Reactome | GPS2 [nucleoplasm]

GPS2 [nucleoplasm]

Stable Identifier

R-HSA-351642

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

GPS2_HUMAN, G protein pathway suppressor 2, AMF1

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Locations in the PathwayBrowser for interactor UniProt:A5D8V6 VPS37C

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External Reference Information

External Reference

UniProt:Q13227 GPS2

Gene Names

GPS2

Chain

chain:1-327

Reference Genes

BioGPS Gene:2874 GPS2

COSMIC (genes):GPS2 GPS2

CTD Gene:2874 GPS2

dbSNP Gene:2874 GPS2

ENSEMBL:ENSG00000132522 GPS2

HGNC:4550 GPS2

KEGG:hsa:2874 GPS2

Monarch:2874 GPS2

NCBI Gene:2874 GPS2

OMIM:601935 GPS2

UCSC:Q13227 GPS2

Reference Transcript

RefSeq:NM_004489.4 GPS2

Other Identifiers

11747851_a_at

16840620

209350_3p_s_at

209350_PM_s_at

209350_s_at

213757_3p_at

213757_PM_at

213757_at

2874

3196764

3196765

3196771

3254421

35653_at

3743608

3743610

3743612

3743613

3743614

3743615

3743616

3743617

3743618

3743619

3743620

3743621

3743622

3743623

3743624

3743625

3743626

3743627

3743628

3743630

3743631

3743632

3743633

3743634

3743635

3743636

3743637

3743638

3743639

3743640

54872_at

8012150

A_23_P218405

A_33_P3608172

GE56839

GE85823

GO:0000122

GO:0002376

GO:0003712

GO:0003713

GO:0003714

GO:0005095

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005737

GO:0005739

GO:0005829

GO:0006355

GO:0006357

GO:0007254

GO:0010804

GO:0010875

GO:0017053

GO:0019216

GO:0030154

GO:0030183

GO:0030332

GO:0034122

GO:0035360

GO:0043226

GO:0045598

GO:0045599

GO:0045944

GO:0046329

GO:0050728

GO:0050859

GO:0060090

GO:0098772

GO:0098780

GO:0140110

GO:1900045

HMNXSV003008563

HMNXSV003011212

Hs.119140.1.A1_3p_at

Hs.119140.1.A1_3p_x_at

Hs.7301.2.S1_3p_a_at

ILMN_1815158

U28963_at

g7018539_3p_s_at

Participates

as a component of

as an input of

Oxysterol-induced binding of NR1H2,3:RXR to the ABCG1 gene (Homo sapiens)

Inferred To

gps2 [nucleoplasm] (Xenopus tropicalis)

Gps2 [nucleoplasm] (Mus musculus)

Gps2 [nucleoplasm] (Rattus norvegicus)

Dmel\CG17002 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of GPS2 [nucleoplasm] (Gallus gallus)

Ghost homologue of GPS2 [nucleoplasm] (Saccharomyces cerevisiae)

GPS2 [nucleoplasm] (Bos taurus)

GPS2 [nucleoplasm] (Canis familiaris)

GPS2 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_004480.1

OpenTargets

ENSG00000132522

ENSEMBL

ENSP00000379841, ENSP00000500677, ENST00000672046, ENST00000380728, ENST00000673265, ENSP00000370104, ENST00000389167, ENSP00000500255

HPA

ENSG00000132522-GPS2

PRO

Q13227

Pharos - Targets

Q13227

GlyGen

Q13227

PDB

2L5G

Interactors (62)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15311 RALBP1	1	RALBP1 [cytosol] (R-HSA-195194)	0.871	14
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.864	9
UniProt:P18848 ATF4	2	ATF4 [cytosol] (R-HSA-381084) ATF4 [nucleoplasm] (R-HSA-381016)	0.83	13
UniProt:Q86VW0 SESD1			0.781	7
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.735	7
UniProt:P06463 VE6			0.729	6
UniProt:P06462 VE6			0.729	6
UniProt:Q9Y618 NCOR2	2	NCOR2 [nucleoplasm] (R-HSA-442469) monoSUMO1-K672-NCOR2 [nucleoplasm] (R-HSA-3927904)	0.724	6
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.718	6
UniProt:O60907-2 TBL1X			0.656	6
UniProt:Q9BZK7 TBL1XR1	1	TBL1XR1 [nucleoplasm] (R-HSA-351643)	0.643	4
UniProt:P85037 FOXK1	1	FOXK1 [nucleoplasm] (R-HSA-5689673)	0.643	3
UniProt:P03122 VE2			0.593	5
UniProt:Q9Y2D1 ATF5	3	ATF5 [mitochondrial matrix] (R-HSA-9841250) ATF5 [cytosol] (R-HSA-9841253) ATF5 [nucleoplasm] (R-HSA-9653719)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:Q16633 OBF1			0.556	3
UniProt:Q53HV7-2 SMUG1			0.556	3
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.556	5
UniProt:A1KXE4-2 FAM168B			0.556	3
UniProt:A5D8V6 VPS37C	1	VPS37C [endosome membrane] (R-HSA-184438)	0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:Q8WUN7 UBTD2			0.556	3
UniProt:Q15654 TRIP6			0.556	3
UniProt:Q5BKX5-3 ACTMAP			0.556	3
UniProt:P31943 HNRNPH1	1	HNRNPH1 [nucleoplasm] (R-HSA-71941)	0.556	3
UniProt:Q9UHB4 NDOR1	1	NDOR1 [cytosol] (R-HSA-2564776)	0.556	5
UniProt:Q8IUC1 KRTAP11-1	1	KRTAP11-1 [cytosol] (R-HSA-6810294)	0.556	3
UniProt:Q52LG2 KRTAP13-2	1	KRTAP13-2 [cytosol] (R-HSA-6810274)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q5TD97 FHL5			0.556	3
UniProt:Q93062 RBPMS			0.556	3
IntAct:EBI-22412087 CCSB ORF ID			0.556	3
UniProt:Q7Z3Y8 KRT27	1	KRT27 [cytosol] (R-HSA-6809587)	0.556	3
UniProt:Q9ULX6 AKAP8L	1	AKAP8L [nucleoplasm] (R-HSA-9821364)	0.556	3
UniProt:Q9BYR8 KRTAP3-1	1	KRTAP3-1 [cytosol] (R-HSA-6809868)	0.556	3
UniProt:Q05BL1 Q05BL1			0.556	3
UniProt:Q15038 DAZP2			0.556	3
UniProt:Q5TA45 CPSF3L	1	CPSF3L [nucleoplasm] (R-HSA-6807411)	0.556	3
UniProt:Q9BYR6 KRTAP3-3	1	KRTAP3-3 [cytosol] (R-HSA-6809859)	0.556	3
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.556	3
UniProt:O76013-2 KRT36			0.556	3
UniProt:Q3LI64 KRTAP6-1	1	KRTAP6-1 [cytosol] (R-HSA-6810298)	0.556	3
UniProt:Q3LI67 KRTAP6-3	1	KRTAP6-3 [cytosol] (R-HSA-6810281)	0.556	3
UniProt:Q3LI66 KRTAP6-2	1	KRTAP6-2 [cytosol] (R-HSA-6810261)	0.556	5
UniProt:O75376 NCOR1	2	NCOR1 [cytosol] (R-HSA-1253310) NCOR1 [nucleoplasm] (R-HSA-442501)	0.527	3
UniProt:P03126 VE6			0.527	3
UniProt:O43293 DAPK3	1	DAPK3 [cytosol] (R-HSA-418265)	0.527	3
UniProt:Q01167 FOXK2	1	FOXK2 [nucleoplasm] (R-HSA-5689655)	0.527	2
UniProt:Q6AZZ1 TRIM68	1	TRIM68 [cytosol] (R-HSA-5624350)	0.527	2
UniProt:P06929 VE6			0.527	2
UniProt:Q6UB99 ANR11			0.527	3
UniProt:O00399 DCTN6	1	DCTN6 [cytosol] (R-HSA-2029035)	0.527	2
UniProt:P27361 MAPK3	6	p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) MAPK3 [cytosol] (R-HSA-59284) MAPK3 [nucleoplasm] (R-HSA-73724) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295)	0.527	2
UniProt:Q9BQ87 TBL1Y			0.527	4
UniProt:Q8IVV7 GID4	1	GID4 [cytosol] (R-HSA-9861538)	0.527	2
UniProt:Q9NZ32 ACTR10	4	ACTR10 [cytosol] (R-HSA-6801556) ACTR10 [ficolin-1-rich granule lumen] (R-HSA-6801072) ACTR10 [extracellular region] (R-HSA-6806245) ACTR10 [azurophil granule lumen] (R-HSA-6801080)	0.527	2
UniProt:P06428 VE6			0.527	2
UniProt:Q9WMX2-PRO_0000037551			0.508	2
UniProt:P57077 M3KCL			0.508	2
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.499	2
UniProt:P12504 VIF			0.499	2
UniProt:P06921 VE2			0.488	2

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