Reactome | HSPA5 [endoplasmic reticulum membrane]

HSPA5 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-351315

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

78 kDa glucose-regulated protein, BiP, GRP78

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Locations in the PathwayBrowser for interactor UniProt:P14625 HSP90B1

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External Reference Information

External Reference

UniProt:P11021 HSPA5

Gene Names

HSPA5, GRP78

Chain

signal peptide:1-18, chain:19-654

Reference Genes

BioGPS Gene:3309 HSPA5

COSMIC (genes):HSPA5 HSPA5

CTD Gene:3309 HSPA5

dbSNP Gene:3309 HSPA5

ENSEMBL:ENSG00000044574 HSPA5

HGNC:5238 HSPA5

KEGG:hsa:3309 HSPA5

Monarch:3309 HSPA5

NCBI Gene:3309 HSPA5

OMIM:138120 HSPA5

UCSC:P11021 HSPA5

Reference Transcript

RefSeq:NM_005347.4 HSPA5

Other Identifiers

11725930_s_at

11725931_at

11725932_a_at

11725933_at

11725934_x_at

11758169_s_at

17098411

211936_PM_at

211936_at

230031_PM_at

230031_at

2331066

2331070

2331074

2331076

2331077

2750337

2750344

2750345

2750346

3225399

3225400

3225401

3225402

3225403

3225404

3225405

3225406

3225407

3225408

3225409

3225410

3225411

3225412

3225413

3225414

3225415

3225416

3225417

3225418

3225419

3225420

3309

36614_at

47634_at

8164165

A_24_P18190

A_24_P98411

GE86936

GO:0003824

GO:0005509

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005739

GO:0005783

GO:0005788

GO:0005789

GO:0005793

GO:0005829

GO:0005886

GO:0005925

GO:0006355

GO:0006457

GO:0006886

GO:0006983

GO:0008180

GO:0009986

GO:0016020

GO:0016787

GO:0016887

GO:0019899

GO:0019904

GO:0021589

GO:0021680

GO:0021762

GO:0030163

GO:0030335

GO:0030496

GO:0030512

GO:0030968

GO:0031072

GO:0031204

GO:0031333

GO:0031398

GO:0031410

GO:0031625

GO:0032991

GO:0034663

GO:0034975

GO:0034976

GO:0035437

GO:0036503

GO:0042026

GO:0042149

GO:0042470

GO:0043022

GO:0043066

GO:0043226

GO:0043231

GO:0044183

GO:0045296

GO:0045944

GO:0048856

GO:0051082

GO:0051085

GO:0051087

GO:0051603

GO:0051787

GO:0055085

GO:0060904

GO:0070062

GO:0071353

GO:0140657

GO:0140662

GO:1903891

GO:1903894

GO:1903895

GO:1903897

HMNXSV003037349

Hs.75410.1.S1_3p_at

Hs.75410.4.A1_3p_at

ILMN_1773865

M19645_at

PH_hs_0023711

TC09001589.hg

Participates

as an input of

Release of 78 kDa glucose-regulated protein (Homo sapiens)

as an output of

Expression of BIP (78 kDa Glucose-regulated protein, GRP78, HSPA5) (Homo sapiens)

as a component of

Other forms of this molecule

HSPA5 [lumenal side of endoplasmic reticulum membrane]

HSPA5 [nucleoplasm]

HSPA5 [cytosol]

HSPA5 [endoplasmic reticulum lumen]

HSPA5 [extracellular region]

Inferred To

hsp-3 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

hspa5 [endoplasmic reticulum membrane] (Xenopus tropicalis)

HSPA5 [endoplasmic reticulum membrane] (Bos taurus)

HSPA5 [endoplasmic reticulum membrane] (Canis familiaris)

HSPA5 [endoplasmic reticulum membrane] (Drosophila melanogaster)

HSPA5 [endoplasmic reticulum membrane] (Gallus gallus)

HSPA5 [endoplasmic reticulum membrane] (Mus musculus)

HSPA5 [endoplasmic reticulum membrane] (Rattus norvegicus)

HSPA5 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

HSPA5 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

HSPA5 [endoplasmic reticulum membrane] (Sus scrofa)

bip2 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

Cross References

RefSeq

NP_005338.1

Guide to Pharmacology - Targets

3193

OpenTargets

ENSG00000044574

ENSEMBL

ENST00000324460, ENSP00000324173

ZINC - Substances

GRP78_HUMAN

ZINC - Biogenic

GRP78_HUMAN

ZINC target

P11021

PRO

P11021

GlyGen

P11021

PDB

5EVZ, 6DFM, 5E86, 5EXW, 6ZMD, 6CZ1, 5E85, 5F1X, 5F0X, 3LDO, 7N1R, 5EX5, 3LDP, 5E84, 6DFO, 5EY4, 5F2R, 6ASY, 3LDN, 6DO2, 6DWS, 3IUC, 3LDL

ZINC - Metabolites

GRP78_HUMAN

IntEnz

3.6.4.10

HPA

ENSG00000044574-HSPA5

Pharos - Targets

P11021

ZINC - Predictions - Purchasable

GRP78_HUMAN

Interactors (106)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UBS4 DNAJB11	1	DNAJB11 [endoplasmic reticulum lumen] (R-HSA-381040)	0.829	5
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.774	25
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9694638) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) fully glycosylated Spike [virion membrane] (R-COV-9698327) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997)	0.746	8
UniProt:Q9H173 SIL1			0.744	10
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.742	5
UniProt:Q9BYF1 ACE2	5	glycosylated-ACE2 [plasma membrane] (R-HSA-9683480) ACE2 [endocytic vesicle membrane] (R-HSA-9698958) glycosylated-ACE2 [endocytic vesicle membrane] (R-HSA-9686721) ACE2 [endoplasmic reticulum lumen] (R-HSA-9683474) ACE2(18-805) [plasma membrane] (R-HSA-2022344)	0.722	6
ChEBI:132781 HA15			0.687	8
UniProt:Q9Y4L1 HYOU1	3	HYOU1 [endoplasmic reticulum lumen] (R-HSA-535542) HYOU1 [endocytic vesicle lumen] (R-HSA-3221924) HYOU1 [extracellular region] (R-HSA-3221939)	0.669	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.666	6
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.659	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.659	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.643	7
UniProt:O94905 ERLIN2	3	EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-FGFR1(1-822) [plasma membrane] (R-HSA-8853148) EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-p-8Y-FGFR1(1-822) [plasma membrane] (R-HSA-8853122) ERLIN2 [endoplasmic reticulum membrane] (R-HSA-8866520)	0.643	3
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.638	4
UniProt:P36955 PEDF			0.623	3
UniProt:Q92874 DNSL2			0.623	3
UniProt:O75460-1 ERN1			0.612	4
UniProt:Q6E0U4 DMKN	1	DMKN [secretory granule lumen] (R-HSA-9839542)	0.602	3
UniProt:Q9NZJ5 EIF2AK3	3	EIF2AK3 [endoplasmic reticulum membrane] (R-HSA-381046) EIF2AK3(30-144)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713456) EIF2AK3(30-144)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713454)	0.589	4
UniProt:Q96IZ0 PAWR			0.581	8
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.576	5
UniProt:Q62627 PAWR			0.576	4
UniProt:P29322 EPHA8	2	EPHA8 [plasma membrane] (R-HSA-2682321) p-Y610,Y616-EPHA8 [plasma membrane] (R-HSA-3928350)	0.569	3
UniProt:P14625 HSP90B1	4	HSP90B1 [endocytic vesicle lumen] (R-HSA-3221623) HSP90B1 [extracellular region] (R-HSA-3221653) p-HSP90B1 [endoplasmic reticulum lumen] (R-HSA-8957016) HSP90B1 [endoplasmic reticulum lumen] (R-HSA-981545)	0.564	2
UniProt:P09544 WNT2	9	WNT2 [extracellular region] (R-HSA-201690) N4GlycoAsn-PalmS WNT2 [extracellular exosome] (R-HSA-3781947) N4GlycoAsn-PalmS WNT2 [endocytic vesicle membrane] (R-HSA-3781972) WNT2 [endoplasmic reticulum lumen] (R-HSA-3238284) N4GlycoAsn-WNT2 [endoplasmic reticulum lumen] (R-HSA-3238226) N4GlycoAsn-PalmS WNT2 [endoplasmic reticulum lumen] (R-HSA-3238340) N4GlycoAsn-PalmS WNT2 [Golgi lumen] (R-HSA-3247819) N4GlycoAsn-PalmS WNT2 [extracellular region] (R-HSA-3247825) N4GlycoAsn-PalmS WNT2 [plasma membrane] (R-HSA-3247827)	0.564	2
UniProt:Q15084 PDIA6	3	PDIA6 [endoplasmic reticulum lumen] (R-HSA-3009049) p-PDIA6 [endoplasmic reticulum lumen] (R-HSA-8957031) PDIA6 [endoplasmic reticulum membrane] (R-HSA-535530)	0.564	2
UniProt:P49184 DNASE1L1	2	DNASE1L1 [extracellular region] (R-HSA-6806320) DNASE1L1 [specific granule lumen] (R-HSA-6799554)	0.564	3
UniProt:Q9Y328 NSG2			0.564	2
UniProt:P61619 SEC61A1	2	SEC61A1 [endoplasmic reticulum membrane] (R-HSA-444591) SEC61A1 [phagocytic vesicle membrane] (R-HSA-1236813)	0.558	3
UniProt:Q15486 GUSP1			0.556	3
UniProt:Q6PF05 TT23L			0.556	3
UniProt:Q9ULD4-2 Q9ULD42			0.556	3
UniProt:Q13404 UBE2V1	1	UBE2V1 [cytosol] (R-HSA-205753)	0.556	3
UniProt:Q9UHI5 SLC7A8	1	SLC7A8 [plasma membrane] (R-HSA-352156)	0.556	3
UniProt:Q91YW3	5	Dnajc3 [extracellular region] (R-MMU-6806239) Dnajc3 [azurophil granule lumen] (R-MMU-6799146) Dnajc3 [cytosol] (R-MMU-448199) phospho-Dnajc3 [endoplasmic reticulum lumen] (R-MMU-8956975) Dnajc3 [endoplasmic reticulum lumen] (R-MMU-448201)	0.544	2
UniProt:P58166 INHBE	1	INHBE [extracellular region] (R-HSA-1449700)	0.527	2
UniProt:Q9BTY2 FUCA2	4	FUCA2 [extracellular region] (R-HSA-6806227) FUCA2 [azurophil granule lumen] (R-HSA-6798772) p-FUCA2 [endoplasmic reticulum lumen] (R-HSA-8957005) FUCA2 [endoplasmic reticulum lumen] (R-HSA-8956727)	0.527	2
UniProt:P13497 BMP1	1	BMP1 [extracellular region] (R-HSA-2002393)	0.527	2
UniProt:P05111 INHA	1	INHA [extracellular region] (R-HSA-1449702)	0.527	2
UniProt:O60513 B4GALT4	1	B4GALT4 [Golgi membrane] (R-HSA-975911)	0.527	2
UniProt:Q77M19 Q77M19			0.527	2
UniProt:P0DPA2 VSIG8			0.527	2
UniProt:Q6XE38 SG1D4			0.527	2
UniProt:Q96DN2 VWCE			0.527	2
UniProt:P56705 WNT4	9	WNT4 [extracellular region] (R-HSA-517385) N4GlycoAsn-PalmS WNT4 [extracellular exosome] (R-HSA-3781964) N4GlycoAsn-PalmS WNT4 [endocytic vesicle membrane] (R-HSA-3781978) WNT4 [endoplasmic reticulum lumen] (R-HSA-3238297) N4GlycoAsn-WNT4 [endoplasmic reticulum lumen] (R-HSA-3238235) N4GlycoAsn-PalmS WNT4 [endoplasmic reticulum lumen] (R-HSA-3238347) N4GlycoAsn-PalmS WNT4 [Golgi lumen] (R-HSA-3247779) N4GlycoAsn-PalmS WNT4 [extracellular region] (R-HSA-3247794) N4GlycoAsn-PalmS WNT4 [plasma membrane] (R-HSA-3247809)	0.527	3
UniProt:Q86YC3 LRC33			0.527	2
UniProt:Q8NG41 NPB	2	NPB(25-48) [extracellular region] (R-HSA-374794) NPB(25-53) [extracellular region] (R-HSA-374790)	0.527	2
UniProt:O95968 SG1D1			0.527	3
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.527	2
UniProt:Q8IV13 CCNJL			0.527	4
UniProt:P07307 ASGR2	1	PALM-C54,58-ASGR2 [plasma membrane] (R-HSA-8855706)	0.527	2
UniProt:Q92598 HSPH1	3	HSPH1 [cytosol] (R-HSA-3299412) HSPH1 [endocytic vesicle lumen] (R-HSA-3221904) HSPH1 [extracellular region] (R-HSA-3221883)	0.527	2
UniProt:Q96S86 HPLN3			0.527	2
UniProt:P49286 MTNR1B	1	MTNR1B [plasma membrane] (R-HSA-419349)	0.527	2
UniProt:O96009 NAPSA	1	NAPSA [multivesicular body lumen] (R-HSA-5684975)	0.527	2
UniProt:Q9UKU9 ANGL2			0.527	2
UniProt:Q14392 LRC32			0.527	2
UniProt:Q17R55 F187B			0.527	2
UniProt:Q9H6X2 ANTXR1			0.527	3
UniProt:Q7Z4N8 P4HA3	1	P4HA3 [endoplasmic reticulum lumen] (R-HSA-2980915)	0.527	2
UniProt:Q99592 ZBT18			0.527	2
UniProt:P01222 TSHB	1	TSHB [extracellular region] (R-HSA-378957)	0.527	2
UniProt:Q8IW92 GLB1L2	1	GLB1L2 [lysosomal lumen] (R-HSA-9840308)	0.527	2
UniProt:P48039 MTNR1A	1	MTNR1A [plasma membrane] (R-HSA-419316)	0.527	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.527	5
UniProt:Q6NSJ0 MYORG			0.527	2
UniProt:Q16842 ST3GAL2	1	ST3GAL2 [Golgi membrane] (R-HSA-981482)	0.527	2
UniProt:A5D8T8 CL18A			0.527	2
UniProt:Q96PQ1 SIGLEC12	1	SIGLEC12 [plasma membrane] (R-HSA-197729)	0.527	2
UniProt:P48052 CPA2	1	pro-CPA2 [zymogen granule] (R-HSA-9922737)	0.527	2
UniProt:Q8WWA0 ITLN1	1	ITLN1 [extracellular region] (R-HSA-6804515)	0.527	4
UniProt:Q8TE60 ADAMTS18	4	ADAMTS18 [extracellular region] (R-HSA-3791290) ADAMTS18 [endoplasmic reticulum lumen] (R-HSA-5173116) glc-fuc-ADAMTS18 [endoplasmic reticulum lumen] (R-HSA-5173291) O-fuc-ADAMTS18 [endoplasmic reticulum lumen] (R-HSA-5173143)	0.527	2
UniProt:Q6UXI7 VITRN			0.527	2
UniProt:O00755 WNT7A	9	WNT7A [extracellular region] (R-HSA-517404) N4GlycoAsn-PalmS WNT7A [extracellular exosome] (R-HSA-3781951) N4GlycoAsn-PalmS WNT7A [endocytic vesicle membrane] (R-HSA-3781961) WNT7A [endoplasmic reticulum lumen] (R-HSA-3238312) N4GlycoAsn-WNT7A [endoplasmic reticulum lumen] (R-HSA-3238249) N4GlycoAsn-PalmS WNT7A [endoplasmic reticulum lumen] (R-HSA-3238354) N4GlycoAsn-PalmS WNT7A [Golgi lumen] (R-HSA-3247778) N4GlycoAsn-PalmS WNT7A [extracellular region] (R-HSA-3247774) N4GlycoAsn-PalmS WNT7A [plasma membrane] (R-HSA-3247833)	0.527	2
UniProt:Q8IXA5 SACA3			0.527	2
UniProt:Q07954 LRP1	2	LRP1 [endocytic vesicle membrane] (R-HSA-2230981) LRP1 [plasma membrane] (R-HSA-1454844)	0.527	2
UniProt:Q5FYB1 ARSI	2	OxA-ARSI [endoplasmic reticulum lumen] (R-HSA-1614360) ARSI [endoplasmic reticulum lumen] (R-HSA-1609671)	0.527	2
UniProt:Q9Y581 INSL6			0.527	2
UniProt:Q9HD89 RETN	3	RETN [azurophil granule lumen] (R-HSA-6799357) RETN [extracellular region] (R-HSA-6806172) RETN [specific granule lumen] (R-HSA-6799355)	0.527	2
UniProt:Q9UI38 TSP50			0.527	3
UniProt:O43323 DHH	10	CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [extracellular region] (R-HSA-445155) CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [plasma membrane] (R-HSA-5362420) CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [endoplasmic reticulum lumen] (R-HSA-5362442) ub-N4glycoAsn-DHH(199-396) [endoplasmic reticulum lumen] (R-HSA-5362411) ub-N4glycoAsn-DHH(199-396) [cytosol] (R-HSA-5362368) 2xHC-DHH(23-396) [endoplasmic reticulum lumen] (R-HSA-5358275) N4glycoAsn-DHH(199-396) [endoplasmic reticulum lumen] (R-HSA-5358287) CHOL-DHH(23-198) [endoplasmic reticulum lumen] (R-HSA-5358291) N4glycoAsn-2xHC-DHH(23-396) [endoplasmic reticulum lumen] (R-HSA-5362388) DHH(33-?) [extracellular region] (R-HSA-5362781)	0.527	2
UniProt:O95757 HSPA4L	2	HSPA4L [cytosol] (R-HSA-5251943) HSPA4L [nucleoplasm] (R-HSA-5252053)	0.527	2
UniProt:P07478 PRSS2	2	PRSS2 [azurophil granule lumen] (R-HSA-6799229) PRSS2(24-247) [extracellular region] (R-HSA-1460243)	0.527	2
UniProt:Q9H4B8 DPEP3			0.527	2
UniProt:Q8WXQ8 CBPA5			0.527	2
UniProt:P01019 AGT	7	AGT(36-41) [extracellular region] (R-HSA-2022355) AGT(35-41) [extracellular region] (R-HSA-2022354) AGT(34-40) [extracellular region] (R-HSA-2022351) AGT(34-42) [extracellular region] (R-HSA-2022348) AGT [extracellular region] (R-HSA-1998759) AGT(34-43) [extracellular region] (R-HSA-2022346) AGT(34-41) [extracellular region] (R-HSA-374187)	0.527	2
UniProt:P25685 DNAJB1	3	DNAJB1 [nucleoplasm] (R-HSA-5082366) DNAJB1 [cytosol] (R-HSA-3299666) p-S149,S151,S171 DNAJB1 [cytosol] (R-HSA-5690241)	0.527	2
UniProt:Q13043 STK4	4	STK4(1-487) [cytosol] (R-HSA-201627) STK4(327-487) [cytosol] (R-HSA-2028668) p-T183-STK4(1-487) [cytosol] (R-HSA-2028258) p-T183-STK4(1-326) [cytosol] (R-HSA-2028682)	0.527	3
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	3
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.527	2
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.527	3
UniProt:Q6T424 Q6T424			0.525	3
UniProt:K0BRG7 K0BRG7			0.524	9
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.508	3
UniProt:O95868 LY6G6D	2	cleaved GPI-LY6G6D [extracellular region] (R-HSA-8943397) GPI-LY6G6D [plasma membrane] (R-HSA-8940814)	0.499	2
UniProt:Q9UBS3 DNAJB9	1	DNAJB9 [endoplasmic reticulum membrane] (R-HSA-381010)	0.499	2
UniProt:Q9NYU1 UGGT2	1	UGGT2 [endoplasmic reticulum lumen] (R-HSA-548863)	0.499	2
UniProt:P01721 IGLV6-57	2	Ig lambda chain V-VI region AR [plasma membrane] (R-HSA-2038816) Ig lambda chain V-VI region AR [extracellular region] (R-HSA-983569)	0.499	3
UniProt:Q6URK8 SMIP8			0.499	2
UniProt:P02452 COL1A1	20	3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441)	0.499	2
UniProt:P36780 VE2			0.488	2
UniProt:Q5NES6 Q5NES6			0.488	2
UniProt:Q2MV58 TCTN1	1	TCTN1 [cytosol] (R-HSA-5626659)	0.483	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.471	2
UniProt:Q8N0X7 SPART			0.462	2
UniProt:Q00005 2ABB			0.462	2

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