Reactome | HSPA5 [extracellular region]

HSPA5 [extracellular region]

Stable Identifier

R-HSA-351322

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

78 kDa glucose-regulated protein

Icon

Locations in the PathwayBrowser for interactor UniProt:Q9UBS4 DNAJB11

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External Reference Information

External Reference

UniProt:P11021 HSPA5

Gene Names

HSPA5, GRP78

Chain

signal peptide:1-18, chain:19-654

Reference Genes

BioGPS Gene:3309 HSPA5

COSMIC (genes):HSPA5 HSPA5

CTD Gene:3309 HSPA5

dbSNP Gene:3309 HSPA5

ENSEMBL:ENSG00000044574 HSPA5

ENSEMBL_homo_sapiens_GENE:ENSG00000044574.9 HSPA5

HGNC:5238 HSPA5

KEGG Gene (Homo sapiens):3309 HSPA5

Monarch:3309 HSPA5

NCBI Gene:3309 HSPA5

OMIM:138120 HSPA5

Reference Transcript

RefSeq:NM_005347.4 HSPA5

Other Identifiers

11725930_s_at

11725931_at

11725932_a_at

11725933_at

11725934_x_at

11758169_s_at

17098411

211936_PM_at

211936_at

230031_PM_at

230031_at

2331066

2331070

2331074

2331076

2331077

2750337

2750344

2750345

2750346

3225399

3225400

3225401

3225402

3225403

3225404

3225406

3225407

3225408

3225410

3225411

3225413

3225416

3225417

3225418

3225419

3225420

3309

36614_at

47634_at

8164165

A_24_P18190

A_24_P98411

GE86936

GO:0000166

GO:0003824

GO:0005509

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005739

GO:0005783

GO:0005788

GO:0005789

GO:0005793

GO:0005829

GO:0005886

GO:0005925

GO:0006351

GO:0006355

GO:0006457

GO:0006886

GO:0006983

GO:0008180

GO:0009986

GO:0012501

GO:0016020

GO:0016787

GO:0016887

GO:0019899

GO:0019904

GO:0021589

GO:0021680

GO:0021762

GO:0023052

GO:0030163

GO:0030335

GO:0030433

GO:0030496

GO:0030512

GO:0030968

GO:0031072

GO:0031204

GO:0031333

GO:0031398

GO:0031410

GO:0031625

GO:0032991

GO:0034663

GO:0034975

GO:0034976

GO:0035437

GO:0036211

GO:0036503

GO:0042026

GO:0042149

GO:0042470

GO:0043022

GO:0043066

GO:0043226

GO:0043231

GO:0044183

GO:0045296

GO:0045944

GO:0048856

GO:0048870

GO:0051082

GO:0051085

GO:0051087

GO:0051603

GO:0051787

GO:0055085

GO:0060904

GO:0065003

GO:0070062

GO:0071353

GO:0140657

GO:0140662

GO:1903891

GO:1903894

GO:1903895

GO:1903897

HMNXSV003037349

Hs.75410.1.S1_3p_at

Hs.75410.4.A1_3p_at

ILMN_1773865

M19645_at

PH_hs_0023711

TC09001589.hg

Participates

as an output of

Release of 78 kDa glucose-regulated protein (Homo sapiens)

Other forms of this molecule

HSPA5 [endoplasmic reticulum lumen]

HSPA5 [endoplasmic reticulum membrane]

HSPA5 [cytosol]

HSPA5 [nucleoplasm]

HSPA5 [lumenal side of endoplasmic reticulum membrane]

Cross References

RefSeq

NP_005338.1

Guide to Pharmacology - Targets

3193

OpenTargets

ENSG00000044574

ZINC - Substances

GRP78_HUMAN

ZINC target

P11021

ZINC - Biogenic

GRP78_HUMAN

PRO

P11021

PDB

5E86, 6DWS, 3LDP, 5E85, 6DFO, 6ASY, 3LDL, 3IUC, 7N1R, 5EVZ, 5F0X, 3LDN, 6DFM, 5E84, 5EX5, 6CZ1, 3LDO, 6DO2, 5EXW, 5EY4, 5F2R, 6ZMD, 5F1X

ZINC - Metabolites

GRP78_HUMAN

IntEnz

3.6.4.10

GeneCards

P11021

HPA

ENSG00000044574-HSPA5

Ensembl

ENSG00000044574, ENST00000324460, ENSP00000324173

Pharos - Targets

P11021

ZINC - Predictions - Purchasable

GRP78_HUMAN

Interactors (106)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UBS4 DNAJB11	1	DNAJB11 [endoplasmic reticulum lumen] (R-HSA-381040)	0.829	5
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.774	25
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9697006) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) fully glycosylated Spike [virion membrane] (R-COV-9698327) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791)	0.746	8
UniProt:Q9H173 SIL1			0.744	10
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.742	5
UniProt:Q9BYF1 ACE2	5	ACE2(18-805) [plasma membrane] (R-HSA-2022344) ACE2 [endoplasmic reticulum lumen] (R-HSA-9683474) glycosylated-ACE2 [endocytic vesicle membrane] (R-HSA-9686721) ACE2 [endocytic vesicle membrane] (R-HSA-9698958) glycosylated-ACE2 [plasma membrane] (R-HSA-9683480)	0.722	6
ChEBI:132781 HA15			0.687	8
UniProt:Q9Y4L1 HYOU1	3	HYOU1 [extracellular region] (R-HSA-3221939) HYOU1 [endocytic vesicle lumen] (R-HSA-3221924) HYOU1 [endoplasmic reticulum lumen] (R-HSA-535542)	0.669	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.666	6
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.659	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.659	4
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.643	7
UniProt:O94905 ERLIN2	3	ERLIN2 [endoplasmic reticulum membrane] (R-HSA-8866520) EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-p-8Y-FGFR1(1-822) [plasma membrane] (R-HSA-8853122) EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-FGFR1(1-822) [plasma membrane] (R-HSA-8853148)	0.643	3
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.638	4
UniProt:Q92874 DNSL2			0.623	3
UniProt:P36955 PEDF			0.623	3
UniProt:O75460-1 ERN1			0.612	4
UniProt:Q6E0U4 DMKN	1	DMKN [secretory granule lumen] (R-HSA-9839542)	0.602	3
UniProt:Q9NZJ5 EIF2AK3	3	EIF2AK3 [endoplasmic reticulum membrane] (R-HSA-381046) EIF2AK3(30-144)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713456) EIF2AK3(30-144)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713454)	0.589	4
UniProt:Q96IZ0 PAWR			0.581	8
UniProt:Q62627 PAWR			0.576	4
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.576	5
UniProt:P29322 EPHA8	2	EPHA8 [plasma membrane] (R-HSA-2682321) p-Y610,Y616-EPHA8 [plasma membrane] (R-HSA-3928350)	0.569	3
UniProt:Q9Y328 NSG2			0.564	2
UniProt:P49184 DNASE1L1	2	DNASE1L1 [extracellular region] (R-HSA-6806320) DNASE1L1 [specific granule lumen] (R-HSA-6799554)	0.564	3
UniProt:Q15084 PDIA6	3	PDIA6 [endoplasmic reticulum membrane] (R-HSA-535530) p-PDIA6 [endoplasmic reticulum lumen] (R-HSA-8957031) PDIA6 [endoplasmic reticulum lumen] (R-HSA-3009049)	0.564	2
UniProt:P09544 WNT2	9	WNT2 [extracellular region] (R-HSA-201690) N4GlycoAsn-PalmS WNT2 [extracellular exosome] (R-HSA-3781947) N4GlycoAsn-PalmS WNT2 [endocytic vesicle membrane] (R-HSA-3781972) WNT2 [endoplasmic reticulum lumen] (R-HSA-3238284) N4GlycoAsn-WNT2 [endoplasmic reticulum lumen] (R-HSA-3238226) N4GlycoAsn-PalmS WNT2 [endoplasmic reticulum lumen] (R-HSA-3238340) N4GlycoAsn-PalmS WNT2 [Golgi lumen] (R-HSA-3247819) N4GlycoAsn-PalmS WNT2 [extracellular region] (R-HSA-3247825) N4GlycoAsn-PalmS WNT2 [plasma membrane] (R-HSA-3247827)	0.564	2
UniProt:P14625 HSP90B1	4	HSP90B1 [endocytic vesicle lumen] (R-HSA-3221623) HSP90B1 [extracellular region] (R-HSA-3221653) p-HSP90B1 [endoplasmic reticulum lumen] (R-HSA-8957016) HSP90B1 [endoplasmic reticulum lumen] (R-HSA-981545)	0.564	2
UniProt:P61619 SEC61A1	2	SEC61A1 [endoplasmic reticulum membrane] (R-HSA-444591) SEC61A1 [phagocytic vesicle membrane] (R-HSA-1236813)	0.558	3
UniProt:Q9UHI5 SLC7A8	1	SLC7A8 [plasma membrane] (R-HSA-352156)	0.556	3
UniProt:Q13404 UBE2V1	1	UBE2V1 [cytosol] (R-HSA-205753)	0.556	3
UniProt:Q9ULD4-2 Q9ULD42			0.556	3
UniProt:Q6PF05 TT23L			0.556	3
UniProt:Q15486 GUSP1			0.556	3
UniProt:Q91YW3	5	Dnajc3 [extracellular region] (R-MMU-6806239) Dnajc3 [azurophil granule lumen] (R-MMU-6799146) Dnajc3 [cytosol] (R-MMU-448199) phospho-Dnajc3 [endoplasmic reticulum lumen] (R-MMU-8956975) Dnajc3 [endoplasmic reticulum lumen] (R-MMU-448201)	0.544	2
UniProt:P58166 INHBE	1	INHBE [extracellular region] (R-HSA-1449700)	0.527	2
UniProt:Q9BTY2 FUCA2	4	FUCA2 [extracellular region] (R-HSA-6806227) FUCA2 [azurophil granule lumen] (R-HSA-6798772) p-FUCA2 [endoplasmic reticulum lumen] (R-HSA-8957005) FUCA2 [endoplasmic reticulum lumen] (R-HSA-8956727)	0.527	2
UniProt:P13497 BMP1	1	BMP1 [extracellular region] (R-HSA-2002393)	0.527	2
UniProt:P05111 INHA	1	INHA [extracellular region] (R-HSA-1449702)	0.527	2
UniProt:O60513 B4GALT4	1	B4GALT4 [Golgi membrane] (R-HSA-975911)	0.527	2
UniProt:Q77M19 Q77M19			0.527	2
UniProt:P0DPA2 VSIG8			0.527	2
UniProt:Q6XE38 SG1D4			0.527	2
UniProt:Q96DN2 VWCE			0.527	2
UniProt:Q86YC3 LRC33			0.527	2
UniProt:Q8NG41 NPB	2	NPB(25-48) [extracellular region] (R-HSA-374794) NPB(25-53) [extracellular region] (R-HSA-374790)	0.527	2
UniProt:O95968 SG1D1			0.527	3
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.527	2
UniProt:Q8IV13 CCNJL			0.527	4
UniProt:P07307 ASGR2	1	PALM-C54,58-ASGR2 [plasma membrane] (R-HSA-8855706)	0.527	2
UniProt:Q92598 HSPH1	3	HSPH1 [cytosol] (R-HSA-3299412) HSPH1 [endocytic vesicle lumen] (R-HSA-3221904) HSPH1 [extracellular region] (R-HSA-3221883)	0.527	2
UniProt:Q96S86 HPLN3			0.527	2
UniProt:P49286 MTNR1B	1	MTNR1B [plasma membrane] (R-HSA-419349)	0.527	2
UniProt:O96009 NAPSA	1	NAPSA [multivesicular body lumen] (R-HSA-5684975)	0.527	2
UniProt:Q9UKU9 ANGL2			0.527	2
UniProt:Q14392 LRC32			0.527	2
UniProt:Q17R55 F187B			0.527	2
UniProt:Q9H6X2 ANTXR1			0.527	3
UniProt:Q7Z4N8 P4HA3	1	P4HA3 [endoplasmic reticulum lumen] (R-HSA-2980915)	0.527	2
UniProt:Q99592 ZBT18			0.527	2
UniProt:Q8IW92 GLB1L2	1	GLB1L2 [lysosomal lumen] (R-HSA-9840308)	0.527	2
UniProt:P48039 MTNR1A	1	MTNR1A [plasma membrane] (R-HSA-419316)	0.527	2
UniProt:Q6NSJ0 MYORG			0.527	2
UniProt:Q16842 ST3GAL2	1	ST3GAL2 [Golgi membrane] (R-HSA-981482)	0.527	2
UniProt:A5D8T8 CL18A			0.527	2
UniProt:Q96PQ1 SIGLEC12	1	SIGLEC12 [plasma membrane] (R-HSA-197729)	0.527	2
UniProt:P48052 CBPA2			0.527	2
UniProt:Q8WWA0 ITLN1	1	ITLN1 [extracellular region] (R-HSA-6804515)	0.527	4
UniProt:Q8TE60 ADAMTS18	4	ADAMTS18 [extracellular region] (R-HSA-3791290) ADAMTS18 [endoplasmic reticulum lumen] (R-HSA-5173116) glc-fuc-ADAMTS18 [endoplasmic reticulum lumen] (R-HSA-5173291) O-fuc-ADAMTS18 [endoplasmic reticulum lumen] (R-HSA-5173143)	0.527	2
UniProt:Q6UXI7 VITRN			0.527	2
UniProt:O00755 WNT7A	9	WNT7A [extracellular region] (R-HSA-517404) N4GlycoAsn-PalmS WNT7A [extracellular exosome] (R-HSA-3781951) N4GlycoAsn-PalmS WNT7A [endocytic vesicle membrane] (R-HSA-3781961) WNT7A [endoplasmic reticulum lumen] (R-HSA-3238312) N4GlycoAsn-WNT7A [endoplasmic reticulum lumen] (R-HSA-3238249) N4GlycoAsn-PalmS WNT7A [endoplasmic reticulum lumen] (R-HSA-3238354) N4GlycoAsn-PalmS WNT7A [Golgi lumen] (R-HSA-3247778) N4GlycoAsn-PalmS WNT7A [extracellular region] (R-HSA-3247774) N4GlycoAsn-PalmS WNT7A [plasma membrane] (R-HSA-3247833)	0.527	2
UniProt:Q8IXA5 SACA3			0.527	2
UniProt:Q5FYB1 ARSI	2	OxA-ARSI [endoplasmic reticulum lumen] (R-HSA-1614360) ARSI [endoplasmic reticulum lumen] (R-HSA-1609671)	0.527	2
UniProt:Q9Y581 INSL6			0.527	2
UniProt:Q9UI38 TSP50			0.527	3
UniProt:O95757 HSPA4L	2	HSPA4L [cytosol] (R-HSA-5251943) HSPA4L [nucleoplasm] (R-HSA-5252053)	0.527	2
UniProt:P07478 PRSS2	2	PRSS2 [azurophil granule lumen] (R-HSA-6799229) PRSS2(24-247) [extracellular region] (R-HSA-1460243)	0.527	2
UniProt:Q9H4B8 DPEP3			0.527	2
UniProt:Q8WXQ8 CBPA5			0.527	2
UniProt:P25685 DNAJB1	3	p-S149,S151,S171 DNAJB1 [cytosol] (R-HSA-5690241) DNAJB1 [cytosol] (R-HSA-3299666) DNAJB1 [nucleoplasm] (R-HSA-5082366)	0.527	2
UniProt:P01222 TSHB	1	TSHB [extracellular region] (R-HSA-378957)	0.527	2
UniProt:P01019 AGT	7	AGT(36-41) [extracellular region] (R-HSA-2022355) AGT(35-41) [extracellular region] (R-HSA-2022354) AGT(34-40) [extracellular region] (R-HSA-2022351) AGT(34-42) [extracellular region] (R-HSA-2022348) AGT [extracellular region] (R-HSA-1998759) AGT(34-43) [extracellular region] (R-HSA-2022346) AGT(34-41) [extracellular region] (R-HSA-374187)	0.527	2
UniProt:Q9HD89 RETN	3	RETN [specific granule lumen] (R-HSA-6799355) RETN [extracellular region] (R-HSA-6806172) RETN [azurophil granule lumen] (R-HSA-6799357)	0.527	2
UniProt:O43323 DHH	10	DHH(33-?) [extracellular region] (R-HSA-5362781) N4glycoAsn-2xHC-DHH(23-396) [endoplasmic reticulum lumen] (R-HSA-5362388) CHOL-DHH(23-198) [endoplasmic reticulum lumen] (R-HSA-5358291) N4glycoAsn-DHH(199-396) [endoplasmic reticulum lumen] (R-HSA-5358287) 2xHC-DHH(23-396) [endoplasmic reticulum lumen] (R-HSA-5358275) ub-N4glycoAsn-DHH(199-396) [cytosol] (R-HSA-5362368) ub-N4glycoAsn-DHH(199-396) [endoplasmic reticulum lumen] (R-HSA-5362411) CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [endoplasmic reticulum lumen] (R-HSA-5362442) CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [plasma membrane] (R-HSA-5362420) CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [extracellular region] (R-HSA-445155)	0.527	2
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.527	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.527	5
UniProt:P56705 WNT4	9	WNT4 [extracellular region] (R-HSA-517385) N4GlycoAsn-PalmS WNT4 [extracellular exosome] (R-HSA-3781964) N4GlycoAsn-PalmS WNT4 [endocytic vesicle membrane] (R-HSA-3781978) WNT4 [endoplasmic reticulum lumen] (R-HSA-3238297) N4GlycoAsn-WNT4 [endoplasmic reticulum lumen] (R-HSA-3238235) N4GlycoAsn-PalmS WNT4 [endoplasmic reticulum lumen] (R-HSA-3238347) N4GlycoAsn-PalmS WNT4 [Golgi lumen] (R-HSA-3247779) N4GlycoAsn-PalmS WNT4 [extracellular region] (R-HSA-3247794) N4GlycoAsn-PalmS WNT4 [plasma membrane] (R-HSA-3247809)	0.527	3
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.527	2
UniProt:Q13043 STK4	4	STK4(1-487) [cytosol] (R-HSA-201627) p-T183-STK4(1-326) [cytosol] (R-HSA-2028682) p-T183-STK4(1-487) [cytosol] (R-HSA-2028258) STK4(327-487) [cytosol] (R-HSA-2028668)	0.527	3
UniProt:Q07954 LRP1	2	LRP1 [plasma membrane] (R-HSA-1454844) LRP1 [endocytic vesicle membrane] (R-HSA-2230981)	0.527	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.527	3
UniProt:Q6T424 Q6T424			0.525	3
UniProt:K0BRG7 K0BRG7			0.524	9
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.508	3
UniProt:O95868 LY6G6D	2	cleaved GPI-LY6G6D [extracellular region] (R-HSA-8943397) GPI-LY6G6D [plasma membrane] (R-HSA-8940814)	0.499	2
UniProt:Q9NYU1 UGGT2	1	UGGT2 [endoplasmic reticulum lumen] (R-HSA-548863)	0.499	2
UniProt:P01721 IGLV6-57	2	Ig lambda chain V-VI region AR [plasma membrane] (R-HSA-2038816) Ig lambda chain V-VI region AR [extracellular region] (R-HSA-983569)	0.499	3
UniProt:Q6URK8 SMIP8			0.499	2
UniProt:Q9UBS3 DNAJB9	1	DNAJB9 [endoplasmic reticulum membrane] (R-HSA-381010)	0.499	2
UniProt:P02452 COL1A1	20	3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441)	0.499	2
UniProt:P36780 VE2			0.488	2
UniProt:Q5NES6 Q5NES6			0.488	2
UniProt:Q2MV58 TCTN1	1	TCTN1 [cytosol] (R-HSA-5626659)	0.483	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.471	2
UniProt:Q8N0X7 SPART			0.462	2
UniProt:Q00005 2ABB			0.462	2

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