelet releasate (inferred) cytosolic proteins [cytosol] (Homo sapiens)
CFL1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-12 signaling (Homo sapiens)
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
Expression of Cofilin-1 (Homo sapiens)
CFL1 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
Phosphorylation of cofilin by LIMK-1 (Homo sapiens)
CFL1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate ROCKs (Homo sapiens)
LIMK phosphorylates CFL1, inactivating it (Homo sapiens)
CFL1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23528 CFL1
Gene Names
CFL1, Cofilin-1, CFL
Chain
initiator methionine:, chain:2-166
Reference Genes
BioGPS Gene:1072 CFL1
COSMIC (genes):CFL1 CFL1
CTD Gene:1072 CFL1
dbSNP Gene:1072 CFL1
ENSEMBL:ENSG00000172757 CFL1
ENSEMBL_homo_sapiens_GENE:ENSG00000172757.13 CFL1
HGNC:1874 CFL1
KEGG Gene (Homo sapiens):1072 CFL1
Monarch:1072 CFL1
NCBI Gene:1072 CFL1
OMIM:601442 CFL1
Reference Transcript
RefSeq:NM_005507.2 CFL1
Other Identifiers
1072
11753645_a_at
11753646_x_at
11754158_a_at
11757818_x_at
11763259_x_at
1555730_PM_a_at
1555730_a_at
16654211
16654213
16654215
16654217
16654233
16654235
16654237
16654239
16654241
16654243
18671394
18671395
18671397
18671403
18671404
18671405
200021_PM_at
200021_at
33659_at
3377891
3377892
3377893
3377894
3377895
3377897
3377899
3377902
75185_f_at
7892701
7894264
7895149
7895299
7895945
7896038
7949496
GE79937
GO:0000278
GO:0000281
GO:0000910
GO:0003779
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0007010
GO:0007266
GO:0008092
GO:0009615
GO:0012501
GO:0015629
GO:0016020
GO:0016363
GO:0022604
GO:0023052
GO:0030027
GO:0030036
GO:0030042
GO:0030043
GO:0030154
GO:0030424
GO:0030426
GO:0031258
GO:0031982
GO:0032587
GO:0034330
GO:0040019
GO:0042995
GO:0043066
GO:0043226
GO:0044794
GO:0048856
GO:0051014
GO:0051015
GO:0051293
GO:0061001
GO:0070062
HMNXSV003014976
Hs2.180370.2.S1_3p_s_at
ILMN_1705617
TC11001945.hg
X95404_at
g5031634_3p_at
g5031634_3p_x_at
Participates
as an output of
Expression of Cofilin-1 (Homo sapiens)
as a member of
Platelet releasate (inferred) cytosolic proteins [cytosol] (Homo sapiens)
as an input of
LIMK phosphorylates CFL1, inactivating it (Homo sapiens)
Phosphorylation of cofilin by LIMK-1 (Homo sapiens)
Other forms of this molecule
p-S3-CFL1 [cytosol]
CFL1 [extracellular region]
Cross References
RefSeq
NP_005498.1
OpenTargets
ENSG00000172757
GeneCards
P23528
HPA
ENSG00000172757-CFL1
Ensembl
ENSP00000309629
,
ENSG00000172757
,
ENST00000525451
,
ENST00000308162
,
ENSP00000432660
PRO
P23528
Pharos - Targets
P23528
PDB
6UC4
,
5HVK
,
1Q8G
,
4BEX
,
6UBY
,
1Q8X
,
6VAO
,
5L6W
,
3J0S
,
6UC0
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60709 ACTB
5
Unfolded ACTB [cytosol]
(R-HSA-390462)
ACTB [nucleoplasm]
(R-HSA-3321990)
ACTB [cytosol]
(R-HSA-201861)
ACTB [lysosomal membrane]
(R-HSA-196160)
ACTB [plasma membrane]
(R-HSA-196016)
0.933
11
UniProt:P63261 ACTG1
3
ACTG1 [cytosol]
(R-HSA-201858)
ACTG1 [lysosomal membrane]
(R-HSA-196169)
ACTG1 [plasma membrane]
(R-HSA-196044)
0.831
10
UniProt:P53667 LIMK1
3
p-S,T508-LIMK1 [cytosol]
(R-HSA-419610)
p-T508-LIMK1 [cytosol]
(R-HSA-399816)
LIMK1 [cytosol]
(R-HSA-397785)
0.722
3
UniProt:P54253 ATX1
0.703
11
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.668
3
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.656
3
UniProt:P40123 CAP2
1
CAP2 [cytosol]
(R-HSA-428863)
0.643
4
UniProt:P32121 ARRB2
3
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [endocytic vesicle membrane]
(R-HSA-9910881)
0.577
4
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.577
3
UniProt:Q13393 PLD1
4
PLD1 [endoplasmic reticulum membrane]
(R-HSA-1498795)
PLD1 [plasma membrane]
(R-HSA-2028998)
PLD1 [tertiary granule membrane]
(R-HSA-6800955)
PLD1 [specific granule membrane]
(R-HSA-6799531)
0.571
4
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.569
10
UniProt:P68032 ACTC1
1
ACTC1 [cytosol]
(R-HSA-390536)
0.564
2
UniProt:Q96CV9 OPTN
6
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [cytosol]
(R-HSA-9687907)
p-S177,S473,S513-OPTN [cytosol]
(R-HSA-9687840)
0.556
3
UniProt:Q549N0 Q549N0
0.556
3
UniProt:Q1KLZ0 Q1KLZ0
0.556
3
UniProt:Q15303 ERBB4
0.553
2
UniProt:Q9Y281 COF2
0.547
3
UniProt:O14939 PLD2
2
PLD2 [plasma membrane]
(R-HSA-2029075)
PLD2 [endoplasmic reticulum membrane]
(R-HSA-1498791)
0.544
2
UniProt:P57058 HUNK
0.524
2
UniProt:P0DOE7 M
5
p-S95,T205-M [cytosol]
(R-RSY-9831678)
p-S95,T205-M [nucleoplasm]
(R-RSY-9831706)
M [nucleoplasm]
(R-RSY-9831711)
Nascent M [cytosol]
(R-RSY-9828672)
p-S95,T205-M [viral tegument]
(R-RSY-9836531)
0.524
2
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.499
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
12
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE
0.462
2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.462
2
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