SLC7A8-mediated uptake of neutral amino acids

Stable Identifier
R-HSA-352191
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SLC7A8-mediated uptake of neutral amino acids
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SLC7A8, complexed with SLC3A2 in the plasma membrane, mediates the uptake of neutral amino acids. The process is Na+-independent and not coupled to H+ transport. As measured by Northern blotting SLC7A8 is widely expressed in the body. In situ hybridization studies indicate that the gene product is abundant in kidney proximal tubules (Pineda et al. 1999; Park et al. 2005)
Literature References
PubMed ID Title Journal Year
15918515 Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule

Park, SY, Kim, JK, Kim, IJ, Choi, BK, Jung, KY, Lee, S, Park, KJ, Chairoungdua, A, Kanai, Y, Endou, H, Kim, DK

Arch Pharm Res 2005
10391915 Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids

Pineda, M, Fernández, E, Torrents, D, Estévez, R, López, C, Camps, M, Lloberas, J, Zorzano, A, Palacin, M

J Biol Chem 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

amino acid transmembrane transporter activity of SLC7A8:SLC3A2 heterodimer [plasma membrane]

Physical Entity
SLC7A8:SLC3A2 heterodimer [plasma membrane] (Homo sapiens)
Activity
amino acid transmembrane transporter activity (GO:0015171)
Orthologous Events
SLC7A8-mediated uptake of neutral amino acids (Bos taurus)
SLC7A8-mediated uptake of neutral amino acids (Canis familiaris)
SLC7A8-mediated uptake of neutral amino acids (Danio rerio)
SLC7A8-mediated uptake of neutral amino acids (Drosophila melanogaster)
SLC7A8-mediated uptake of neutral amino acids (Mus musculus)
SLC7A8-mediated uptake of neutral amino acids (Rattus norvegicus)
SLC7A8-mediated uptake of neutral amino acids (Sus scrofa)
SLC7A8-mediated uptake of neutral amino acids (Xenopus tropicalis)
Cross References
RHEA
Authored
D'Eustachio, P  (2008-06-03)
Reviewed
Jassal, B  (2008-06-03)
Created
D'Eustachio, P  (2008-06-01)
Cite Us!