SLC43A2 (LAT4)-mediated uptake of large neutral amino acids

Stable Identifier
R-HSA-352107
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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SLC43A2 (LAT4)-mediated uptake of large neutral amino acids
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SLC43A2 (LAT4), associated with the plasma membrane, mediates the uptake of isoleucine, leucine, methionine, phenylalanine, and valine in a biphasic and sodium ion-independent transport process. Northern blotting and in situ hybridization experiments indicate gene expression in kidney and intestine (Bodoy et al. 2005).
Literature References
PubMed ID Title Journal Year
15659399 Identification of LAT4, a novel amino acid transporter with system L activity

Bodoy, S, Palacin, M, Zorzano, A, Bertran, J, Estévez, R, Martin, L

J Biol Chem 2005
Participants
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Output
Participates
as an event of
Catalyst Activity

amino acid transmembrane transporter activity of SLC43A2 [plasma membrane]

Physical Entity
SLC43A2 [plasma membrane] (Homo sapiens)
Activity
amino acid transmembrane transporter activity (GO:0015171)
Orthologous Events
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Bos taurus)
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Canis familiaris)
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Gallus gallus)
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Mus musculus)
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Rattus norvegicus)
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Sus scrofa)
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2008-06-03)
Reviewed
Jassal, B  (2008-06-03)
Created
D'Eustachio, P  (2008-05-30)
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