Spermidine => N-acetylated spermidine

Stable Identifier
R-HSA-351208
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
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Spermidine/spermine N1-acetyltransferase (Spd/Spm acetyltransferase) is the rate-limiting enzyme in the catabolism of polyamines. Defects in SAT1 may be the cause of keratosis follicularis spinulosa decalvans (KFSD).
Literature References
PubMed ID Title Journal Year
8360194 Polyamine and polyamine analog regulation of spermidine/spermine N1-acetyltransferase in MALME-3M human melanoma cells

Shappell, NW, Fogel-Petrovic, M, Bergeron, RJ, Porter, CW

J Biol Chem 1993
1985966 Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase

Casero RA, Jr, Applegren, NB, Pegg, AE, Ervin, SJ, Wiest, L, Celano, P

J Biol Chem 1991
Participants
Participates
Catalyst Activity

diamine N-acetyltransferase activity of SAT1 [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
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