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Caspase-3 [cytosol]
Stable Identifier
R-HSA-350870
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
2x(CASP3(29-175):CASP3(176-277))
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
E-cadherin degradation by caspase-3 and calpain-1 (Homo sapiens)
Active caspase-3 heterotetramer, calpain-1 [cytosol] (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Other interleukin signaling (Homo sapiens)
Caspase-3 cleaves pro-interleukin-16 (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptosis induced DNA fragmentation (Homo sapiens)
Translocation of caspase-3 to the nucleus (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Apoptotic cleavage of cellular proteins (Homo sapiens)
Apoptotic cleavage of cell adhesion proteins (Homo sapiens)
Caspase mediated cleavage of beta-catenin (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase-mediated cleavage of Desmoglein 1 (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase-mediated cleavage of Desmoglein 2 (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase-mediated cleavage of Desmoglein 3 (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase-mediated cleavage of Desmoplakin (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase-mediated cleavage of E-Cadherin (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase-mediated cleavage of TJP1 (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase-mediated cleavage of Z0-2 (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase-mediated cleavage of occludin (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase-mediated cleavage of plakophilin-1 (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase 3-mediated cleavage of PKC delta (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase mediated cleavage of APC (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase mediated cleavage of C-IAP1 (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase-mediated cleavage of Acinus (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase-mediated cleavage of Etk (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase-mediated cleavage of MASK (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase-mediated cleavage of MST3 (Homo sapiens)
Caspase-3, Caspase-7 [cytosol] (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase-mediated cleavage of PKC theta (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase-mediated cleavage of Rock-1 (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase-mediated cleavage of cytoskeletal proteins (Homo sapiens)
Caspase mediated cleavage of HIP-55 (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase mediated cleavage of alpha-II-Fodrin (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase-mediated cleavage of GAS2 (Homo sapiens)
Caspase-3, Caspase-7 [cytosol] (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase-mediated cleavage of Tau (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase-mediated cleavage of alpha adducin (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase-mediated cleavage of gelsolin (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase-mediated cleavage of vimentin at DSVD (85) (Homo sapiens)
Caspase-3, Caspase-7 [cytosol] (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Stimulation of the cell death response by PAK-2p34 (Homo sapiens)
Cleavage of PAK-2 at 212 (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
Caspase activation via Dependence Receptors in the absence of ligand (Homo sapiens)
Activation of caspase-3 (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase cleavage of DCC (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase cleavage of UNC5A (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Caspase cleavage of UNC5B (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Apoptotic factor-mediated response (Homo sapiens)
Cytochrome c-mediated apoptotic response (Homo sapiens)
Activation of caspases through apoptosome-mediated cleavage (Homo sapiens)
Cleavage of Procaspase-3 by the apoptosome (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
SMAC, XIAP-regulated apoptotic response (Homo sapiens)
SMAC (DIABLO) binds to IAPs (Homo sapiens)
SMAC binds XIAP:Caspase-3 (Homo sapiens)
DIABLO:XIAP:Caspase-3 [cytosol] (Homo sapiens)
XIAP:Caspase-3 [cytosol] (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
XIAP:Caspase-3 [cytosol] (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes (Homo sapiens)
Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
DIABLO:XIAP:Caspase-3 [cytosol] (Homo sapiens)
XIAP:Caspase-3 [cytosol] (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
XIAP binds CASP3 (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
DIABLO:XIAP:Caspase-3 [cytosol] (Homo sapiens)
XIAP:Caspase-3 [cytosol] (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
XIAP:Caspase-3 [cytosol] (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Regulated Necrosis (Homo sapiens)
Pyroptosis (Homo sapiens)
CASP1 cleaves GSDMD (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
CASP3 cleaves GSDMD (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
CASP3 cleaves GSDME (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
CASP4, CASP5 cleave GSDMD (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NADE modulates death signalling (Homo sapiens)
p75NTR:NADE promotes caspase2/3 activation (Homo sapiens)
Active Caspases 2, 3 [cytosol] (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Signaling by Hippo (Homo sapiens)
Cleavage of p-STK3 (p-MST2) by caspase 3 (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Cleavage of p-STK4 (p-MST1) by caspase 3 (Homo sapiens)
Caspase-3 [cytosol] (Homo sapiens)
Participants
components
x 2
CASP3(29-175):CASP3(176-277) [cytosol]
(Homo sapiens)
Participates
as a member of
Active caspase-3 heterotetramer, calpain-1 [cytosol] (Homo sapiens)
Active Caspases 2, 3 [cytosol] (Homo sapiens)
Caspase-3, Caspase-7 [cytosol] (Homo sapiens)
as an input of
XIAP binds CASP3 (Homo sapiens)
Translocation of caspase-3 to the nucleus (Homo sapiens)
as an output of
Cleavage of Procaspase-3 by the apoptosome (Homo sapiens)
Activation of caspase-3 (Homo sapiens)
Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 (Homo sapiens)
as a component of
XIAP:Caspase-3 [cytosol] (Homo sapiens)
This entity regulates
Negatively
CASP4, CASP5 cleave GSDMD
(Homo sapiens)
CASP1 cleaves GSDMD
(Homo sapiens)
Inferred To
Caspase-3 tetramer [cytosol]
(Mus musculus)
Caspase-3 [cytosol]
(Bos taurus)
Caspase-3 [cytosol]
(Caenorhabditis elegans)
Caspase-3 [cytosol]
(Canis familiaris)
Caspase-3 [cytosol]
(Danio rerio)
Caspase-3 [cytosol]
(Drosophila melanogaster)
Caspase-3 [cytosol]
(Gallus gallus)
Caspase-3 [cytosol]
(Rattus norvegicus)
Caspase-3 [cytosol]
(Sus scrofa)
Caspase-3 [cytosol]
(Xenopus tropicalis)
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