Reactome | HDAC10 [nucleoplasm]

HDAC10 [nucleoplasm]

Stable Identifier

R-HSA-351579

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

HDA10_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P54252 ATXN3

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External Reference Information

External Reference

UniProt:Q969S8 HDAC10

Gene Names

HDAC10

Chain

chain:1-669

Reference Genes

BioGPS Gene:83933 HDAC10

COSMIC (genes):HDAC10 HDAC10

CTD Gene:83933 HDAC10

dbSNP Gene:83933 HDAC10

ENSEMBL:ENSG00000100429 HDAC10

ENSEMBL_homo_sapiens_GENE:ENSG00000100429.18 HDAC10

HGNC:18128 HDAC10

KEGG Gene (Homo sapiens):83933 HDAC10

Monarch:83933 HDAC10

NCBI Gene:83933 HDAC10

OMIM:608544 HDAC10

UCSC:Q969S8 HDAC10

Reference Transcript

Other Identifiers

11724583_a_at

16936360

226672_PM_s_at

226672_s_at

3965696

3965698

3965699

3965700

3965701

3965702

3965703

3965704

3965708

3965710

3965712

3965714

3965715

3965716

3965718

3965720

3965723

3965725

3965726

3965729

3965731

3965733

3965734

3965735

3965738

3965739

3965741

3965742

3965743

3965744

3965745

51132_at

63649_at

8076937

83933

GE80761

GO:0000118

GO:0000122

GO:0003824

GO:0004407

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006281

GO:0006310

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006914

GO:0006974

GO:0008270

GO:0010558

GO:0016236

GO:0016575

GO:0016787

GO:0019213

GO:0019899

GO:0032425

GO:0033558

GO:0034983

GO:0035825

GO:0036211

GO:0042826

GO:0043226

GO:0043231

GO:0045892

GO:0046872

GO:0047609

GO:0047611

GO:0106047

GO:0106048

GO:0140096

Hs.26593.0.S1_3p_a_at

PH_hs_0002346

TC22001497.hg

Participates

as a member of

HDAC [nucleoplasm] (Homo sapiens)

Inferred To

HDAC6 [nucleoplasm] (Drosophila melanogaster)

hdaD [nucleoplasm] (Dictyostelium discoideum)

clr3 [nucleoplasm] (Schizosaccharomyces pombe)

HDAC10 [nucleoplasm] (Bos taurus)

HDAC10 [nucleoplasm] (Canis familiaris)

HDAC10 [nucleoplasm] (Danio rerio)

HDAC10 [nucleoplasm] (Dictyostelium discoideum)

HDAC10 [nucleoplasm] (Gallus gallus)

HDAC10 [nucleoplasm] (Plasmodium falciparum)

HDAC10 [nucleoplasm] (Sus scrofa)

HDA1 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of HDAC10 [nucleoplasm] (Dictyostelium discoideum)

Homologues of HDAC10 [nucleoplasm] (Plasmodium falciparum)

Hdac10 [nucleoplasm] (Mus musculus)

Hdac10 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001152758.1, NP_114408.3

ZINC - World Drugs

HDA10_HUMAN

Guide to Pharmacology - Targets

2614

OpenTargets

ENSG00000100429

ZINC - FDA approved

HDA10_HUMAN

ZINC - Substances

HDA10_HUMAN

ZINC target

Q969S8

ZINC - Biogenic

HDA10_HUMAN

PRO

Q969S8

ZINC - Investigational

HDA10_HUMAN

GeneCards

Q969S8

HPA

ENSG00000100429-HDAC10

Ensembl

ENSG00000100429, ENST00000349505, ENSP00000406150, ENST00000216271, ENSP00000216271, ENST00000454936, ENSP00000343540

Pharos - Targets

Q969S8

ZINC - Predictions - Purchasable

HDA10_HUMAN

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	21
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:Q92870-2 Q928702			0.556	3
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:A0A6Q8PF08 A0A6Q8PF08			0.556	3
UniProt:Q96CV9 OPTN	6	OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [cytosol] (R-HSA-9687907) p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840)	0.556	3
UniProt:Q7Z412 PEX26	2	PEX26 [cytosol] (R-HSA-9603779) PEX26 [peroxisomal membrane] (R-HSA-9033092)	0.556	3
UniProt:Q9BYV2 TRI54			0.508	2

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