Reactome | SLC16A10-mediated uptake of aromatic amino acids

SLC16A10-mediated uptake of aromatic amino acids

Stable Identifier

R-HSA-352158

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SLC16A10-mediated uptake of aromatic amino acids

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SLC16A10 mediates the reversible facilitated diffusion of phenylalanine, tyrosine, and tryptophan across the plasma membrane. The process is Na+-independent and not coupled to H+ transport. As measured by Northern blotting SLC16A10 is widely expressed in the body but especially abundant in kidney. In situ hybridization studies indicate that the gene product is abundant in kidney proximal tubules (Kim et al. 2001; Kim et al. 2002; Park et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
11827462	The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location Cha, SH, Chairoungdua, A, Endou, H, Kim, DK, Kobayashi, Y, Matsuo, H, Goya, T, Kanai, Y, Kim, JY, Enomoto, A	Genomics	2002
15918515	Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule Park, KJ, Chairoungdua, A, Endou, H, Kim, JK, Kim, DK, Kim, IJ, Lee, S, Park, SY, Kanai, Y, Jung, KY, Choi, BK	Arch Pharm Res	2005
11278508	Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters Cha, SH, Chairoungdua, A, Endou, H, Kim, DK, Matsuo, H, Kanai, Y	J Biol Chem	2001