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SLC6A12 [plasma membrane]
Stable Identifier
R-HSA-351969
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
BGT-1, Sodium- and chloride-dependent betaine transporter
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Creatine metabolism (Homo sapiens)
Creatine transport across the plasma membrane (Homo sapiens)
SLC6A8-like proteins [plasma membrane] (Homo sapiens)
SLC6A12 [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
GABA synthesis, release, reuptake and degradation (Homo sapiens)
Reuptake of GABA (Homo sapiens)
SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Homo sapiens)
SLC6A12 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Na+/Cl- dependent neurotransmitter transporters (Homo sapiens)
SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Homo sapiens)
SLC6A12 [plasma membrane] (Homo sapiens)
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Amino acid transport across the plasma membrane (Homo sapiens)
SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Homo sapiens)
SLC6A12 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P48065 SLC6A12
Gene Names
SLC6A12, BGT1
Chain
chain:1-614
Reference Genes
BioGPS Gene:6539 SLC6A12
COSMIC (genes):SLC6A12 SLC6A12
CTD Gene:6539 SLC6A12
dbSNP Gene:6539 SLC6A12
ENSEMBL:ENSG00000111181 SLC6A12
ENSEMBL_homo_sapiens_GENE:ENSG00000111181.13 SLC6A12
HGNC:11045 SLC6A12
KEGG Gene (Homo sapiens):6539 SLC6A12
Monarch:6539 SLC6A12
NCBI Gene:6539 SLC6A12
OMIM:603080 SLC6A12
UCSC:P48065 SLC6A12
Reference Transcript
RefSeq:NM_001122847.2 SLC6A12
RefSeq:NM_003044.4 SLC6A12
RefSeq:XM_011521010.1 SLC6A12
RefSeq:NM_001122848.2 SLC6A12
RefSeq:NM_001206931.1 SLC6A12
Other Identifiers
11731647_a_at
11740494_a_at
11740495_x_at
16759751
206058_PM_at
206058_at
3439508
3439509
3439511
3439512
3439516
3439518
3439519
3439520
3439521
3439523
3439524
3439525
3439527
3439528
3439529
3439531
3439533
3439534
3439536
3439537
3439538
3439539
3439540
3439541
3439542
40679_at
6539
7960177
A_23_P76386
GE59044
GO:0003333
GO:0005215
GO:0005332
GO:0005515
GO:0005886
GO:0006836
GO:0006865
GO:0008028
GO:0015171
GO:0015293
GO:0015718
GO:0015812
GO:0016020
GO:0016323
GO:0022857
GO:0031460
GO:0035725
GO:0051936
GO:0055085
GO:0071702
GO:0071705
GO:0098793
HMNXSV003048169
TC12001079.hg
U27699_at
g881474_3p_at
Participates
as a candidate of
SLC6A8-like proteins [plasma membrane] (Homo sapiens)
Inferred To
si:ch211-132b12.1 [plasma membrane]
(Danio rerio)
Homologues of SLC6A12 [plasma membrane]
(Danio rerio)
Homologues of SLC6A12 [plasma membrane]
(Plasmodium falciparum)
Slc6a12 [plasma membrane]
(Mus musculus)
Slc6a12 [plasma membrane]
(Rattus norvegicus)
SLC6A12 [plasma membrane]
(Bos taurus)
SLC6A12 [plasma membrane]
(Canis familiaris)
SLC6A12 [plasma membrane]
(Gallus gallus)
SLC6A12 [plasma membrane]
(Plasmodium falciparum)
SLC6A12 [plasma membrane]
(Sus scrofa)
slc6a12 [plasma membrane]
(Xenopus tropicalis)
slc6a11a [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_001116320.1
,
NP_001116319.1
,
NP_003035.3
,
NP_001193860.1
,
XP_011519312.1
Guide to Pharmacology - Targets
932
OpenTargets
ENSG00000111181
ZINC - Substances
S6A12_HUMAN
GeneCards
P48065
HPA
ENSG00000111181-SLC6A12
ZINC target
P48065
Ensembl
ENSP00000352702
,
ENST00000359674
,
ENSG00000111181
,
ENSP00000508194
,
ENSP00000444268
,
ENST00000397296
,
ENST00000684302
,
ENSP00000380464
,
ENSP00000399136
,
ENST00000536824
,
ENST00000424061
PRO
P48065
Pharos - Targets
P48065
ZINC - Predictions - Purchasable
S6A12_HUMAN
HMDB Protein
HMDBP02695
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.573
2
UniProt:P11912 CD79A
2
p-Y188,Y199-CD79A [plasma membrane]
(R-HSA-983539)
CD79A [plasma membrane]
(R-HSA-197154)
0.556
3
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.556
3
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