SLC7A8-mediated uptake of neutral amino acids

Stable Identifier
Reaction [transition]
Homo sapiens
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SLC7A8, complexed with SLC3A2 in the plasma membrane, mediates the uptake of neutral amino acids. The process is Na+-independent and not coupled to H+ transport. As measured by Northern blotting SLC7A8 is widely expressed in the body. In situ hybridization studies indicate that the gene product is abundant in kidney proximal tubules (Pineda et al. 1999; Park et al. 2005)
Literature References
PubMed ID Title Journal Year
10391915 Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids

Palacin, M, Torrents, D, Zorzano, A, Lloberas, J, López, C, Fernández, E, Pineda, M, Camps, M, Estévez, R

J Biol Chem 1999
15918515 Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule

Park, KJ, Chairoungdua, A, Endou, H, Kim, JK, Kim, DK, Kim, IJ, Lee, S, Park, SY, Kanai, Y, Jung, KY, Choi, BK

Arch Pharm Res 2005
Catalyst Activity

amino acid transmembrane transporter activity of SLC7A8:SLC3A2 heterodimer [plasma membrane]

Orthologous Events
Cross References
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