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AP1B1 [cytoplasmic vesicle membrane]
Stable Identifier
R-HSA-351181
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane
Synonyms
AP-1 beta subunit
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
trans-Golgi Network Vesicle Budding (Homo sapiens)
Golgi Associated Vesicle Biogenesis (Homo sapiens)
trans-Golgi Network Derived Vesicle Uncoating (Homo sapiens)
Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex [cytoplasmic vesicle membrane] (Homo sapiens)
AP-1 Complex [cytoplasmic vesicle membrane] (Homo sapiens)
AP1B1 [cytoplasmic vesicle membrane] (Homo sapiens)
trans-Golgi Network Vesicle Scission (Homo sapiens)
Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex [cytoplasmic vesicle membrane] (Homo sapiens)
AP-1 Complex [cytoplasmic vesicle membrane] (Homo sapiens)
AP1B1 [cytoplasmic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q10567 AP1B1
Gene Names
AP1B1, ADTB1, BAM22, CLAPB2
Chain
chain:1-949
Reference Genes
BioGPS Gene:162 AP1B1
COSMIC (genes):AP1B1 AP1B1
CTD Gene:162 AP1B1
dbSNP Gene:162 AP1B1
ENSEMBL:ENSG00000100280 AP1B1
ENSEMBL_homo_sapiens_GENE:ENSG00000100280.17 AP1B1
HGNC:554 AP1B1
KEGG Gene (Homo sapiens):162 AP1B1
Monarch:162 AP1B1
NCBI Gene:162 AP1B1
OMIM:600157 AP1B1
UCSC:Q10567 AP1B1
Reference Transcript
RefSeq:NM_145730.2 AP1B1
RefSeq:NM_001166019.1 AP1B1
RefSeq:NM_001127.3 AP1B1
Other Identifiers
11730427_a_at
11730428_a_at
162
16933591
205423_PM_at
205423_at
3956782
3956783
3956784
3956785
3956788
3956791
3956792
3956793
3956795
3956796
3956798
3956799
3956800
3956801
3956803
3956804
3956805
3956807
3956808
3956810
3956811
3956812
3956814
3956815
3956816
3956817
3956823
3956824
3956829
3956831
40745_at
8075217
A_23_P6398
A_33_P3317593
GE57637
GO:0000139
GO:0001822
GO:0005515
GO:0005764
GO:0005765
GO:0005768
GO:0005769
GO:0005773
GO:0005794
GO:0005829
GO:0006886
GO:0007368
GO:0007507
GO:0015031
GO:0016020
GO:0016192
GO:0019901
GO:0030117
GO:0030121
GO:0030131
GO:0030276
GO:0030659
GO:0030665
GO:0031090
GO:0031410
GO:0032588
GO:0043226
GO:0043231
GO:0048856
GO:0060155
GO:0110010
GO:1903232
HMNXSV003020318
ILMN_1781983
ILMN_2387505
L13939_s_at
PH_hs_0016268
TC22000634.hg
g4501972_3p_at
Participates
as a component of
AP-1 Complex [cytoplasmic vesicle membrane] (Homo sapiens)
Other forms of this molecule
AP1B1 [Golgi membrane]
AP1B1 [lysosomal membrane]
AP1B1 [trans-Golgi network membrane]
AP1B1 [cytosol]
Inferred To
AP1B1 [cytoplasmic vesicle membrane]
(Bos taurus)
AP1B1 [cytoplasmic vesicle membrane]
(Canis familiaris)
AP1B1 [cytoplasmic vesicle membrane]
(Gallus gallus)
AP1B1 [cytoplasmic vesicle membrane]
(Sus scrofa)
Ap1b1 [cytoplasmic vesicle membrane]
(Mus musculus)
Ap1b1 [cytoplasmic vesicle membrane]
(Rattus norvegicus)
APL2 [cytoplasmic vesicle membrane]
(Saccharomyces cerevisiae)
apb-1 [cytoplasmic vesicle membrane]
(Caenorhabditis elegans)
AP-1-2beta [cytoplasmic vesicle membrane]
(Drosophila melanogaster)
ap1b1 [cytoplasmic vesicle membrane]
(Dictyostelium discoideum)
ap1b1 [cytoplasmic vesicle membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_663782.2
,
NP_001159491.1
,
NP_001118.3
OpenTargets
ENSG00000100280
HPA
ENSG00000100280-AP1B1
GeneCards
Q10567
Ensembl
ENST00000317368
,
ENSP00000319361
,
ENST00000357586
,
ENSP00000350199
,
ENSG00000100280
,
ENSP00000400065
,
ENST00000405198
,
ENSP00000384194
,
ENST00000432560
PRO
Q10567
Pharos - Targets
Q10567
Orphanet
28822
PDB
6D83
,
8D4E
,
8D9S
,
4HMY
,
8D4F
,
6D84
,
8D9W
,
7R4H
,
8D9R
,
6CM9
,
8D9V
,
4P6Z
,
8D4G
,
6DFF
,
8D4C
,
8D4D
,
8D9U
,
6CRI
,
7UX3
,
8D9T
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.649
4
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
13
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
4
UniProt:P42566 EPS15
2
p-Y849 EPS15 [cytosol]
(R-HSA-8867028)
EPS15 [cytosol]
(R-HSA-182920)
0.527
2
UniProt:P49757 NUMB
1
NUMB [plasma membrane]
(R-HSA-443595)
0.527
4
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.527
4
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