Reactome | SLC3A2 [plasma membrane]

SLC3A2 [plasma membrane]

Stable Identifier

R-HSA-352179

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

4F2hc, 4F2 cell-surface antigen heavy chain

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P08195 SLC3A2

Gene Names

SLC3A2, MDU1

Chain

initiator methionine:, chain:1-630

Reference Genes

BioGPS Gene:6520 SLC3A2

COSMIC (genes):SLC3A2 SLC3A2

CTD Gene:6520 SLC3A2

dbSNP Gene:6520 SLC3A2

ENSEMBL:ENSG00000168003 SLC3A2

ENSEMBL_homo_sapiens_GENE:ENSG00000168003.19 SLC3A2

HGNC:11026 SLC3A2

KEGG Gene (Homo sapiens):6520 SLC3A2

Monarch:6520 SLC3A2

NCBI Gene:6520 SLC3A2

OMIM:158070 SLC3A2

UCSC:P08195 SLC3A2

Reference Transcript

Other Identifiers

11733071_a_at

11741149_x_at

11741582_a_at

11746697_a_at

11753434_a_at

11753435_x_at

11754529_x_at

16725984

200924_3p_s_at

200924_PM_s_at

200924_s_at

3333712

3333716

3333717

3333718

3333719

3333720

3333721

3333722

3333724

3333730

3333734

3333735

3333736

3333738

3333742

3333744

3333745

3333746

3333747

3333748

3333749

38029_at

6520

73232_s_at

73338_s_at

7940717

80495_s_at

A_14_P124364

A_23_P75811

A_23_P87216

GE472388

GE53434

GO:0001618

GO:0003723

GO:0003725

GO:0005215

GO:0005294

GO:0005432

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005764

GO:0005765

GO:0005773

GO:0005886

GO:0005975

GO:0006816

GO:0006865

GO:0009925

GO:0009986

GO:0015173

GO:0015175

GO:0015180

GO:0015190

GO:0015818

GO:0015820

GO:0015821

GO:0015823

GO:0015824

GO:0015827

GO:0015828

GO:0015829

GO:0016020

GO:0016323

GO:0016324

GO:0031410

GO:0035725

GO:0042470

GO:0042803

GO:0043025

GO:0043226

GO:0043330

GO:0044225

GO:0045202

GO:0045296

GO:0046718

GO:0046982

GO:0055085

GO:0070062

GO:0070161

GO:0070327

GO:0098713

GO:0140272

GO:1902024

GO:1903801

GO:1904273

GO:1990184

HMNXSV003042463

ILMN_1679041

ILMN_1726456

M21904_at

TC11000567.hg

TC11002708.hg

g4505140_3p_a_at

p33663

Participates

as a component of

Inferred To

SLC3A2 [plasma membrane] (Bos taurus)

SLC3A2 [plasma membrane] (Canis familiaris)

SLC3A2 [plasma membrane] (Danio rerio)

SLC3A2 [plasma membrane] (Sus scrofa)

CD98hc [plasma membrane] (Drosophila melanogaster)

Homologues of SLC3A2 [plasma membrane] (Danio rerio)

Slc3a2 [plasma membrane] (Mus musculus)

Slc3a2 [plasma membrane] (Rattus norvegicus)

slc3a2 [plasma membrane] (Xenopus tropicalis)

slc3a2b [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_001012682.1, NP_002385.3, NP_001012680.1, NP_001013269.1

Guide to Pharmacology - Targets

890

OpenTargets

ENSG00000168003

GeneCards

P08195

HPA

ENSG00000168003-SLC3A2

Ensembl

ENSP00000442135, ENSP00000340815, ENST00000538084, ENST00000377889, ENSP00000440001, ENST00000680631, ENSP00000367123, ENSP00000367121, ENST00000338663, ENST00000377891, ENSP00000367122, ENST00000377890, ENSP00000505110, ENST00000681657, ENSG00000168003, ENSP00000506006, ENST00000544377

PRO

P08195

Pharos - Targets

P08195

HMDB Protein

HMDBP03090

PDB

7DSK, 2DH2, 7CMI, 6JMQ, 7B00, 7CMH, 2DH3, 7EPZ, 6IRT, 7P9V, 8QEY, 7P9U, 8G0M, 6IRS, 7CCS, 7DF1, 7DSQ, 7DSN, 6S8V, 8A6L, 7DSL, 6JMR

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.643	5
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.597	3
UniProt:O15354 GPR37	1	GPR37 [plasma membrane] (R-HSA-5333623)	0.581	3
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.527	2

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