Reactome | SLC43A2 (LAT4)-mediated uptake of large neutral amino acids

SLC43A2 (LAT4)-mediated uptake of large neutral amino acids

Stable Identifier

R-HSA-352107

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SLC43A2 (LAT4)-mediated uptake of large neutral amino acids

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SLC43A2 (LAT4), associated with the plasma membrane, mediates the uptake of isoleucine, leucine, methionine, phenylalanine, and valine in a biphasic and sodium ion-independent transport process. Northern blotting and in situ hybridization experiments indicate gene expression in kidney and intestine (Bodoy et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15659399	Identification of LAT4, a novel amino acid transporter with system L activity Bodoy, S, Martin, L, Zorzano, A, Palacin, M, Estévez, R, Bertran, J	J Biol Chem	2005